hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_01672.1
Complex Portal: CPX-18457
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PFKFB2 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (6PF-2-K/Fru-2,6-P2ase 2) (PFK/FBPase 2) (6PF-2-K/Fru-2,6-P2ase heart-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)] | 5 | UniProt NCBI |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (6PF-2-K/Fru-2,6-P2ase 4) (PFK/FBPase 4) (6PF-2-K/Fru-2,6-P2ase testis-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)] | 5 | UniProt NCBI |
| PFKFB1 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (6PF-2-K/Fru-2,6-P2ase 1) (PFK/FBPase 1) (6PF-2-K/Fru-2,6-P2ase liver isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)] | 5 | UniProt NCBI |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (6PF-2-K/Fru-2,6-P2ase 3) (PFK/FBPase 3) (6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme) (Renal carcinoma antigen NY-REN-56) (iPFK-2) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9634600 | 1.02652471053e-07 | 1.0 | PFKFB2 PFKFB4 PFKFB3 | Regulation of glycolysis by fructose 2,6-bisphosphate metabolism |
| KEGG:00051 | 3.12599090109e-07 | 1.0 | PFKFB2 PFKFB4 PFKFB3 | Fructose and mannose metabolism |
| GO:0003873 | 3.84480164306e-07 | 1.0 | PFKFB2 PFKFB4 PFKFB3 | 6-phosphofructo-2-kinase activity |
| GO:0006003 | 3.84480164306e-07 | 1.0 | PFKFB2 PFKFB4 PFKFB3 | fructose 2,6-bisphosphate metabolic process |
| GO:0004331 | 9.61200410764e-07 | 1.0 | PFKFB2 PFKFB4 PFKFB3 | fructose-2,6-bisphosphate 2-phosphatase activity |
| GO:0008443 | 3.36420143768e-06 | 1.0 | PFKFB2 PFKFB4 PFKFB3 | phosphofructokinase activity |
| GO:0050308 | 5.38272230028e-06 | 1.0 | PFKFB2 PFKFB4 PFKFB3 | sugar-phosphatase activity |
| GO:0019203 | 8.07408345042e-06 | 1.0 | PFKFB2 PFKFB4 PFKFB3 | carbohydrate phosphatase activity |
| KEGG:04152 | 1.22310662704e-05 | 1.0 | PFKFB2 PFKFB4 PFKFB3 | AMPK signaling pathway |
| REAC:R-HSA-70171 | 2.03811815253e-05 | 1.0 | PFKFB2 PFKFB4 PFKFB3 | Glycolysis |
| REAC:R-HSA-70326 | 3.68984307198e-05 | 1.0 | PFKFB2 PFKFB4 PFKFB3 | Glucose metabolism |
| GO:0019200 | 0.000109576846827 | 1.0 | PFKFB2 PFKFB4 PFKFB3 | carbohydrate kinase activity |
| WP:WP3932 | 0.000194681531196 | 1.0 | PFKFB2 PFKFB4 PFKFB3 | Focal adhesion PI3K Akt mTOR signaling pathway |
| REAC:R-HSA-71387 | 0.0012894643491 | 1.0 | PFKFB2 PFKFB4 PFKFB3 | Metabolism of carbohydrates |
| KEGG:01100 | 0.0189521995452 | 1.0 | PFKFB2 PFKFB4 PFKFB3 | Metabolic pathways |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PFKFB4 | PFKFB3 | 0.997 | 0.086 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PFKFB2 | PFKFB3 | 0.996 | 0.052 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PFKFB2 | PFKFB4 | 0.987 | 0.062 |
mutually_exclusive (P16118)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt_WMM WMM_only |
| PFKFB4 | PFKFB1 | 0.98 |
mutually_exclusive (O60825)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PFKFB2 | PFKFB1 | 0.415 |
mutually_exclusive (Q16877)
structurally_consistent (dimer) |
bioplex3_WMM WMM_only | |
| PFKFB1 | PFKFB3 | 0.278 | bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| PFKFB2 | huMAP3_01672.1 huMAP3_04537.1 huMAP3_06971.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1 |
| PFKFB4 | huMAP3_01672.1 huMAP3_13106.1 |
| PFKFB1 | huMAP3_01672.1 huMAP3_13106.1 |
| PFKFB3 | huMAP3_01672.1 huMAP3_14445.1 huMAP3_14656.1 |