hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_01652.1

Complex Portal: CPX-11573

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
PRKAG1	5'-AMP-activated protein kinase subunit gamma-1 (AMPK gamma1) (AMPK subunit gamma-1) (AMPKg)	5	UniProt NCBI
PRKAB2	5'-AMP-activated protein kinase subunit beta-2 (AMPK subunit beta-2)	5	UniProt NCBI
PRKAG2	5'-AMP-activated protein kinase subunit gamma-2 (AMPK gamma2) (AMPK subunit gamma-2) (H91620p)	5	UniProt NCBI
PRKAA2	5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31)	5	UniProt NCBI
PRKAB1	5'-AMP-activated protein kinase subunit beta-1 (AMPK subunit beta-1) (AMPKb)	5	UniProt NCBI
PRKAA1	5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26)	5	UniProt NCBI
PRKAG3	5'-AMP-activated protein kinase subunit gamma-3 (AMPK gamma3) (AMPK subunit gamma-3)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP4905	5.47432140199e-19	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	1q21 1 copy number variation syndrome
WP:WP3965	2.11148361609e-18	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Lipid metabolism pathway
REAC:R-HSA-9619483	3.30131785414e-18	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Activation of AMPK downstream of NMDARs
KEGG:04710	3.76532549949e-18	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Circadian rhythm
WP:WP4923	3.80067050897e-18	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Autophagy
REAC:R-HSA-2151209	8.42629275631e-18	0.857142857143	PRKAG1 PRKAG3 PRKAA2 PRKAB1 PRKAG2 PRKAB2	Activation of PPARGC1A (PGC-1alpha) by phosphorylation
REAC:R-HSA-9613354	8.42629275631e-18	0.857142857143	PRKAG1 PRKAG3 PRKAA2 PRKAB1 PRKAG2 PRKAB2	Lipophagy
REAC:R-HSA-380972	1.07190157695e-17	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Energy dependent regulation of mTOR by LKB1-AMPK
GO:0031588	1.14020115269e-17	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	nucleotide-activated protein kinase complex
WP:WP1471	1.72681225979e-17	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Target of rapamycin signaling
WP:WP4539	1.2300585511e-16	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Synaptic signaling pathways associated with autism spectrum disorder
WP:WP1541	1.2300585511e-16	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Energy metabolism
REAC:R-HSA-165159	1.54399895814e-16	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	MTOR signalling
KEGG:04213	3.27557350693e-16	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Longevity regulating pathway - multiple species
KEGG:04920	1.02330492467e-15	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Adipocytokine signaling pathway
WP:WP1403	1.40039313492e-15	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	AMP activated protein kinase signaling
WP:WP1982	3.11183478263e-15	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Sterol regulatory element binding proteins SREBP signaling
KEGG:05410	4.04347907188e-15	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Hypertrophic cardiomyopathy
KEGG:04211	6.43130579194e-15	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Longevity regulating pathway
REAC:R-HSA-438064	6.65787906982e-15	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Post NMDA receptor activation events
WP:WP4963	1.11615778056e-14	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	p53 transcriptional gene network
WP:WP4540	1.22033250674e-14	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Hippo signaling regulation pathways
KEGG:04922	1.6203132772e-14	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Glucagon signaling pathway
REAC:R-HSA-5628897	1.99078581113e-14	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	TP53 Regulates Metabolic Genes
REAC:R-HSA-442755	2.18168308069e-14	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Activation of NMDA receptors and postsynaptic events
KEGG:04931	2.55875177383e-14	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Insulin resistance
WP:WP4321	2.59810393357e-14	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Thermogenesis
REAC:R-HSA-6804756	4.73205047984e-14	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Regulation of TP53 Activity through Phosphorylation
KEGG:04371	6.28176576488e-14	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Apelin signaling pathway
KEGG:04152	7.14303931e-14	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	AMPK signaling pathway
KEGG:04068	7.14303931e-14	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	FoxO signaling pathway
KEGG:04921	9.7512860186e-14	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Oxytocin signaling pathway
WP:WP3915	1.32078018611e-13	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Angiopoietin like protein 8 regulatory pathway
KEGG:04936	1.39225597792e-13	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Alcoholic liver disease
KEGG:04910	1.56160316567e-13	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Insulin signaling pathway
KEGG:04530	3.15558911241e-13	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Tight junction
KEGG:04932	3.15558911241e-13	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Non-alcoholic fatty liver disease
WP:WP4396	4.93694422163e-13	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Nonalcoholic fatty liver disease
REAC:R-HSA-1632852	5.79851097949e-13	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Macroautophagy
REAC:R-HSA-9612973	1.29782746648e-12	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Autophagy
REAC:R-HSA-5633007	2.22030507039e-12	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Regulation of TP53 Activity
REAC:R-HSA-112314	2.92719367156e-12	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Neurotransmitter receptors and postsynaptic signal transmission
KEGG:04714	5.03439681856e-12	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Thermogenesis
REAC:R-HSA-1445148	1.1982929499e-11	0.857142857143	PRKAG1 PRKAG3 PRKAA2 PRKAB1 PRKAG2 PRKAB2	Translocation of SLC2A4 (GLUT4) to the plasma membrane
REAC:R-HSA-112315	1.74357500814e-11	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Transmission across Chemical Synapses
REAC:R-HSA-9663891	2.0120750683e-11	0.857142857143	PRKAG1 PRKAG3 PRKAA2 PRKAB1 PRKAG2 PRKAB2	Selective autophagy
REAC:R-HSA-1592230	4.69495631931e-11	0.857142857143	PRKAG1 PRKAG3 PRKAA2 PRKAB1 PRKAG2 PRKAB2	Mitochondrial biogenesis
REAC:R-HSA-112316	2.64890830354e-10	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Neuronal System
GO:1902911	3.70329553914e-10	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	protein kinase complex
WP:WP5087	5.9320283559e-10	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Pleural mesothelioma
REAC:R-HSA-3700989	6.45122444413e-10	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Transcriptional Regulation by TP53
GO:0031669	8.63691025512e-10	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	cellular response to nutrient levels
GO:0004679	9.2094208532e-10	0.571428571429	PRKAB2 PRKAG3 PRKAA2 PRKAA1	AMP-activated protein kinase activity
GO:0031668	1.27291571214e-09	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	cellular response to extracellular stimulus
GO:0071496	4.65826598113e-09	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	cellular response to external stimulus
CORUM:6155	7.02338504734e-09	0.428571428571	PRKAG1 PRKAA2 PRKAB2	PRKAA2-PRKAB2-PRKAG1 complex
CORUM:6154	7.02338504734e-09	0.428571428571	PRKAG1 PRKAA1 PRKAB2	PRKAA1-PRKAB2-PRKAG1 complex
CORUM:6153	7.02338504734e-09	0.428571428571	PRKAB2 PRKAA2 PRKAG3	PRKAA2-PRKAB2-PRKAG3 complex
GO:0031667	7.70989242031e-09	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	response to nutrient levels
GO:0009991	1.09160467306e-08	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	response to extracellular stimulus
GO:0061695	3.97245817071e-08	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	transferase complex, transferring phosphorus-containing groups
REAC:R-HSA-1852241	5.61487392461e-08	0.857142857143	PRKAG1 PRKAG3 PRKAA2 PRKAB1 PRKAG2 PRKAB2	Organelle biogenesis and maintenance
REAC:R-HSA-163680	7.29464907751e-07	0.428571428571	PRKAB2 PRKAG2 PRKAA2	AMPK inhibits chREBP transcriptional activation activity
WP:WP3934	7.30297581269e-07	0.428571428571	PRKAG1 PRKAA1 PRKAB1	Leptin and adiponectin
REAC:R-HSA-212436	1.58683997122e-06	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Generic Transcription Pathway
CORUM:6888	2.55074322511e-06	0.428571428571	PRKAG1 PRKAA1 PRKAB1	v-ATPase-Ragulator-AXIN/LKB1-AMPK complex
REAC:R-HSA-73857	3.43065876654e-06	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	RNA Polymerase II Transcription
REAC:R-HSA-200425	3.72165755864e-06	0.428571428571	PRKAB2 PRKAG2 PRKAA2	Carnitine metabolism
REAC:R-HSA-199991	4.64440301142e-06	0.857142857143	PRKAG1 PRKAG3 PRKAA2 PRKAB1 PRKAG2 PRKAB2	Membrane Trafficking
REAC:R-HSA-5653656	6.43124786339e-06	0.857142857143	PRKAG1 PRKAG3 PRKAA2 PRKAB1 PRKAG2 PRKAB2	Vesicle-mediated transport
WP:WP4206	6.92358935837e-06	0.428571428571	PRKAG1 PRKAA1 PRKAB1	Hereditary leiomyomatosis and renal cell carcinoma pathway
REAC:R-HSA-74160	8.27787730998e-06	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Gene expression (Transcription)
GO:0006110	5.39634524328e-05	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	regulation of glycolytic process
GO:0030811	5.39634524328e-05	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	regulation of nucleotide catabolic process
