hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_01722.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CTBP2 | C-terminal-binding protein 2 (CtBP2) | 5 | UniProt NCBI |
| CTBP1 | C-terminal-binding protein 1 (CtBP1) (EC 1.1.1.-) | 5 | UniProt NCBI |
| ZBTB42 | Zinc finger and BTB domain-containing protein 42 | 5 | UniProt NCBI |
| ZBTB18 | Zinc finger and BTB domain-containing protein 18 (58 kDa repressor protein) (Transcriptional repressor RP58) (Translin-associated zinc finger protein 1) (TAZ-1) (Zinc finger protein 238) (Zinc finger protein C2H2-171) | 5 | UniProt NCBI |
| ZNF516 | Zinc finger protein 516 | 5 | UniProt NCBI |
| ZEB2 | Zinc finger E-box-binding homeobox 2 (Smad-interacting protein 1) (SMADIP1) (Zinc finger homeobox protein 1b) | 5 | UniProt NCBI |
| ZNF536 | Zinc finger protein 536 | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:642 | 4.56610637912e-09 | 0.571428571429 | CTBP2 ZEB2 ZNF516 CTBP1 | CtBP complex |
| CORUM:2921 | 6.1565588648e-05 | 0.285714285714 | CTBP2 CTBP1 | SHARP-CtBP complex |
| REAC:R-HSA-5339700 | 0.00011430200373 | 0.285714285714 | CTBP2 CTBP1 | Signaling by TCF7L2 mutants |
| CORUM:643 | 0.000737776422886 | 0.285714285714 | CTBP2 CTBP1 | CtBP core complex |
| REAC:R-HSA-4641265 | 0.00209171533568 | 0.285714285714 | CTBP2 CTBP1 | Repression of WNT target genes |
| GO:0140110 | 0.00271308272393 | 1.0 | ZBTB18 CTBP2 ZNF536 ZNF516 CTBP1 ZEB2 ZBTB42 | transcription regulator activity |
| WP:WP268 | 0.0111348137492 | 0.285714285714 | CTBP2 CTBP1 | Notch signaling |
| KEGG:04330 | 0.0114560548 | 0.285714285714 | CTBP2 CTBP1 | Notch signaling pathway |
| REAC:R-HSA-4791275 | 0.0199798926111 | 0.285714285714 | CTBP2 CTBP1 | Signaling by WNT in cancer |
| KEGG:05220 | 0.0272691209555 | 0.285714285714 | CTBP2 CTBP1 | Chronic myeloid leukemia |
| HP:0009918 | 0.0315332858987 | 0.285714285714 | CTBP1 ZEB2 | Ectopia pupillae |
| WP:WP4336 | 0.0473257570206 | 0.285714285714 | CTBP2 CTBP1 | ncRNAs involved in Wnt signaling in hepatocellular carcinoma |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CTBP1 | CTBP2 | 0.999 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () Malo fraction boldt_WMM | |
| ZBTB42 | CTBP2 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ZNF516 | CTBP1 | 0.998 | 0.188 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| CTBP1 | ZBTB18 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CTBP1 | ZBTB42 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ZNF516 | ZBTB18 | 0.994 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ZBTB18 | CTBP2 | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| ZBTB18 | ZBTB42 | 0.99 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ZNF516 | CTBP2 | 0.977 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| ZNF536 | CTBP1 | 0.973 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | |
| ZEB2 | CTBP1 | 0.956 | 0.108 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM |
| ZNF516 | ZBTB42 | 0.838 | 0.07 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| ZNF536 | ZEB2 | 0.587 | 0.116 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| ZEB2 | ZBTB18 | 0.513 | bioplex_WMM bioplex3_WMM WMM_only | |
| ZNF516 | ZEB2 | 0.417 | 0.174 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| ZNF536 | ZBTB18 | 0.35 | bioplex_WMM bioplex3_WMM WMM_only | |
| ZNF536 | ZNF516 | 0.303 | 0.048 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| ZEB2 | CTBP2 | 0.3 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| ZNF536 | CTBP2 | 0.263 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes