hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_01673.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GSTM4 | Glutathione S-transferase Mu 4 (EC 2.5.1.18) (GST class-mu 4) (GST-Mu2) (GSTM4-4) (Leukotriene C4 synthase GSTM4) (EC 4.4.1.20) | 5 | UniProt NCBI |
| GSTM1 | Glutathione S-transferase Mu 1 (EC 2.5.1.18) (GST HB subunit 4) (GST class-mu 1) (GSTM1-1) (GSTM1a-1a) (GSTM1b-1b) (GTH4) | 5 | UniProt NCBI |
| GSTM5 | Glutathione S-transferase Mu 5 (EC 2.5.1.18) (GST class-mu 5) (GSTM5-5) | 5 | UniProt NCBI |
| GSTM3 | Glutathione S-transferase Mu 3 (EC 2.5.1.18) (GST class-mu 3) (GSTM3-3) (hGSTM3-3) | 5 | UniProt NCBI |
| GSTM2 | Glutathione S-transferase Mu 2 (EC 2.5.1.18) (GST class-mu 2) (GSTM2-2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-156590 | 5.88723446898e-12 | 1.0 | GSTM1 GSTM3 GSTM2 GSTM4 GSTM5 | Glutathione conjugation |
| KEGG:00480 | 1.85224691322e-11 | 1.0 | GSTM1 GSTM3 GSTM2 GSTM4 GSTM5 | Glutathione metabolism |
| KEGG:05204 | 2.50871508956e-11 | 1.0 | GSTM1 GSTM3 GSTM2 GSTM4 GSTM5 | Chemical carcinogenesis - DNA adducts |
| KEGG:00982 | 2.76470642523e-11 | 1.0 | GSTM1 GSTM3 GSTM2 GSTM4 GSTM5 | Drug metabolism - cytochrome P450 |
| KEGG:00980 | 4.37664625294e-11 | 1.0 | GSTM1 GSTM3 GSTM2 GSTM4 GSTM5 | Metabolism of xenobiotics by cytochrome P450 |
| KEGG:00983 | 8.44283859282e-11 | 1.0 | GSTM1 GSTM3 GSTM2 GSTM4 GSTM5 | Drug metabolism - other enzymes |
| KEGG:01524 | 1.05806086211e-10 | 1.0 | GSTM1 GSTM3 GSTM2 GSTM4 GSTM5 | Platinum drug resistance |
| GO:0004364 | 2.3712162925e-10 | 1.0 | GSTM1 GSTM3 GSTM2 GSTM4 GSTM5 | glutathione transferase activity |
| REAC:R-HSA-156580 | 7.02810716421e-10 | 1.0 | GSTM1 GSTM3 GSTM2 GSTM4 GSTM5 | Phase II - Conjugation of compounds |
| KEGG:05418 | 1.46474105495e-09 | 1.0 | GSTM1 GSTM3 GSTM2 GSTM4 GSTM5 | Fluid shear stress and atherosclerosis |
| WP:WP2884 | 1.5175533416e-09 | 1.0 | GSTM1 GSTM3 GSTM2 GSTM4 GSTM5 | NRF2 pathway |
| GO:0006749 | 2.50552578676e-09 | 1.0 | GSTM1 GSTM3 GSTM2 GSTM4 GSTM5 | glutathione metabolic process |
| WP:WP702 | 3.92189046469e-09 | 1.0 | GSTM1 GSTM3 GSTM2 GSTM4 GSTM5 | Metapathway biotransformation Phase I and II |
| KEGG:05225 | 6.94777952651e-09 | 1.0 | GSTM1 GSTM3 GSTM2 GSTM4 GSTM5 | Hepatocellular carcinoma |
| KEGG:05207 | 7.87918813219e-09 | 1.0 | GSTM1 GSTM3 GSTM2 GSTM4 GSTM5 | Chemical carcinogenesis - receptor activation |
| KEGG:05208 | 2.33094248458e-08 | 1.0 | GSTM1 GSTM3 GSTM2 GSTM4 GSTM5 | Chemical carcinogenesis - reactive oxygen species |
| GO:0016765 | 2.58397654225e-08 | 1.0 | GSTM1 GSTM3 GSTM2 GSTM4 GSTM5 | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| REAC:R-HSA-211859 | 2.63492330395e-08 | 1.0 | GSTM1 GSTM3 GSTM2 GSTM4 GSTM5 | Biological oxidations |
| GO:0043295 | 2.76191861336e-08 | 0.8 | GSTM1 GSTM2 GSTM4 GSTM3 | glutathione binding |
| GO:1900750 | 4.33992010508e-08 | 0.8 | GSTM1 GSTM2 GSTM4 GSTM3 | oligopeptide binding |
| WP:WP2882 | 9.0223929241e-08 | 1.0 | GSTM1 GSTM3 GSTM2 GSTM4 GSTM5 | Nuclear receptors meta pathway |
| GO:0045171 | 2.02936594367e-07 | 1.0 | GSTM1 GSTM3 GSTM2 GSTM4 GSTM5 | intercellular bridge |
| GO:0042178 | 4.02274655956e-07 | 0.8 | GSTM1 GSTM2 GSTM4 GSTM3 | xenobiotic catabolic process |
| GO:0018916 | 9.61200410764e-07 | 0.6 | GSTM1 GSTM2 GSTM3 | nitrobenzene metabolic process |
| KEGG:05200 | 1.25701281056e-06 | 1.0 | GSTM1 GSTM3 GSTM2 GSTM4 GSTM5 | Pathways in cancer |
| GO:0006575 | 1.5086832866e-06 | 1.0 | GSTM1 GSTM3 GSTM2 GSTM4 GSTM5 | cellular modified amino acid metabolic process |
| GO:0070458 | 9.61003071434e-06 | 0.6 | GSTM1 GSTM2 GSTM3 | cellular detoxification of nitrogen compound |
| GO:0051410 | 9.61003071434e-06 | 0.6 | GSTM1 GSTM2 GSTM3 | detoxification of nitrogen compound |
| GO:0006790 | 5.97436292687e-05 | 1.0 | GSTM1 GSTM3 GSTM2 GSTM4 GSTM5 | sulfur compound metabolic process |
| GO:0072341 | 8.87760174517e-05 | 0.8 | GSTM1 GSTM2 GSTM4 GSTM3 | modified amino acid binding |
| KEGG:01100 | 0.000265328202954 | 1.0 | GSTM1 GSTM3 GSTM2 GSTM4 GSTM5 | Metabolic pathways |
| GO:0006805 | 0.00029151492518 | 0.8 | GSTM1 GSTM2 GSTM4 GSTM3 | xenobiotic metabolic process |
| GO:0042537 | 0.000537554131189 | 0.6 | GSTM1 GSTM2 GSTM3 | benzene-containing compound metabolic process |
| GO:0071466 | 0.000727710984203 | 0.8 | GSTM1 GSTM2 GSTM4 GSTM3 | cellular response to xenobiotic stimulus |
| WP:WP100 | 0.000798299856649 | 0.4 | GSTM1 GSTM2 | Glutathione metabolism |
| GO:0042759 | 0.00127603542925 | 0.6 | GSTM1 GSTM4 GSTM2 | long-chain fatty acid biosynthetic process |
| GO:0009410 | 0.00206012733421 | 0.8 | GSTM1 GSTM2 GSTM4 GSTM3 | response to xenobiotic stimulus |
| GO:1901681 | 0.00211972422452 | 0.8 | GSTM1 GSTM2 GSTM4 GSTM3 | sulfur compound binding |
| REAC:R-HSA-1430728 | 0.00423241276191 | 1.0 | GSTM1 GSTM3 GSTM2 GSTM4 GSTM5 | Metabolism |
| GO:1990748 | 0.00807957978043 | 0.6 | GSTM1 GSTM2 GSTM3 | cellular detoxification |
| TF:M06731 | 0.00875197805683 | 0.6 | GSTM1 GSTM2 GSTM5 | Factor: znf302; motif: NGGGCATGSTGM |
| GO:0097237 | 0.0094606249379 | 0.6 | GSTM1 GSTM2 GSTM3 | cellular response to toxic substance |
| GO:0006518 | 0.00983194280049 | 1.0 | GSTM1 GSTM3 GSTM2 GSTM4 GSTM5 | peptide metabolic process |
| GO:0042277 | 0.0102422643766 | 0.8 | GSTM1 GSTM2 GSTM4 GSTM3 | peptide binding |
| GO:0098754 | 0.0224016609185 | 0.6 | GSTM1 GSTM2 GSTM3 | detoxification |
| GO:0033218 | 0.0230362545099 | 0.8 | GSTM1 GSTM2 GSTM4 GSTM3 | amide binding |
| GO:0043603 | 0.0398244546538 | 1.0 | GSTM1 GSTM3 GSTM2 GSTM4 GSTM5 | amide metabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GSTM4 | GSTM2 | 1.0 | 0.114 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GSTM3 | GSTM2 | 1.0 | 0.516 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GSTM4 | GSTM3 | 0.999 | 0.172 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GSTM5 | GSTM2 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GSTM5 | GSTM3 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GSTM4 | GSTM5 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GSTM1 | GSTM2 | 0.984 | 0.108 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| GSTM1 | GSTM5 | 0.972 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GSTM4 | GSTM1 | 0.633 | 0.286 | bioplex3_WMM WMM_only |
| GSTM1 | GSTM3 | 0.23 | 0.168 | bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| GSTM4 | huMAP3_01673.1 huMAP3_14934.1 |
| GSTM1 | huMAP3_01673.1 huMAP3_13858.1 huMAP3_14934.1 |
| GSTM5 | huMAP3_01673.1 huMAP3_14445.1 huMAP3_14656.1 huMAP3_14934.1 |
| GSTM3 | huMAP3_01673.1 huMAP3_14934.1 |
| GSTM2 | huMAP3_01673.1 huMAP3_14934.1 |