hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01759.1
Complex Portal: CPX-25082
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| BHLHE23 | Class E basic helix-loop-helix protein 23 (bHLHe23) (Class B basic helix-loop-helix protein 4) (bHLHb4) | 3 | UniProt NCBI |
| PCGF5 | Polycomb group RING finger protein 5 (RING finger protein 159) | 5 | UniProt NCBI |
| CSNK2A2 | Casein kinase II subunit alpha' (CK II alpha') (EC 2.7.11.1) | 5 | UniProt NCBI |
| PHRF1 | PHD and RING finger domain-containing protein 1 | 4 | UniProt NCBI |
| RNF111 | E3 ubiquitin-protein ligase Arkadia (EC 2.3.2.27) (RING finger protein 111) (hRNF111) (RING-type E3 ubiquitin transferase Arkadia) | 5 | UniProt NCBI |
| HIRIP3 | HIRA-interacting protein 3 | 5 | UniProt NCBI |
| CSNK2A1 | Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1) | 5 | UniProt NCBI |
| CSNK2B | Casein kinase II subunit beta (CK II beta) (Phosvitin) (Protein G5a) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2720 | 9.82248594942e-09 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | Casein kinase II (beta-dimer, alpha, alpha') |
| CORUM:5224 | 9.82248594942e-09 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | Casein kinase II (beta-dimer, alpha, alpha') |
| CORUM:2719 | 3.92798604902e-08 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | Casein kinase II-HMG1 complex |
| CORUM:938 | 9.81744484776e-08 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | FACT complex, UV-activated |
| REAC:R-HSA-8939243 | 4.58458786424e-07 | 0.5 | CSNK2A2 PCGF5 CSNK2B CSNK2A1 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
| REAC:R-HSA-8934903 | 1.28104605335e-06 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | Receptor Mediated Mitophagy |
| REAC:R-HSA-201688 | 1.28104605335e-06 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | WNT mediated activation of DVL |
| REAC:R-HSA-2514853 | 3.77160472982e-06 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | Condensation of Prometaphase Chromosomes |
| GO:0005956 | 5.38272230028e-06 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | protein kinase CK2 complex |
| REAC:R-HSA-445144 | 1.55196545534e-05 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | Signal transduction by L1 |
| CORUM:5223 | 2.39226645298e-05 | 0.25 | CSNK2A2 CSNK2B | Casein kinase II (beta-dimer, alpha'-dimer) |
| CORUM:5225 | 2.39226645298e-05 | 0.25 | CSNK2B CSNK2A1 | Casein kinase II (beta-dimer, alpha-dimer) |
| REAC:R-HSA-1483191 | 4.03573329385e-05 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | Synthesis of PC |
| REAC:R-HSA-5205647 | 5.92028436306e-05 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | Mitophagy |
| REAC:R-HSA-6814122 | 0.000148687552241 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
| GO:0031519 | 0.000204451735761 | 0.5 | CSNK2A2 PCGF5 CSNK2B CSNK2A1 | PcG protein complex |
| KEGG:03008 | 0.000325559186101 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | Ribosome biogenesis in eukaryotes |
| KEGG:04064 | 0.000429284776931 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | NF-kappa B signaling pathway |
| KEGG:05235 | 0.000429284776931 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| KEGG:04520 | 0.000533899657075 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | Adherens junction |
| REAC:R-HSA-8878171 | 0.000601043221997 | 0.5 | CSNK2A2 PCGF5 CSNK2B CSNK2A1 | Transcriptional regulation by RUNX1 |
| WP:WP4336 | 0.000625219299609 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | ncRNAs involved in Wnt signaling in hepatocellular carcinoma |
| KEGG:04137 | 0.000791024458035 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | Mitophagy - animal |
| WP:WP4258 | 0.0008841301296 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | lncRNA in canonical Wnt signaling and colorectal cancer |
| REAC:R-HSA-8948751 | 0.00112890181744 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | Regulation of PTEN stability and activity |
| REAC:R-HSA-9663891 | 0.00151831565434 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | Selective autophagy |
| WP:WP428 | 0.00159618281405 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | Wnt signaling |
| KEGG:05162 | 0.00160212912447 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | Measles |
| REAC:R-HSA-390466 | 0.00221515749645 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | Chaperonin-mediated protein folding |
| REAC:R-HSA-6804756 | 0.00254432714295 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | Regulation of TP53 Activity through Phosphorylation |
| REAC:R-HSA-391251 | 0.00281136504087 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | Protein folding |
| KEGG:04310 | 0.00282902841102 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | Wnt signaling pathway |
| WP:WP4630 | 0.00288213281831 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | Measles virus infection |
