hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_01849.1

Complex Portal: CPX-19281

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
CDK5RAP2	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215)	5	UniProt NCBI
AKAP1	A-kinase anchor protein 1, mitochondrial (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein 84) (S-AKAP84)	5	UniProt NCBI
AKAP11	A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11)	5	UniProt NCBI
PRKACA	cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11)	5	UniProt NCBI
PRKAR1B	cAMP-dependent protein kinase type I-beta regulatory subunit	5	UniProt NCBI
PRKX	cAMP-dependent protein kinase catalytic subunit PRKX (PrKX) (Protein kinase X) (Protein kinase X-linked) (Serine/threonine-protein kinase PRKX) (EC 2.7.11.1) (Protein kinase PKX1)	5	UniProt NCBI
CRYBG3	Very large A-kinase anchor protein (vlAKAP) (Beta/gamma crystallin domain-containing protein 3)	5	UniProt NCBI
PRKACG	cAMP-dependent protein kinase catalytic subunit gamma (PKA C-gamma) (EC 2.7.11.11)	5	UniProt NCBI
GPR161	G-protein coupled receptor 161 (G-protein coupled receptor RE2)	5	UniProt NCBI
PRKACB	cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta) (EC 2.7.11.11)	5	UniProt NCBI
AKAP13	A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP35	3.86046355794e-10	0.6	PRKAR1B AKAP13 AKAP1 PRKACB PRKACG AKAP11	G protein signaling pathways
GO:0051018	4.03935480232e-09	0.6	PRKAR1B AKAP13 AKAP1 CRYBG3 PRKACG AKAP11	protein kinase A binding
REAC:R-HSA-442720	5.59469274597e-09	0.4	PRKAR1B PRKX PRKACB PRKACG	CREB1 phosphorylation through the activation of Adenylate Cyclase
REAC:R-HSA-111931	3.63057874925e-08	0.4	PRKAR1B PRKX PRKACB PRKACG	PKA-mediated phosphorylation of CREB
REAC:R-HSA-111997	7.25322049724e-07	0.4	PRKAR1B PRKX PRKACB PRKACG	CaM pathway
REAC:R-HSA-9664323	7.25322049724e-07	0.4	PRKAR1B PRKX PRKACB PRKACG	FCGR3A-mediated IL10 synthesis
REAC:R-HSA-111933	7.25322049724e-07	0.4	PRKAR1B PRKX PRKACB PRKACG	Calmodulin induced events
REAC:R-HSA-111996	9.51119385451e-07	0.4	PRKAR1B PRKX PRKACB PRKACG	Ca-dependent events
REAC:R-HSA-9660821	1.38352291517e-06	0.4	PRKAR1B PRKX PRKACB PRKACG	ADORA2B mediated anti-inflammatory cytokines production
REAC:R-HSA-1489509	1.55595126345e-06	0.4	PRKAR1B PRKX PRKACB PRKACG	DAG and IP3 signaling
REAC:R-HSA-112043	2.95075305606e-06	0.4	PRKAR1B PRKX PRKACB PRKACG	PLC beta mediated events
REAC:R-HSA-112040	4.69441276875e-06	0.4	PRKAR1B PRKX PRKACB PRKACG	G-protein mediated events
REAC:R-HSA-164378	1.22191993529e-05	0.3	PRKAR1B PRKACG PRKACB	PKA activation in glucagon signalling
REAC:R-HSA-9662851	1.46096587181e-05	0.4	PRKAR1B PRKX PRKACB PRKACG	Anti-inflammatory response favouring Leishmania parasite infection
REAC:R-HSA-9664433	1.46096587181e-05	0.4	PRKAR1B PRKX PRKACB PRKACG	Leishmania parasite growth and survival
REAC:R-HSA-163615	1.58792502117e-05	0.3	PRKAR1B PRKACG PRKACB	PKA activation
REAC:R-HSA-438064	2.12861862485e-05	0.4	PRKAR1B PRKX PRKACB PRKACG	Post NMDA receptor activation events
