hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_01811.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| KRT6A | Keratin, type II cytoskeletal 6A (Cytokeratin-6A) (CK-6A) (Cytokeratin-6D) (CK-6D) (Keratin-6A) (K6A) (Type-II keratin Kb6) (allergen Hom s 5) | 5 | UniProt NCBI |
| KRT6B | Keratin, type II cytoskeletal 6B (Cytokeratin-6B) (CK-6B) (Keratin-6B) (K6B) (Type-II keratin Kb10) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0025248 | 2.05051410255e-05 | 1.0 | KRT6A KRT6B | Eruptive vellus hair cyst |
| HP:0012035 | 2.05051410255e-05 | 1.0 | KRT6A KRT6B | Steatocystoma multiplex |
| HP:0030268 | 3.41752350426e-05 | 1.0 | KRT6A KRT6B | Hyperplastic callus formation |
| HP:0007490 | 3.41752350426e-05 | 1.0 | KRT6A KRT6B | Linear arrays of macular hyperkeratoses in flexural areas |
| HP:0008401 | 5.12628525639e-05 | 1.0 | KRT6A KRT6B | Onychogryposis of toenails |
| HP:0040036 | 9.56906581192e-05 | 1.0 | KRT6A KRT6B | Onychogryposis of fingernail |
| HP:0007446 | 0.000123030846153 | 1.0 | KRT6A KRT6B | Palmoplantar blistering |
| HP:0030318 | 0.000153788557692 | 1.0 | KRT6A KRT6B | Angular cheilitis |
| HP:0007410 | 0.000187963792734 | 1.0 | KRT6A KRT6B | Palmoplantar hyperhidrosis |
| HP:0006089 | 0.000225556551281 | 1.0 | KRT6A KRT6B | Palmar hyperhidrosis |
| HPA:0461403 | 0.000261783178967 | 1.0 | KRT6A KRT6B | skin 1; cells in corneal layer[High] |
| HPA:0471403 | 0.000317750617229 | 1.0 | KRT6A KRT6B | skin 2; cells in corneal layer[High] |
| HP:0100798 | 0.000358839967947 | 1.0 | KRT6A KRT6B | Fingernail dysplasia |
| HP:0030766 | 0.000358839967947 | 1.0 | KRT6A KRT6B | Ear pain |
| HP:0200040 | 0.000358839967947 | 1.0 | KRT6A KRT6B | Epidermoid cyst |
| HP:0001818 | 0.000410102820511 | 1.0 | KRT6A KRT6B | Paronychia |
| HP:0025245 | 0.000717679935894 | 1.0 | KRT6A KRT6B | Cutaneous cyst |
| HP:0100803 | 0.000789447929484 | 1.0 | KRT6A KRT6B | Abnormality of the periungual region |
| HPA:0461402 | 0.000861176388739 | 1.0 | KRT6A KRT6B | skin 1; cells in corneal layer[>=Medium] |
| HP:0033800 | 0.000864633446577 | 1.0 | KRT6A KRT6B | Blistering by anatomical location |
| HP:0002745 | 0.00111069513888 | 1.0 | KRT6A KRT6B | Oral leukoplakia |
| HP:0025125 | 0.00111069513888 | 1.0 | KRT6A KRT6B | White lesion of the oral mucosa |
| HP:0001805 | 0.00119955074999 | 1.0 | KRT6A KRT6B | Onychogryposis |
| HP:0007502 | 0.00138751454273 | 1.0 | KRT6A KRT6B | Follicular hyperkeratosis |
| HPA:0471402 | 0.00176086800381 | 1.0 | KRT6A KRT6B | skin 2; cells in corneal layer[>=Medium] |
| HPA:0461401 | 0.00190168930008 | 1.0 | KRT6A KRT6B | skin 1; cells in corneal layer[>=Low] |
| HP:0012514 | 0.00191723068589 | 1.0 | KRT6A KRT6B | Lower limb pain |
| HP:0000695 | 0.00203342648503 | 1.0 | KRT6A KRT6B | Natal tooth |
| HP:0046506 | 0.00215303980768 | 1.0 | KRT6A KRT6B | Pain in head and neck region |
| HP:0006288 | 0.00294248773717 | 1.0 | KRT6A KRT6B | Advanced eruption of teeth |
| HP:0100825 | 0.00338334826922 | 1.0 | KRT6A KRT6B | Cheilitis |
| REAC:R-HSA-6809371 | 0.00377807223396 | 1.0 | KRT6A KRT6B | Formation of the cornified envelope |
| REAC:R-HSA-6805567 | 0.00400875507049 | 1.0 | KRT6A KRT6B | Keratinization |
| HP:0009763 | 0.00401900764101 | 1.0 | KRT6A KRT6B | Limb pain |
| HPA:0461453 | 0.00408381759188 | 1.0 | KRT6A KRT6B | skin 1; hair follicles[High] |
| HPA:0471401 | 0.00458932993748 | 1.0 | KRT6A KRT6B | skin 2; cells in corneal layer[>=Low] |
| HPA:0461413 | 0.0117369134239 | 1.0 | KRT6A KRT6B | skin 1; cells in spinous layer[High] |
| HP:0000982 | 0.0146201655512 | 1.0 | KRT6A KRT6B | Palmoplantar keratoderma |
| HP:0008066 | 0.0155839071794 | 1.0 | KRT6A KRT6B | Abnormal blistering of the skin |
| HP:0001609 | 0.0159119894358 | 1.0 | KRT6A KRT6B | Hoarse voice |
| HPA:0460183 | 0.0161258438244 | 1.0 | KRT6A KRT6B | skin 1; cells in granular layer[High] |
| HPA:0470183 | 0.0162654615198 | 1.0 | KRT6A KRT6B | skin 2; cells in granular layer[High] |
| HPA:0471413 | 0.0168299503057 | 1.0 | KRT6A KRT6B | skin 2; cells in spinous layer[High] |
| HP:0000972 | 0.0190185183012 | 1.0 | KRT6A KRT6B | Palmoplantar hyperkeratosis |
| HP:0010765 | 0.0193807757926 | 1.0 | KRT6A KRT6B | Palmar hyperkeratosis |
| HP:0007556 | 0.0197464508076 | 1.0 | KRT6A KRT6B | Plantar hyperkeratosis |
| HPA:0461452 | 0.0233384217552 | 1.0 | KRT6A KRT6B | skin 1; hair follicles[>=Medium] |
| HPA:0471393 | 0.0240136418168 | 1.0 | KRT6A KRT6B | skin 2; cells in basal layer[High] |
| HP:0008404 | 0.0260620342435 | 1.0 | KRT6A KRT6B | Nail dystrophy |
| HP:0002164 | 0.0304535519464 | 1.0 | KRT6A KRT6B | Nail dysplasia |
| HP:0100872 | 0.0327774679293 | 1.0 | KRT6A KRT6B | Abnormality of the plantar skin of foot |
| HP:0000975 | 0.0327774679293 | 1.0 | KRT6A KRT6B | Hyperhidrosis |
| HPA:0461451 | 0.0357108364136 | 1.0 | KRT6A KRT6B | skin 1; hair follicles[>=Low] |
| HP:0001231 | 0.0462390930126 | 1.0 | KRT6A KRT6B | Abnormal fingernail morphology |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| KRT6A | KRT6B | 0.964 | 0.48 | hein_WMM youn_WMM gupta_WMM WMM_only boldt_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| KRT6A | huMAP3_01811.1 huMAP3_11343.1 huMAP3_11964.1 |
| KRT6B | huMAP3_01811.1 huMAP3_11964.1 huMAP3_15329.1 |