| WP:WP4262 | 0.00364116708552 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | Breast cancer pathway |
| REAC:R-HSA-373760 | 0.00383396745007 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | L1CAM interactions |
| REAC:R-HSA-9755511 | 0.00406418842136 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | KEAP1-NFE2L2 pathway |
| REAC:R-HSA-1483206 | 0.00418264558662 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | Glycerophospholipid biosynthesis |
| REAC:R-HSA-1632852 | 0.00722341689363 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | Macroautophagy |
| REAC:R-HSA-6807070 | 0.00887815261922 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | PTEN Regulation |
| REAC:R-HSA-9612973 | 0.0101093243859 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | Autophagy |
| KEGG:05020 | 0.0121225246333 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | Prion disease |
| REAC:R-HSA-5633007 | 0.0126485048308 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | Regulation of TP53 Activity |
| REAC:R-HSA-212436 | 0.0167421784996 | 0.625 | CSNK2A2 CSNK2A1 PCGF5 CSNK2B RNF111 | Generic Transcription Pathway |
| WP:WP2059 | 0.0187811159917 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | Alzheimer 39 s disease and miRNA effects |
| WP:WP5124 | 0.0187811159917 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | Alzheimer 39 s disease |
| REAC:R-HSA-1483257 | 0.0195675241377 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | Phospholipid metabolism |
| REAC:R-HSA-9711123 | 0.0219710844704 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | Cellular response to chemical stress |
| REAC:R-HSA-68877 | 0.0265275467245 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | Mitotic Prometaphase |
| REAC:R-HSA-73857 | 0.0284039231402 | 0.625 | CSNK2A2 CSNK2A1 PCGF5 CSNK2B RNF111 | RNA Polymerase II Transcription |
| REAC:R-HSA-201681 | 0.0316626496625 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | TCF dependent signaling in response to WNT |
| KEGG:05010 | 0.0317191137546 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | Alzheimer disease |
| GO:0075342 | 0.0393180950424 | 0.25 | CSNK2B CSNK2A1 | symbiont-mediated disruption of host cell PML body |
| GO:0052111 | 0.0393180950424 | 0.25 | CSNK2B CSNK2A1 | symbiont-mediated disruption of host anatomical structure |
| GO:0052008 | 0.0393180950424 | 0.25 | CSNK2B CSNK2A1 | symbiont-mediated disruption of host cellular anatomical entity |
| KEGG:03083 | 0.0411542607239 | 0.25 | CSNK2B PCGF5 | Polycomb repressive complex |
| REAC:R-HSA-1257604 | 0.0432383769232 | 0.375 | CSNK2A2 CSNK2A1 CSNK2B | PIP3 activates AKT signaling |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CSNK2A1 | CSNK2B | 1.0 | 0.962 | hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| CSNK2A2 | CSNK2A1 | 1.0 | 0.704 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| CSNK2A2 | CSNK2B | 1.0 | 0.842 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM | |
| PCGF5 | CSNK2B | 1.0 | 0.174 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 boldt_WMM | |
| PCGF5 | CSNK2A2 | 0.999 | 0.306 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 boldt_WMM |
| PCGF5 | CSNK2A1 | 0.999 | 0.216 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 boldt_WMM | |
| CSNK2A2 | HIRIP3 | 0.998 | 0.086 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| HIRIP3 | CSNK2A1 | 0.997 | 0.118 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| HIRIP3 | CSNK2B | 0.994 | 0.138 | bioplex3_HEK293 bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| RNF111 | CSNK2B | 0.991 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| PHRF1 | CSNK2B | 0.989 | 0.234 | bioplex3_HEK293 bioplex3_WMM youn_WMM bioplex3_HCT116 boldt_WMM WMM_only | |
| BHLHE23 | CSNK2A2 | 0.986 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| PHRF1 | CSNK2A2 | 0.984 | 0.225666666667 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | |
| BHLHE23 | CSNK2B | 0.977 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| CSNK2A2 | RNF111 | 0.975 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| BHLHE23 | CSNK2A1 | 0.972 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| PHRF1 | RNF111 | 0.965 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PHRF1 | CSNK2A1 | 0.962 | 0.112 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM boldt_WMM WMM_only | |
| PHRF1 | PCGF5 | 0.952 | 0.074 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| PCGF5 | RNF111 | 0.949 |
mutually_exclusive (P19784)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| RNF111 | CSNK2A1 | 0.745 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| RNF111 | HIRIP3 | 0.533 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PCGF5 | HIRIP3 | 0.36 | 0.09 |
mutually_exclusive (P19784)
|
bioplex_WMM bioplex3_WMM WMM_only |
| PHRF1 | HIRIP3 | 0.297 | 0.038 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes