hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01668.1
Complex Portal: CPX-20154
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ACTC1 | Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] | 5 | UniProt NCBI |
| CAP2 | Adenylyl cyclase-associated protein 2 (CAP 2) | 5 | UniProt NCBI |
| CAP1 | Adenylyl cyclase-associated protein 1 (CAP 1) | 5 | UniProt NCBI |
| UBC | Polyubiquitin-C [Cleaved into: Ubiquitin] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-428890 | 0.000286914834749 | 0.5 | CAP2 CAP1 | Role of ABL in ROBO-SLIT signaling |
| REAC:R-HSA-376176 | 0.00211233137107 | 0.75 | UBC CAP2 CAP1 | Signaling by ROBO receptors |
| REAC:R-HSA-422475 | 0.0253860120448 | 0.75 | UBC CAP2 CAP1 | Axon guidance |
| REAC:R-HSA-9675108 | 0.0283171453534 | 0.75 | UBC CAP2 CAP1 | Nervous system development |
| GO:0008179 | 0.042122686785 | 0.5 | CAP2 CAP1 | adenylate cyclase binding |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CAP2 | CAP1 | 1.0 | 0.416 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| CAP2 | UBC | 0.993 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ACTC1 | CAP2 | 0.991 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CAP1 | UBC | 0.591 | bioplex3_WMM WMM_only boldt_WMM | ||
| ACTC1 | CAP1 | 0.342 |
mutually_exclusive (P40123)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| ACTC1 | UBC | 0.023 | bioplex3_WMM WMM_only boldt_WMM |
Related Complexes