hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01845.1
Complex Portal: CPX-21911
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| BMF | Bcl-2-modifying factor | 5 | UniProt NCBI |
| TNIP3 | TNFAIP3-interacting protein 3 (A20-binding inhibitor of NF-kappa-B activation 3) (ABIN-3) (Listeria-induced gene protein) | 5 | UniProt NCBI |
| BCL2L2 | Bcl-2-like protein 2 (Bcl2-L-2) (Apoptosis regulator Bcl-W) | 5 | UniProt NCBI |
| BID | BH3-interacting domain death agonist (p22 BID) (BID) [Cleaved into: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domain death agonist p13 (p13 BID); BH3-interacting domain death agonist p11 (p11 BID)] | 5 | UniProt NCBI |
| BIK | Bcl-2-interacting killer (Apoptosis inducer NBK) (BIP1) (BP4) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP1772 | 2.64882854506e-05 | 0.75 | BMF BID BIK | Apoptosis modulation and signaling |
| REAC:R-HSA-111453 | 0.000368856835097 | 0.5 | BMF BID | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members |
| GO:0090200 | 0.000591522022343 | 0.75 | BMF BID BIK | positive regulation of release of cytochrome c from mitochondria |
| WP:WP3611 | 0.0022974831852 | 0.5 | BMF BID | Photodynamic therapy induced AP 1 survival signaling |
| GO:0090199 | 0.00274053853655 | 0.75 | BMF BID BIK | regulation of release of cytochrome c from mitochondria |
| REAC:R-HSA-114452 | 0.00444848198459 | 0.5 | BMF BID | Activation of BH3-only proteins |
| GO:0001836 | 0.00508133939815 | 0.75 | BMF BID BIK | release of cytochrome c from mitochondria |
| GO:0010822 | 0.0131184183431 | 0.75 | BMF BID BIK | positive regulation of mitochondrion organization |
| REAC:R-HSA-109606 | 0.0135329645116 | 0.5 | BMF BID | Intrinsic Pathway for Apoptosis |
| GO:0008637 | 0.0291371139957 | 0.75 | BMF BID BIK | apoptotic mitochondrial changes |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TNIP3 | BCL2L2 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| BCL2L2 | BIK | 0.994 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| BMF | BCL2L2 | 0.991 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| BCL2L2 | BID | 0.99 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| TNIP3 | BIK | 0.616 | bioplex3_WMM WMM_only | ||
| BID | BIK | 0.605 | bioplex3_WMM WMM_only | ||
| BMF | TNIP3 | 0.557 | bioplex_WMM bioplex3_WMM WMM_only | ||
| BMF | BIK | 0.214 |
mutually_exclusive (Q92843)
|
bioplex3_WMM WMM_only | |
| TNIP3 | BID | 0.175 | bioplex_WMM bioplex3_WMM WMM_only | ||
| BMF | BID | 0.164 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes