hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01810.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| INTS6 | Integrator complex subunit 6 (Int6) (DBI-1) (Protein DDX26) (Protein deleted in cancer 1) (DICE1) | 5 | UniProt NCBI |
| INTS3 | Integrator complex subunit 3 (Int3) (SOSS complex subunit A) (Sensor of single-strand DNA complex subunit A) (SOSS-A) (Sensor of ssDNA subunit A) | 5 | UniProt NCBI |
| INIP | SOSS complex subunit C (INTS3- and NABP-interacting protein) (Sensor of single-strand DNA complex subunit C) (Sensor of ssDNA subunit C) (SOSS-C) (Single-stranded DNA-binding protein-interacting protein 1) (SSB-interacting protein 1) (hSSBIP1) | 5 | UniProt NCBI |
| NABP2 | SOSS complex subunit B1 (Nucleic acid-binding protein 2) (Oligonucleotide/oligosaccharide-binding fold-containing protein 2B) (Sensor of single-strand DNA complex subunit B1) (Sensor of ssDNA subunit B1) (SOSS-B1) (Single-stranded DNA-binding protein 1) (hSSB1) | 5 | UniProt NCBI |
| INTS6L | Integrator complex subunit 6-like (Protein DDX26B) | 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0070876 | 3.84440695359e-06 | 0.6 | INTS3 NABP2 INIP | SOSS complex |
| REAC:R-HSA-6807505 | 0.00018480745401 | 0.6 | INTS6 NABP2 INTS3 | RNA polymerase II transcribes snRNA genes |
| CORUM:1153 | 0.000899678549321 | 0.4 | INTS6 INTS3 | Integrator complex |
| GO:0032039 | 0.000929874009882 | 0.6 | INTS6 INTS6L INTS3 | integrator complex |
| CORUM:1155 | 0.00106311089559 | 0.4 | INTS6 INTS3 | Integrator-RNAPII complex |
| GO:0016180 | 0.00249322401434 | 0.6 | INTS6 INTS6L INTS3 | snRNA processing |
| GO:0044818 | 0.0145266888919 | 0.6 | INTS3 NABP2 INIP | mitotic G2/M transition checkpoint |
| GO:0016073 | 0.0211358171848 | 0.6 | INTS6 INTS6L INTS3 | snRNA metabolic process |
| GO:0010972 | 0.0250826699056 | 0.6 | INTS3 NABP2 INIP | negative regulation of G2/M transition of mitotic cell cycle |
| GO:1902750 | 0.0279690439474 | 0.6 | INTS3 NABP2 INIP | negative regulation of cell cycle G2/M phase transition |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NABP2 | INTS3 | 1.0 | 0.33 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () Malo bioplex3_HCT116 fraction |
| INIP | NABP2 | 1.0 | 0.282 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () Malo bioplex3_HCT116 fraction |
| INIP | INTS3 | 0.999 | 0.396 | hein_WMM bioplex_WMM bioplex3_WMM Malo fraction |
| NABP2 | INTS6 | 0.985 | 0.198 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| NABP2 | INTS6L | 0.978 | 0.056 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| INTS6 | INTS3 | 0.971 | 0.308 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| INTS6L | INTS6 | 0.84 | 0.06 | bioplex3_WMM WMM_only |
| INIP | INTS6 | 0.802 | 0.158 | hein_WMM bioplex3_WMM WMM_only |
| INTS6L | INTS3 | 0.761 | 0.092 | bioplex3_WMM WMM_only |
| INIP | INTS6L | 0.72 | 0.108 | bioplex3_WMM WMM_only |
Related Complexes