hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01683.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RAD1 | Cell cycle checkpoint protein RAD1 (hRAD1) (Rad1-like DNA damage checkpoint protein) | 5 | UniProt NCBI |
| RAD9A | Cell cycle checkpoint control protein RAD9A (hRAD9) (EC 3.1.11.2) (DNA repair exonuclease rad9 homolog A) | 5 | UniProt NCBI |
| ZBTB14 | Zinc finger and BTB domain-containing protein 14 (Zinc finger protein 161 homolog) (Zfp-161) (Zinc finger protein 478) (Zinc finger protein 5 homolog) (ZF5) (Zfp-5) (hZF5) | 5 | UniProt NCBI |
| HUS1 | Checkpoint protein HUS1 (hHUS1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2809 | 7.01606139244e-10 | 0.75 | RAD9A RAD1 HUS1 | 9-1-1 complex |
| CORUM:267 | 7.01606139244e-10 | 0.75 | RAD9A RAD1 HUS1 | 9-1-1 complex |
| CORUM:271 | 7.01606139244e-10 | 0.75 | RAD9A RAD1 HUS1 | 9-1-1 complex |
| CORUM:275 | 7.01606139244e-10 | 0.75 | RAD9A RAD1 HUS1 | 9-1-1 complex |
| CORUM:276 | 7.01606139244e-10 | 0.75 | RAD9A RAD1 HUS1 | 9-1-1 complex |
| CORUM:2196 | 7.01606139244e-10 | 0.75 | RAD9A RAD1 HUS1 | 9-1-1-LIG1 complex |
| CORUM:2808 | 7.01606139244e-10 | 0.75 | RAD9A RAD1 HUS1 | 9-1-1-APE1 complex |
| CORUM:2197 | 2.80628050973e-09 | 0.75 | RAD9A RAD1 HUS1 | 9-1-1-FEN1 complex |
| CORUM:6728 | 2.80628050973e-09 | 0.75 | RAD9A RAD1 HUS1 | 9-1-1-RHINO complex |
| CORUM:2198 | 2.80628050973e-09 | 0.75 | RAD9A RAD1 HUS1 | 9-1-1-POLB complex |
| WP:WP3875 | 1.95685123169e-08 | 0.75 | RAD9A RAD1 HUS1 | ATR signaling |
| CORUM:274 | 3.92798604902e-08 | 0.75 | RAD9A RAD1 HUS1 | 9-1-1-RAD17-RFC complex |
| CORUM:268 | 3.92798604902e-08 | 0.75 | RAD9A RAD1 HUS1 | 9-1-1-RAD17-RFC complex |
| GO:0030896 | 1.53784171933e-06 | 0.75 | RAD9A RAD1 HUS1 | checkpoint clamp complex |
| CORUM:6733 | 5.12628525639e-06 | 0.5 | RAD1 HUS1 | 9b-1-1 complex |
| REAC:R-HSA-9709570 | 8.38346160394e-06 | 0.75 | RAD9A RAD1 HUS1 | Impaired BRCA2 binding to RAD51 |
| REAC:R-HSA-5685938 | 9.16893973468e-06 | 0.75 | RAD9A RAD1 HUS1 | HDR through Single Strand Annealing (SSA) |
| REAC:R-HSA-176187 | 1.00019654619e-05 | 0.75 | RAD9A RAD1 HUS1 | Activation of ATR in response to replication stress |
| REAC:R-HSA-5693616 | 1.28002609524e-05 | 0.75 | RAD9A RAD1 HUS1 | Presynaptic phase of homologous DNA pairing and strand exchange |
| REAC:R-HSA-9701190 | 1.38374083551e-05 | 0.75 | RAD9A RAD1 HUS1 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function |
| REAC:R-HSA-9675136 | 1.38374083551e-05 | 0.75 | RAD9A RAD1 HUS1 | Diseases of DNA Double-Strand Break Repair |
| REAC:R-HSA-5693579 | 1.60766305396e-05 | 0.75 | RAD9A RAD1 HUS1 | Homologous DNA Pairing and Strand Exchange |
| WP:WP4016 | 2.54708175834e-05 | 0.75 | RAD9A RAD1 HUS1 | DNA IR damage and cellular response via ATR |
| REAC:R-HSA-9675135 | 2.57917427086e-05 | 0.75 | RAD9A RAD1 HUS1 | Diseases of DNA repair |
| REAC:R-HSA-5685942 | 6.40033583955e-05 | 0.75 | RAD9A RAD1 HUS1 | HDR through Homologous Recombination (HRR) |
| REAC:R-HSA-69473 | 0.000148092217351 | 0.75 | RAD9A RAD1 HUS1 | G2/M DNA damage checkpoint |
| KEGG:04218 | 0.000152567450385 | 0.75 | RAD9A RAD1 HUS1 | Cellular senescence |
| REAC:R-HSA-6804756 | 0.000158650980172 | 0.75 | RAD9A RAD1 HUS1 | Regulation of TP53 Activity through Phosphorylation |
| REAC:R-HSA-5693607 | 0.000164113242291 | 0.75 | RAD9A RAD1 HUS1 | Processing of DNA double-strand break ends |
| REAC:R-HSA-5693567 | 0.000422025999557 | 0.75 | RAD9A RAD1 HUS1 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-5693538 | 0.000487256563506 | 0.75 | RAD9A RAD1 HUS1 | Homology Directed Repair |
| REAC:R-HSA-5633007 | 0.000799005459147 | 0.75 | RAD9A RAD1 HUS1 | Regulation of TP53 Activity |
| REAC:R-HSA-5693532 | 0.000897810107574 | 0.75 | RAD9A RAD1 HUS1 | DNA Double-Strand Break Repair |
| REAC:R-HSA-69481 | 0.000915028341188 | 0.75 | RAD9A RAD1 HUS1 | G2/M Checkpoints |
| REAC:R-HSA-69620 | 0.00495341247057 | 0.75 | RAD9A RAD1 HUS1 | Cell Cycle Checkpoints |
| WP:WP1530 | 0.00528146385782 | 0.5 | RAD9A RAD1 | miRNA regulation of DNA damage response |
| WP:WP707 | 0.00528146385782 | 0.5 | RAD9A RAD1 | DNA damage response |
| GO:0000794 | 0.00582352741409 | 0.75 | RAD9A RAD1 HUS1 | condensed nuclear chromosome |
| REAC:R-HSA-73894 | 0.00653220236003 | 0.75 | RAD9A RAD1 HUS1 | DNA Repair |
| GO:0071479 | 0.0079870728422 | 0.75 | RAD9A RAD1 HUS1 | cellular response to ionizing radiation |
| REAC:R-HSA-3700989 | 0.00879681508035 | 0.75 | RAD9A RAD1 HUS1 | Transcriptional Regulation by TP53 |
| GO:0010212 | 0.0378152735667 | 0.75 | RAD9A RAD1 HUS1 | response to ionizing radiation |
| CORUM:6734 | 0.049938562206 | 0.25 | RAD1 | 9b-1b-1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| HUS1 | RAD1 | 1.0 | 0.666 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RAD9A | RAD1 | 1.0 | 0.186 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RAD1 | ZBTB14 | 1.0 | 0.144 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RAD9A | HUS1 | 0.999 | 0.272 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| HUS1 | ZBTB14 | 0.994 | 0.09 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| RAD9A | ZBTB14 | 0.993 | 0.09 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes