hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_01680.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DICER1 | Endoribonuclease Dicer (EC 3.1.26.3) (Helicase with RNase motif) (Helicase MOI) | 5 | UniProt NCBI |
| TARBP2 | RISC-loading complex subunit TARBP2 (TAR RNA-binding protein 2) (Trans-activation-responsive RNA-binding protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5381 | 5.12628525639e-06 | 1.0 | DICER1 TARBP2 | RNA-induced silencing complex, RISC |
| CORUM:5377 | 5.12628525639e-06 | 1.0 | DICER1 TARBP2 | RNA-induced silencing complex, RISC |
| WP:WP2338 | 6.38455527386e-06 | 1.0 | DICER1 TARBP2 | miRNA biogenesis |
| CORUM:3032 | 1.02525705128e-05 | 1.0 | DICER1 TARBP2 | RNA-induced silencing complex, RISC |
| CORUM:5378 | 2.56314262819e-05 | 1.0 | DICER1 TARBP2 | TRBP containing complex (DICER, TRBP, AGO2, RPL7A, EIF6, MOV10) |
| REAC:R-HSA-426486 | 6.15154230766e-05 | 1.0 | DICER1 TARBP2 | Small interfering RNA (siRNA) biogenesis |
| WP:WP4844 | 0.000185152102942 | 1.0 | DICER1 TARBP2 | Influence of laminopathies on Wnt signaling |
| REAC:R-HSA-203927 | 0.000432316723289 | 1.0 | DICER1 TARBP2 | MicroRNA (miRNA) biogenesis |
| WP:WP4879 | 0.000460113616736 | 1.0 | DICER1 TARBP2 | Overlap between signal transduction pathways contributing to LMNA laminopathies |
| GO:0098795 | 0.00140460216025 | 1.0 | DICER1 TARBP2 | global gene silencing by mRNA cleavage |
| WP:WP4549 | 0.00255169392445 | 1.0 | DICER1 TARBP2 | Fragile X syndrome |
| REAC:R-HSA-211000 | 0.0117955823749 | 1.0 | DICER1 TARBP2 | Gene Silencing by RNA |
| WP:WP2943 | 0.0124400931326 | 0.5 | DICER1 | Hypoxia mediated EMT and stemness |
| GO:0030422 | 0.0131096201623 | 1.0 | DICER1 TARBP2 | siRNA processing |
| GO:0070578 | 0.0131096201623 | 1.0 | DICER1 TARBP2 | RISC-loading complex |
| GO:0035197 | 0.0131096201623 | 1.0 | DICER1 TARBP2 | siRNA binding |
| GO:0070883 | 0.016855225923 | 1.0 | DICER1 TARBP2 | pre-miRNA binding |
| GO:0070922 | 0.0210690324038 | 1.0 | DICER1 TARBP2 | RISC complex assembly |
| WP:WP2805 | 0.0373151717536 | 0.5 | DICER1 | exRNA mechanism of action and biogenesis |
| GO:0031332 | 0.0426062655276 | 1.0 | DICER1 TARBP2 | RNAi effector complex |
| GO:0016442 | 0.0426062655276 | 1.0 | DICER1 TARBP2 | RISC complex |
| HP:0030983 | 0.0499436884913 | 0.5 | DICER1 | Ovarian thecoma |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| DICER1 | TARBP2 | 0.997 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () boldt_WMM treiber_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| DICER1 | huMAP3_01680.1 huMAP3_06571.1 huMAP3_06694.1 huMAP3_07613.1 huMAP3_07712.1 huMAP3_09317.1 |
| TARBP2 | huMAP3_01680.1 huMAP3_07613.1 huMAP3_08465.1 |