REAC:R-HSA-111885	3.71608649487e-05	0.4	PRKAR1B PRKX PRKACB PRKACG	Opioid Signalling
REAC:R-HSA-442755	4.11757689433e-05	0.4	PRKAR1B PRKX PRKACB PRKACG	Activation of NMDA receptors and postsynaptic events
WP:WP3869	5.18113283391e-05	0.3	PRKAR1B PRKACG PRKACB	Cannabinoid receptor signaling
WP:WP3965	5.85482698541e-05	0.3	PRKAR1B PRKACG PRKACB	Lipid metabolism pathway
REAC:R-HSA-180024	6.31358311141e-05	0.3	PRKAR1B PRKACG PRKACB	DARPP-32 events
REAC:R-HSA-5610787	0.000123429301917	0.4	PRKAR1B PRKACG PRKACB GPR161	Hedgehog 'off' state
REAC:R-HSA-163359	0.000161586017522	0.3	PRKAR1B PRKACG PRKACB	Glucagon signaling in metabolic regulation
KEGG:04340	0.000162356387571	0.3	PRKACB PRKACG GPR161	Hedgehog signaling pathway
WP:WP4249	0.000174278381297	0.3	PRKACB PRKACG GPR161	Hedgehog signaling pathway
GO:0004691	0.0002304395259	0.3	PRKACB PRKX PRKACG	cAMP-dependent protein kinase activity
REAC:R-HSA-5358351	0.000299946729968	0.4	PRKAR1B PRKACG PRKACB GPR161	Signaling by Hedgehog
REAC:R-HSA-432040	0.000329743401167	0.3	PRKAR1B PRKACG PRKACB	Vasopressin regulates renal water homeostasis via Aquaporins
REAC:R-HSA-9658195	0.000348450772533	0.4	PRKAR1B PRKX PRKACB PRKACG	Leishmania infection
REAC:R-HSA-9824443	0.000348450772533	0.4	PRKAR1B PRKX PRKACB PRKACG	Parasitic Infection Pathways
REAC:R-HSA-381676	0.000360527139754	0.3	PRKAR1B PRKACG PRKACB	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
REAC:R-HSA-445717	0.000393160884162	0.3	PRKAR1B PRKACG PRKACB	Aquaporin-mediated transport
REAC:R-HSA-9634597	0.000393160884162	0.3	PRKAR1B PRKACG PRKACB	GPER1 signaling
GO:0005952	0.00040312426486	0.3	PRKAR1B PRKACG PRKACB	cAMP-dependent protein kinase complex
REAC:R-HSA-388396	0.000533206617629	0.5	PRKAR1B AKAP13 PRKX PRKACB PRKACG	GPCR downstream signalling
REAC:R-HSA-983231	0.000618263826346	0.4	AKAP1 PRKACG PRKACB PRKAR1B	Factors involved in megakaryocyte development and platelet production
REAC:R-HSA-112314	0.000634112853678	0.4	PRKAR1B PRKX PRKACB PRKACG	Neurotransmitter receptors and postsynaptic signal transmission
GO:0004690	0.000644767051209	0.3	PRKACB PRKX PRKACG	cyclic nucleotide-dependent protein kinase activity
REAC:R-HSA-372790	0.00101031898311	0.5	PRKAR1B AKAP13 PRKX PRKACB PRKACG	Signaling by GPCR
REAC:R-HSA-163358	0.00101671361746	0.2	PRKACG PRKACB	PKA-mediated phosphorylation of key metabolic factors
KEGG:04928	0.00103698175782	0.3	AKAP13 PRKACG PRKACB	Parathyroid hormone synthesis, secretion and action
REAC:R-HSA-418594	0.00121361927639	0.4	PRKAR1B PRKX PRKACB PRKACG	G alpha (i) signalling events
REAC:R-HSA-8963896	0.00152451380898	0.2	PRKACG PRKACB	HDL assembly
REAC:R-HSA-112315	0.001716945174	0.4	PRKAR1B PRKX PRKACB PRKACG	Transmission across Chemical Synapses
WP:WP4540	0.00195445192925	0.3	PRKAR1B PRKACG PRKACB	Hippo signaling regulation pathways
REAC:R-HSA-9010642	0.00213354034849	0.2	PRKACG PRKACB	ROBO receptors bind AKAP5
REAC:R-HSA-422356	0.0023802481167	0.3	PRKAR1B PRKACG PRKACB	Regulation of insulin secretion
WP:WP2436	0.00272734094269	0.2	PRKACG PRKACB	Dopamine metabolism
WP:WP4541	0.00313738741595	0.3	PRKAR1B PRKACG PRKACB	Hippo Merlin signaling dysregulation
KEGG:04910	0.00361713493347	0.3	PRKAR1B PRKACG PRKACB	Insulin signaling pathway
REAC:R-HSA-9006925	0.0049187431515	0.4	PRKAR1B PRKX PRKACB PRKACG	Intracellular signaling by second messengers
WP:WP3929	0.00626678489164	0.3	PRKACB PRKX PRKACG	Chemokine signaling pathway
REAC:R-HSA-163685	0.00655835959712	0.3	PRKAR1B PRKACG PRKACB	Integration of energy metabolism
REAC:R-HSA-9634600	0.00669318453569	0.2	PRKACG PRKACB	Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
REAC:R-HSA-418555	0.00677698551461	0.3	PRKAR1B PRKACG PRKACB	G alpha (s) signalling events
REAC:R-HSA-112316	0.00779952004401	0.4	PRKAR1B PRKX PRKACB PRKACG	Neuronal System
WP:WP4941	0.00864943763047	0.2	PRKACG PRKACB	GPR143 in melanocytes and retinal pigment epithelium cells
REAC:R-HSA-392517	0.00922174626729	0.2	PRKACG PRKACB	Rap1 signalling
WP:WP5344	0.0104129071256	0.2	PRKACG PRKACB	Cardiomyocyte signaling pathways converging on Titin
REAC:R-HSA-8963898	0.0121516690115	0.2	PRKACG PRKACB	Plasma lipoprotein assembly
KEGG:05163	0.0126008892131	0.3	AKAP13 PRKACG PRKACB	Human cytomegalovirus infection
KEGG:04913	0.0132021673348	0.2	PRKACG PRKACB	Ovarian steroidogenesis
KEGG:04962	0.0163216862479	0.2	PRKACG PRKACB	Vasopressin-regulated water reabsorption
KEGG:05030	0.0171524320464	0.2	PRKACG PRKACB	Cocaine addiction
KEGG:04927	0.0180034790741	0.2	PRKACG PRKACB	Cortisol synthesis and secretion
KEGG:04923	0.0188748047605	0.2	PRKACG PRKACB	Regulation of lipolysis in adipocytes
KEGG:04742	0.0188748047605	0.2	PRKACG PRKACB	Taste transduction
REAC:R-HSA-163560	0.0192120670931	0.2	PRKACG PRKACB	Triglyceride catabolism
REAC:R-HSA-5621575	0.0192120670931	0.2	PRKACG PRKACB	CD209 (DC-SIGN) signaling
WP:WP2636	0.0203472698002	0.2	PRKACG PRKACB	Common pathways underlying drug addiction
KEGG:05110	0.0206782019073	0.2	PRKACG PRKACB	Vibrio cholerae infection
KEGG:04961	0.0225624432473	0.2	PRKACG PRKACB	Endocrine and other factor-regulated calcium reabsorption
KEGG:04924	0.0235348242361	0.2	PRKACG PRKACB	Renin secretion
KEGG:04971	0.0286984339403	0.2	PRKACG PRKACB	Gastric acid secretion
KEGG:04213	0.0297913398643	0.2	PRKACG PRKACB	Longevity regulating pathway - multiple species
KEGG:04720	0.0297913398643	0.2	PRKACG PRKACB	Long-term potentiation
WP:WP5085	0.0319043985122	0.2	PRKACG PRKACB	Vasopressin regulated water reabsorption
KEGG:05031	0.0331900226994	0.2	PRKACG PRKACB	Amphetamine addiction
KEGG:04976	0.0343628308557	0.2	PRKACG PRKACB	Bile secretion
KEGG:04918	0.0367681840975	0.2	PRKACG PRKACB	Thyroid hormone synthesis
GO:0097546	0.0417546094154	0.3	PRKAR1B PRKACG PRKACB	ciliary base
KEGG:04970	0.0418172146224	0.2	PRKACG PRKACB	Salivary secretion
KEGG:04911	0.0431289933515	0.2	PRKACG PRKACB	Insulin secretion
REAC:R-HSA-8853659	0.04382523057	0.2	PRKACG PRKACB	RET signaling
KEGG:04727	0.0458118206891	0.2	PRKACG PRKACB	GABAergic synapse
KEGG:04912	0.047182824951	0.2	PRKACG PRKACB	GnRH signaling pathway
KEGG:05032	0.047182824951	0.2	PRKACG PRKACB	Morphine addiction
KEGG:04750	0.0485735267376	0.2	PRKACG PRKACB	Inflammatory mediator regulation of TRP channels
REAC:R-HSA-8979227	0.0499343626014	0.2	PRKACG PRKACB	Triglyceride metabolism

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
PRKACA	GPR161	1.0
AKAP11	PRKACB	1.0	0.06
PRKAR1B	GPR161	1.0
PRKACG	GPR161	1.0
PRKAR1B	PRKACB	1.0	0.192	structurally_consistent (dimer)
PRKAR1B	PRKACA	0.999	0.088
PRKACA	PRKACB	0.999	0.754	structurally_consistent (dimer)
GPR161	PRKACB	0.999
AKAP1	PRKACB	0.999	0.038	structurally_consistent (dimer)
PRKAR1B	AKAP11	0.998	0.154
CDK5RAP2	PRKACB	0.998	0.042
AKAP1	PRKACA	0.997	0.02	mutually_exclusive (P22694)
PRKAR1B	PRKACG	0.996		structurally_consistent (dimer)
PRKX	PRKACB	0.995	0.076
CDK5RAP2	PRKACA	0.995	0.032
PRKACG	PRKACB	0.994
PRKACB	AKAP13	0.994	0.124
AKAP11	PRKACA	0.992	0.056
PRKX	AKAP13	0.992	0.182
AKAP11	PRKACG	0.991
PRKACA	PRKACG	0.99		mutually_exclusive (P31323)
AKAP1	PRKX	0.989	0.192
PRKAR1B	AKAP13	0.988	0.04
AKAP11	PRKX	0.986	0.08
PRKAR1B	PRKX	0.986	0.06	mutually_exclusive (P13861)
CDK5RAP2	AKAP11	0.985	0.126
PRKAR1B	CDK5RAP2	0.984	0.108
CDK5RAP2	AKAP13	0.98	0.156
PRKACA	AKAP13	0.977	0.022
CDK5RAP2	CRYBG3	0.974	0.152
CDK5RAP2	PRKX	0.973	0.128
PRKAR1B	AKAP1	0.971	0.05
PRKACA	CRYBG3	0.968	0.07
CRYBG3	PRKACB	0.961	0.04
CRYBG3	AKAP13	0.952	0.108
PRKACA	PRKX	0.952	0.086
AKAP11	GPR161	0.925
PRKAR1B	CRYBG3	0.891	0.128
AKAP11	AKAP13	0.882	0.05
AKAP1	AKAP11	0.879	0.048
AKAP1	AKAP13	0.869	0.048
AKAP1	PRKACG	0.868
CRYBG3	PRKACG	0.747
AKAP11	CRYBG3	0.731	0.064
AKAP1	CRYBG3	0.671	0.046
PRKACG	AKAP13	0.264
CDK5RAP2	GPR161	0.234
PRKX	CRYBG3	0.188	0.07
AKAP1	GPR161	0.187
CDK5RAP2	PRKACG	0.178
CDK5RAP2	AKAP1	0.147	0.206
CRYBG3	GPR161	0.136
PRKX	PRKACG	0.121

Related Complexes

Genename	Complexes
CDK5RAP2	huMAP3_01849.1 huMAP3_07046.1 huMAP3_11135.1 huMAP3_13352.1 huMAP3_14681.1
AKAP1	huMAP3_01849.1 huMAP3_07046.1 huMAP3_09492.1 huMAP3_10129.1 huMAP3_11135.1 huMAP3_11770.1 huMAP3_13352.1 huMAP3_14681.1
AKAP11	huMAP3_01849.1 huMAP3_07046.1 huMAP3_11135.1 huMAP3_12803.1 huMAP3_13352.1 huMAP3_14681.1
PRKACA	huMAP3_01849.1 huMAP3_07046.1 huMAP3_11135.1 huMAP3_13352.1 huMAP3_14681.1
PRKAR1B	huMAP3_00274.1 huMAP3_01849.1 huMAP3_07046.1 huMAP3_09248.1 huMAP3_11135.1 huMAP3_12803.1 huMAP3_13352.1 huMAP3_14681.1
PRKX	huMAP3_01849.1 huMAP3_07046.1 huMAP3_11135.1 huMAP3_11343.1 huMAP3_13352.1 huMAP3_14681.1
CRYBG3	huMAP3_01849.1 huMAP3_06349.1 huMAP3_06932.1 huMAP3_11135.1 huMAP3_13352.1 huMAP3_14681.1
PRKACG	huMAP3_01849.1 huMAP3_04417.1 huMAP3_07046.1 huMAP3_10543.1 huMAP3_11135.1 huMAP3_13352.1 huMAP3_14681.1
GPR161	huMAP3_01849.1 huMAP3_06349.1 huMAP3_06823.1 huMAP3_11135.1 huMAP3_12803.1 huMAP3_13352.1 huMAP3_13764.1 huMAP3_14681.1
PRKACB	huMAP3_01849.1 huMAP3_07046.1 huMAP3_11135.1 huMAP3_13352.1 huMAP3_14681.1
AKAP13	huMAP3_01849.1 huMAP3_07046.1 huMAP3_11135.1 huMAP3_13352.1 huMAP3_14681.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_01849.1

Complex Portal: CPX-19281