hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01678.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EIF4E1B | Eukaryotic translation initiation factor 4E type 1B | 2 | UniProt NCBI |
| EIF4G3 | Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII) | 5 | UniProt NCBI |
| EIF4EBP1 | Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I) | 5 | UniProt NCBI |
| EIF4E | Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4566 | 3.71869501007e-06 | 0.75 | EIF4G3 EIF4E EIF4EBP1 | Translation inhibitors in chronically activated PDGFRA cells |
| WP:WP107 | 6.42448863831e-06 | 0.75 | EIF4G3 EIF4E EIF4EBP1 | Translation factors |
| KEGG:01521 | 2.21720662311e-05 | 0.75 | EIF4EBP1 EIF4E1B EIF4E | EGFR tyrosine kinase inhibitor resistance |
| KEGG:04211 | 2.91718888289e-05 | 0.75 | EIF4EBP1 EIF4E1B EIF4E | Longevity regulating pathway |
| KEGG:04066 | 5.35787298046e-05 | 0.75 | EIF4EBP1 EIF4E1B EIF4E | HIF-1 signaling pathway |
| GO:0016281 | 0.000109904886398 | 0.75 | EIF4G3 EIF4E1B EIF4E | eukaryotic translation initiation factor 4F complex |
| KEGG:04910 | 0.000111034102003 | 0.75 | EIF4EBP1 EIF4E1B EIF4E | Insulin signaling pathway |
| GO:0045182 | 0.000151907686653 | 1.0 | EIF4G3 EIF4E EIF4E1B EIF4EBP1 | translation regulator activity |
| KEGG:04150 | 0.000180381602802 | 0.75 | EIF4EBP1 EIF4E1B EIF4E | mTOR signaling pathway |
| GO:0034518 | 0.000215165225046 | 0.75 | EIF4G3 EIF4E1B EIF4E | RNA cap binding complex |
| GO:0000339 | 0.000313494264121 | 0.75 | EIF4G3 EIF4E1B EIF4E | RNA cap binding |
| WP:WP516 | 0.000390164573598 | 0.5 | EIF4EBP1 EIF4E | Hypertrophy model |
| WP:WP3879 | 0.000535373329556 | 0.5 | EIF4EBP1 EIF4E | 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression |
| WP:WP3932 | 0.000866797679386 | 0.75 | EIF4EBP1 EIF4E1B EIF4E | Focal adhesion PI3K Akt mTOR signaling pathway |
| WP:WP4172 | 0.001130836436 | 0.75 | EIF4EBP1 EIF4E1B EIF4E | PI3K Akt signaling pathway |
| KEGG:04151 | 0.00130520637951 | 0.75 | EIF4EBP1 EIF4E1B EIF4E | PI3K-Akt signaling pathway |
| REAC:R-HSA-166208 | 0.00282403231951 | 0.5 | EIF4EBP1 EIF4E | mTORC1-mediated signalling |
| WP:WP585 | 0.00324158330579 | 0.5 | EIF4EBP1 EIF4E | Interferon type I signaling pathways |
| GO:0003743 | 0.00508133939815 | 0.75 | EIF4G3 EIF4E1B EIF4E | translation initiation factor activity |
| WP:WP2034 | 0.00578263137464 | 0.5 | EIF4EBP1 EIF4E | Leptin signaling pathway |
| WP:WP4674 | 0.00612927993034 | 0.5 | EIF4EBP1 EIF4E | Head and neck squamous cell carcinoma |
| WP:WP4806 | 0.00781315318354 | 0.5 | EIF4EBP1 EIF4E | EGFR tyrosine kinase inhibitor resistance |
| REAC:R-HSA-165159 | 0.00837722051003 | 0.5 | EIF4EBP1 EIF4E | MTOR signalling |
| WP:WP2263 | 0.0113062844995 | 0.5 | EIF4EBP1 EIF4E1B | Androgen receptor network in prostate cancer |
| WP:WP3915 | 0.0162815495406 | 0.5 | EIF4EBP1 EIF4E | Angiopoietin like protein 8 regulatory pathway |
| REAC:R-HSA-72662 | 0.0180511544442 | 0.5 | EIF4EBP1 EIF4E | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| WP:WP2380 | 0.01895043011 | 0.5 | EIF4EBP1 EIF4E | Brain derived neurotrophic factor BDNF signaling pathway |
| GO:0008135 | 0.0209740664347 | 0.75 | EIF4G3 EIF4E1B EIF4E | translation factor activity, RNA binding |
| REAC:R-HSA-1169408 | 0.0218635493976 | 0.5 | EIF4G3 EIF4E | ISG15 antiviral mechanism |
| WP:WP481 | 0.0255965717397 | 0.5 | EIF4EBP1 EIF4E | Insulin signaling |
| REAC:R-HSA-1169410 | 0.0260384914588 | 0.5 | EIF4G3 EIF4E | Antiviral mechanism by IFN-stimulated genes |
| WP:WP5115 | 0.0365498826325 | 0.5 | EIF4EBP1 EIF4E | Network map of SARS CoV 2 signaling pathway |
| GO:0090079 | 0.0378152735667 | 0.75 | EIF4G3 EIF4E1B EIF4E | translation regulator activity, nucleic acid binding |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| EIF4E | EIF4G3 | 0.999 | 0.21 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction |
| EIF4EBP1 | EIF4E | 0.998 | 0.1384 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| EIF4E1B | EIF4E | 0.982 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| EIF4E1B | EIF4EBP1 | 0.977 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| EIF4EBP1 | EIF4G3 | 0.908 | 0.148 | bioplex_WMM bioplex3_WMM WMM_only |
| EIF4E1B | EIF4G3 | 0.675 | bioplex3_WMM WMM_only |
Related Complexes