hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01848.1
Complex Portal: CPX-22449
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MAT2A | S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) (Methionine adenosyltransferase II) (MAT-II) | 5 | UniProt NCBI |
| MAT2B | Methionine adenosyltransferase 2 subunit beta (Methionine adenosyltransferase II beta) (MAT II beta) (Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase) | 5 | UniProt NCBI |
| MAT1A | S-adenosylmethionine synthase isoform type-1 (AdoMet synthase 1) (EC 2.5.1.6) (Methionine adenosyltransferase 1) (MAT 1) (Methionine adenosyltransferase I/III) (MAT-I/III) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP704 | 7.75161621584e-10 | 1.0 | MAT2B MAT2A MAT1A | Methylation pathways |
| REAC:R-HSA-156581 | 3.91945798564e-08 | 1.0 | MAT2B MAT2A MAT1A | Methylation |
| WP:WP3580 | 8.83684248606e-08 | 1.0 | MAT2B MAT2A MAT1A | Methionine de novo and salvage pathway |
| GO:0048269 | 9.61200410764e-08 | 1.0 | MAT2B MAT2A MAT1A | methionine adenosyltransferase complex |
| GO:0006556 | 3.84480164306e-07 | 1.0 | MAT2B MAT2A MAT1A | S-adenosylmethionine biosynthetic process |
| KEGG:00270 | 7.92990338881e-07 | 1.0 | MAT2B MAT2A MAT1A | Cysteine and methionine metabolism |
| WP:WP2525 | 2.03363651423e-06 | 1.0 | MAT2B MAT2A MAT1A | Trans sulfuration one carbon metabolism and related pathways |
| KEGG:01230 | 2.50251661292e-06 | 1.0 | MAT2B MAT2A MAT1A | Biosynthesis of amino acids |
| CORUM:7191 | 3.41752350426e-06 | 0.666666666667 | MAT2B MAT2A | Methionine adenosyltransferase alpha2 beta-v1 |
| GO:0046500 | 8.07408345042e-06 | 1.0 | MAT2B MAT2A MAT1A | S-adenosylmethionine metabolic process |
| KEGG:01240 | 2.04821359703e-05 | 1.0 | MAT2B MAT2A MAT1A | Biosynthesis of cofactors |
| REAC:R-HSA-156580 | 3.83360319167e-05 | 1.0 | MAT2B MAT2A MAT1A | Phase II - Conjugation of compounds |
| WP:WP4292 | 4.07657496791e-05 | 0.666666666667 | MAT2B MAT1A | Methionine metabolism leading to sulfur amino acids and related disorders |
| WP:WP241 | 0.000312323469599 | 0.666666666667 | MAT2B MAT1A | One carbon metabolism |
| REAC:R-HSA-211859 | 0.000330616079734 | 1.0 | MAT2B MAT2A MAT1A | Biological oxidations |
| WP:WP3940 | 0.00102095428698 | 0.666666666667 | MAT1A MAT2A | One carbon metabolism and related pathways |
| GO:0004478 | 0.00140460216025 | 0.666666666667 | MAT1A MAT2A | methionine adenosyltransferase activity |
| KEGG:01100 | 0.0189521995452 | 1.0 | MAT2B MAT2A MAT1A | Metabolic pathways |
| CORUM:7197 | 0.0249718442456 | 0.333333333333 | MAT1A | Methionine adenosyltransferase alpha1 beta-v1 |
| GO:0044272 | 0.0351938724399 | 1.0 | MAT2B MAT2A MAT1A | sulfur compound biosynthetic process |
| WP:WP5420 | 0.0379798583444 | 0.666666666667 | MAT2B MAT1A | ADHD and autism ASD linked metabolic pathways and SNP |
| REAC:R-HSA-5579024 | 0.0498224659464 | 0.333333333333 | MAT1A | Defective MAT1A causes MATD |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MAT2A | MAT2B | 1.0 | 0.558 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 fraction boldt_WMM treiber_WMM | |
| MAT1A | MAT2B | 0.998 | 0.682 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction | |
| MAT2A | MAT1A | 0.996 | 0.734 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
Related Complexes