GO:0033121	5.39634524328e-05	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	regulation of purine nucleotide catabolic process
GO:1990234	5.8503111345e-05	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	transferase complex
GO:0140535	8.76375670222e-05	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	intracellular protein-containing complex
GO:0043470	0.000102438985779	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	regulation of carbohydrate catabolic process
GO:1903578	0.000177904951493	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	regulation of ATP metabolic process
REAC:R-HSA-162582	0.000187648625697	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	Signal Transduction
GO:0004672	0.000245678642369	0.857142857143	PRKAG1 PRKAG3 PRKAA2 PRKAB1 PRKAB2 PRKAA1	protein kinase activity
GO:1900542	0.000415369664364	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	regulation of purine nucleotide metabolic process
GO:0006140	0.000444965621816	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	regulation of nucleotide metabolic process
GO:0016208	0.000554182028596	0.428571428571	PRKAG1 PRKAG2 PRKAG3	AMP binding
GO:0006096	0.000617288463902	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	glycolytic process
GO:0046032	0.000617288463902	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	ADP catabolic process
GO:0046031	0.000657005257405	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	ADP metabolic process
GO:0009181	0.000698604747216	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	purine ribonucleoside diphosphate catabolic process
GO:0009137	0.000698604747216	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	purine nucleoside diphosphate catabolic process
GO:0009179	0.000742145232605	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	purine ribonucleoside diphosphate metabolic process
GO:0019364	0.000742145232605	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	pyridine nucleotide catabolic process
GO:0009135	0.00078768588516	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	purine nucleoside diphosphate metabolic process
GO:0016773	0.000794204063265	0.857142857143	PRKAG1 PRKAG3 PRKAA2 PRKAB1 PRKAB2 PRKAA1	phosphotransferase activity, alcohol group as acceptor
GO:0009191	0.000835286748042	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	ribonucleoside diphosphate catabolic process
GO:0072526	0.000885008735247	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	pyridine-containing compound catabolic process
GO:0009134	0.000936913630871	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	nucleoside diphosphate catabolic process
GO:0009185	0.00116762839146	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	ribonucleoside diphosphate metabolic process
GO:0016301	0.00121084011862	0.857142857143	PRKAG1 PRKAG3 PRKAA2 PRKAB1 PRKAB2 PRKAA1	kinase activity
GO:0009132	0.00143843813729	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	nucleoside diphosphate metabolic process
REAC:R-HSA-163685	0.00155569177621	0.428571428571	PRKAB2 PRKAG2 PRKAA2	Integration of energy metabolism
GO:0006090	0.00211804437713	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	pyruvate metabolic process
GO:0009154	0.002536243155	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	purine ribonucleotide catabolic process
WP:WP5381	0.00265193272199	0.428571428571	PRKAB1 PRKAG2 PRKAA1	Smith Magenis and Potocki Lupski syndrome copy number variation
GO:0009261	0.0027671063547	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	ribonucleotide catabolic process
WP:WP1981	0.00303405736115	0.285714285714	PRKAA2 PRKAA1	Thyroxine thyroid hormone production
GO:0043467	0.00314242734718	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	regulation of generation of precursor metabolites and energy
GO:0006195	0.00327560699829	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	purine nucleotide catabolic process
GO:0016772	0.00380461313894	0.857142857143	PRKAG1 PRKAG3 PRKAA2 PRKAB1 PRKAB2 PRKAA1	transferase activity, transferring phosphorus-containing groups
GO:0072523	0.00385096114287	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	purine-containing compound catabolic process
GO:0016052	0.0041654421892	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	carbohydrate catabolic process
GO:0006109	0.00541917186662	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	regulation of carbohydrate metabolic process
GO:0009605	0.00565166508627	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	response to external stimulus
GO:0004674	0.0058499573846	0.714285714286	PRKAG1 PRKAA1 PRKAG3 PRKAA2 PRKAB2	protein serine/threonine kinase activity
GO:0009166	0.00625142797112	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	nucleotide catabolic process
REAC:R-HSA-8978868	0.00643287600397	0.428571428571	PRKAB2 PRKAG2 PRKAA2	Fatty acid metabolism
GO:1902494	0.00674355151363	1.0	PRKAG1 PRKAA2 PRKAG3 PRKAB1 PRKAG2 PRKAB2 PRKAA1	catalytic complex
GO:0046496	0.00717572690708	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	nicotinamide nucleotide metabolic process
GO:0019362	0.00717572690708	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	pyridine nucleotide metabolic process
GO:1901292	0.00742193936463	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	nucleoside phosphate catabolic process
GO:0072524	0.00819856023041	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	pyridine-containing compound metabolic process
GO:0140823	0.00983221512175	0.285714285714	PRKAA2 PRKAA1	histone H2BS36 kinase activity
GO:0140998	0.00983221512175	0.285714285714	PRKAA2 PRKAA1	histone H2B kinase activity
GO:1903943	0.00983221512175	0.285714285714	PRKAA2 PRKAA1	regulation of hepatocyte apoptotic process
GO:1903944	0.00983221512175	0.285714285714	PRKAA2 PRKAA1	negative regulation of hepatocyte apoptotic process
GO:0046434	0.0248063154794	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	organophosphate catabolic process
GO:0046034	0.0267004712888	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	ATP metabolic process
WP:WP5356	0.028073243565	0.285714285714	PRKAA2 PRKAA1	Affected pathways in Duchenne muscular dystrophy
GO:1990044	0.0294899169624	0.285714285714	PRKAA2 PRKAA1	protein localization to lipid droplet
GO:0009205	0.0353751608722	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	purine ribonucleoside triphosphate metabolic process
GO:0009144	0.0370032799768	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	purine nucleoside triphosphate metabolic process
WP:WP2034	0.039968890476	0.285714285714	PRKAA2 PRKAA1	Leptin signaling pathway
GO:0009199	0.0404265697107	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	ribonucleoside triphosphate metabolic process
GO:1901136	0.041318088432	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	carbohydrate derivative catabolic process
WP:WP4674	0.0423532804888	0.285714285714	PRKAA2 PRKAA1	Head and neck squamous cell carcinoma
GO:0019901	0.0433616477749	0.714285714286	PRKAG1 PRKAG3 PRKAB1 PRKAG2 PRKAB2	protein kinase binding
GO:0009141	0.0469790462071	0.571428571429	PRKAG1 PRKAA1 PRKAG2 PRKAA2	nucleoside triphosphate metabolic process
CORUM:771	0.0499958217778	0.142857142857	PRKAA1	NDPKA-AMPKalpha1 complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
PRKAB2	PRKAA1	1.0	0.352	mutually_exclusive (Q9Y478)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM hein () bioplex3_HCT116 fraction
PRKAB1	PRKAA1	1.0	0.266	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction
PRKAA2	PRKAB1	1.0	0.104	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction
PRKAG1	PRKAB1	1.0	0.414	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
PRKAB2	PRKAA2	1.0	0.254		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
PRKAG1	PRKAA1	1.0	0.568	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM
PRKAG2	PRKAB1	1.0	0.068	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
PRKAG1	PRKAB2	1.0	0.384		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
PRKAG2	PRKAA2	1.0	0.146	mutually_exclusive (Q9Y478)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
PRKAB2	PRKAG2	1.0	0.174		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
PRKAG2	PRKAA1	1.0	0.22		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
PRKAB2	PRKAG3	0.999			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
PRKAB1	PRKAG3	0.999		structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
PRKAA2	PRKAG3	0.999		mutually_exclusive (Q9Y478)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
PRKAG1	PRKAA2	0.999	0.146	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM
PRKAB2	PRKAB1	0.998	0.274	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
PRKAA1	PRKAG3	0.995			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
PRKAA2	PRKAA1	0.989	0.136		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
PRKAG1	PRKAG2	0.952	0.12	mutually_exclusive (Q9Y478)	bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only

Related Complexes

Genename	Complexes
PRKAG1	huMAP3_01652.1 huMAP3_12203.1
PRKAB2	huMAP3_01652.1 huMAP3_11993.1 huMAP3_12186.1 huMAP3_12203.1
PRKAG2	huMAP3_01652.1 huMAP3_12203.1
PRKAA2	huMAP3_01652.1 huMAP3_12203.1
PRKAB1	huMAP3_01652.1 huMAP3_12203.1
PRKAA1	huMAP3_01652.1 huMAP3_12203.1
PRKAG3	huMAP3_01652.1 huMAP3_12203.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_01652.1

Complex Portal: CPX-11573