hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01805.1
Complex Portal: CPX-19399
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CASKIN2 | Caskin-2 (CASK-interacting protein 2) | 3 | UniProt NCBI |
| ABL2 | Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG) | 5 | UniProt NCBI |
| NHS | Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) | 5 | UniProt NCBI |
| SEMA6A | Semaphorin-6A (Semaphorin VIA) (Sema VIA) (Semaphorin-6A-1) (SEMA6A-1) | 5 | UniProt NCBI |
| NCK1 | SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha) | 5 | UniProt NCBI |
| NCK2 | Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04012 | 0.0128243509281 | 0.4 | ABL2 NCK2 | ErbB signaling pathway |
| WP:WP673 | 0.0188521857166 | 0.4 | ABL2 NCK2 | ErbB signaling pathway |
| REAC:R-HSA-9012999 | 0.0303172193635 | 0.6 | NCK2 ABL2 NHS | RHO GTPase cycle |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| NCK1 | NCK2 | 1.0 | 0.084 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| NHS | NCK2 | 0.988 | 0.096 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| NCK2 | CASKIN2 | 0.984 | 0.156 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NCK1 | NHS | 0.976 | 0.15 | bioplex3_HEK293 bioplex3_WMM gupta_WMM WMM_only | |
| SEMA6A | NCK2 | 0.965 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | ||
| NCK2 | ABL2 | 0.964 | 0.044 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | |
| NCK1 | CASKIN2 | 0.862 | 0.0742666666667 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| NCK1 | ABL2 | 0.769 | 0.204 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| CASKIN2 | ABL2 | 0.531 | 0.254 | bioplex_WMM bioplex3_WMM WMM_only | |
| NCK1 | SEMA6A | 0.45 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | ||
| SEMA6A | CASKIN2 | 0.233 | bioplex_WMM bioplex3_WMM WMM_only | ||
| NHS | CASKIN2 | 0.175 | 0.116 | bioplex3_WMM WMM_only | |
| SEMA6A | ABL2 | 0.133 | bioplex_WMM bioplex3_WMM WMM_only | ||
| NHS | ABL2 | 0.117 | 0.13 | bioplex3_WMM WMM_only | |
| NHS | SEMA6A | 0.098 | bioplex3_WMM WMM_only |
Related Complexes