List of Gene Names or Uniprot ACCs (ex. OFD1 PCM1 Q1MSJ5):

Enrichment (ex. cilium):

Protein (ex. Centrosomal protein):

Complex: huMAP3_01849.1

Confidence: Extremely High   ?

Proteins

Genename	Protein Name	Uniprot Annotation Score	Links
CDK5RAP2	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215)	5	UniProt   NCBI
AKAP1	A-kinase anchor protein 1, mitochondrial (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein 84) (S-AKAP84)	5	UniProt   NCBI
AKAP11	A-kinase anchor protein 11 (AKAP-11) (A-kinase anchor protein 220 kDa) (AKAP 220) (hAKAP220) (Protein kinase A-anchoring protein 11) (PRKA11)	5	UniProt   NCBI
PRKACA	cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11)	5	UniProt   NCBI
PRKAR1B	cAMP-dependent protein kinase type I-beta regulatory subunit	5	UniProt   NCBI
PRKX	cAMP-dependent protein kinase catalytic subunit PRKX (PrKX) (Protein kinase X) (Protein kinase X-linked) (Serine/threonine-protein kinase PRKX) (EC 2.7.11.1) (Protein kinase PKX1)	5	UniProt   NCBI
CRYBG3	Very large A-kinase anchor protein (vlAKAP) (Beta/gamma crystallin domain-containing protein 3)	5	UniProt   NCBI
PRKACG	cAMP-dependent protein kinase catalytic subunit gamma (PKA C-gamma) (EC 2.7.11.11)	5	UniProt   NCBI
GPR161	G-protein coupled receptor 161 (G-protein coupled receptor RE2)	5	UniProt   NCBI
PRKACB	cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta) (EC 2.7.11.11)	5	UniProt   NCBI
AKAP13	A-kinase anchor protein 13 (AKAP-13) (AKAP-Lbc) (Breast cancer nuclear receptor-binding auxiliary protein) (Guanine nucleotide exchange factor Lbc) (Human thyroid-anchoring protein 31) (Lymphoid blast crisis oncogene) (LBC oncogene) (Non-oncogenic Rho GTPase-specific GTP exchange factor) (Protein kinase A-anchoring protein 13) (PRKA13) (p47)	5	UniProt   NCBI



Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP35	3.86046355794e-10	0.6	AKAP13 AKAP11 PRKACG AKAP1 PRKAR1B PRKACB	G protein signaling pathways
GO:0051018	4.03935480232e-09	0.6	AKAP13 AKAP11 PRKACG AKAP1 CRYBG3 PRKAR1B	protein kinase A binding
REAC:R-HSA-442720	5.59469274597e-09	0.4	PRKAR1B PRKACB PRKX PRKACG	CREB1 phosphorylation through the activation of Adenylate Cyclase
REAC:R-HSA-111931	3.63057874925e-08	0.4	PRKAR1B PRKACB PRKX PRKACG	PKA-mediated phosphorylation of CREB
REAC:R-HSA-111997	7.25322049724e-07	0.4	PRKAR1B PRKACB PRKX PRKACG	CaM pathway
REAC:R-HSA-9664323	7.25322049724e-07	0.4	PRKAR1B PRKACB PRKX PRKACG	FCGR3A-mediated IL10 synthesis
REAC:R-HSA-111933	7.25322049724e-07	0.4	PRKAR1B PRKACB PRKX PRKACG	Calmodulin induced events
REAC:R-HSA-111996	9.51119385451e-07	0.4	PRKAR1B PRKACB PRKX PRKACG	Ca-dependent events
REAC:R-HSA-9660821	1.38352291517e-06	0.4	PRKAR1B PRKACB PRKX PRKACG	ADORA2B mediated anti-inflammatory cytokines production
REAC:R-HSA-1489509	1.55595126345e-06	0.4	PRKAR1B PRKACB PRKX PRKACG	DAG and IP3 signaling
REAC:R-HSA-112043	2.95075305606e-06	0.4	PRKAR1B PRKACB PRKX PRKACG	PLC beta mediated events
REAC:R-HSA-112040	4.69441276875e-06	0.4	PRKAR1B PRKACB PRKX PRKACG	G-protein mediated events
REAC:R-HSA-164378	1.22191993529e-05	0.3	PRKAR1B PRKACG PRKACB	PKA activation in glucagon signalling
REAC:R-HSA-9662851	1.46096587181e-05	0.4	PRKAR1B PRKACB PRKX PRKACG	Anti-inflammatory response favouring Leishmania parasite infection
REAC:R-HSA-9664433	1.46096587181e-05	0.4	PRKAR1B PRKACB PRKX PRKACG	Leishmania parasite growth and survival
REAC:R-HSA-163615	1.58792502117e-05	0.3	PRKAR1B PRKACG PRKACB	PKA activation
REAC:R-HSA-438064	2.12861862485e-05	0.4	PRKAR1B PRKACB PRKX PRKACG	Post NMDA receptor activation events
REAC:R-HSA-111885	3.71608649487e-05	0.4	PRKAR1B PRKACB PRKX PRKACG	Opioid Signalling
REAC:R-HSA-442755	4.11757689433e-05	0.4	PRKAR1B PRKACB PRKX PRKACG	Activation of NMDA receptors and postsynaptic events
WP:WP3869	5.18113283391e-05	0.3	PRKAR1B PRKACG PRKACB	Cannabinoid receptor signaling
WP:WP3965	5.85482698541e-05	0.3	PRKAR1B PRKACG PRKACB	Lipid metabolism pathway
REAC:R-HSA-180024	6.31358311141e-05	0.3	PRKAR1B PRKACG PRKACB	DARPP-32 events
REAC:R-HSA-5610787	0.000123429301917	0.4	PRKAR1B PRKACB PRKACG GPR161	Hedgehog 'off' state
REAC:R-HSA-163359	0.000161586017522	0.3	PRKAR1B PRKACG PRKACB	Glucagon signaling in metabolic regulation
KEGG:04340	0.000162356387571	0.3	PRKACB PRKACG GPR161	Hedgehog signaling pathway
WP:WP4249	0.000174278381297	0.3	PRKACB PRKACG GPR161	Hedgehog signaling pathway
GO:0004691	0.0002304395259	0.3	PRKACB PRKX PRKACG	cAMP-dependent protein kinase activity
REAC:R-HSA-5358351	0.000299946729968	0.4	PRKAR1B PRKACB PRKACG GPR161	Signaling by Hedgehog
REAC:R-HSA-432040	0.000329743401167	0.3	PRKAR1B PRKACG PRKACB	Vasopressin regulates renal water homeostasis via Aquaporins
REAC:R-HSA-9658195	0.000348450772533	0.4	PRKAR1B PRKACB PRKX PRKACG	Leishmania infection
REAC:R-HSA-9824443	0.000348450772533	0.4	PRKAR1B PRKACB PRKX PRKACG	Parasitic Infection Pathways
REAC:R-HSA-381676	0.000360527139754	0.3	PRKAR1B PRKACG PRKACB	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
REAC:R-HSA-445717	0.000393160884162	0.3	PRKAR1B PRKACG PRKACB	Aquaporin-mediated transport
REAC:R-HSA-9634597	0.000393160884162	0.3	PRKAR1B PRKACG PRKACB	GPER1 signaling
GO:0005952	0.00040312426486	0.3	PRKAR1B PRKACG PRKACB	cAMP-dependent protein kinase complex
REAC:R-HSA-388396	0.000533206617629	0.5	AKAP13 PRKAR1B PRKACB PRKX PRKACG	GPCR downstream signalling
REAC:R-HSA-983231	0.000618263826346	0.4	PRKAR1B PRKACB AKAP1 PRKACG	Factors involved in megakaryocyte development and platelet production
REAC:R-HSA-112314	0.000634112853678	0.4	PRKAR1B PRKACB PRKX PRKACG	Neurotransmitter receptors and postsynaptic signal transmission
GO:0004690	0.000644767051209	0.3	PRKACB PRKX PRKACG	cyclic nucleotide-dependent protein kinase activity
REAC:R-HSA-372790	0.00101031898311	0.5	AKAP13 PRKAR1B PRKACB PRKX PRKACG	Signaling by GPCR
REAC:R-HSA-163358	0.00101671361746	0.2	PRKACB PRKACG	PKA-mediated phosphorylation of key metabolic factors
KEGG:04928	0.00103698175782	0.3	PRKACB PRKACG AKAP13	Parathyroid hormone synthesis, secretion and action
REAC:R-HSA-418594	0.00121361927639	0.4	PRKAR1B PRKACB PRKX PRKACG	G alpha (i) signalling events
REAC:R-HSA-8963896	0.00152451380898	0.2	PRKACB PRKACG	HDL assembly
REAC:R-HSA-112315	0.001716945174	0.4	PRKAR1B PRKACB PRKX PRKACG	Transmission across Chemical Synapses
WP:WP4540	0.00195445192925	0.3	PRKAR1B PRKACG PRKACB	Hippo signaling regulation pathways
REAC:R-HSA-9010642	0.00213354034849	0.2	PRKACB PRKACG	ROBO receptors bind AKAP5
REAC:R-HSA-422356	0.0023802481167	0.3	PRKAR1B PRKACG PRKACB	Regulation of insulin secretion
WP:WP2436	0.00272734094269	0.2	PRKACB PRKACG	Dopamine metabolism
WP:WP4541	0.00313738741595	0.3	PRKAR1B PRKACG PRKACB	Hippo Merlin signaling dysregulation
KEGG:04910	0.00361713493347	0.3	PRKAR1B PRKACG PRKACB	Insulin signaling pathway
REAC:R-HSA-9006925	0.0049187431515	0.4	PRKAR1B PRKACB PRKX PRKACG	Intracellular signaling by second messengers
WP:WP3929	0.00626678489164	0.3	PRKACB PRKX PRKACG	Chemokine signaling pathway
REAC:R-HSA-163685	0.00655835959712	0.3	PRKAR1B PRKACG PRKACB	Integration of energy metabolism
REAC:R-HSA-9634600	0.00669318453569	0.2	PRKACB PRKACG	Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
REAC:R-HSA-418555	0.00677698551461	0.3	PRKAR1B PRKACG PRKACB	G alpha (s) signalling events
REAC:R-HSA-112316	0.00779952004401	0.4	PRKAR1B PRKACB PRKX PRKACG	Neuronal System
WP:WP4941	0.00864943763047	0.2	PRKACB PRKACG	GPR143 in melanocytes and retinal pigment epithelium cells
REAC:R-HSA-392517	0.00922174626729	0.2	PRKACB PRKACG	Rap1 signalling
WP:WP5344	0.0104129071256	0.2	PRKACB PRKACG	Cardiomyocyte signaling pathways converging on Titin
REAC:R-HSA-8963898	0.0121516690115	0.2	PRKACB PRKACG	Plasma lipoprotein assembly
KEGG:05163	0.0126008892131	0.3	PRKACB PRKACG AKAP13	Human cytomegalovirus infection
KEGG:04913	0.0132021673348	0.2	PRKACB PRKACG	Ovarian steroidogenesis
KEGG:04962	0.0163216862479	0.2	PRKACB PRKACG	Vasopressin-regulated water reabsorption
KEGG:05030	0.0171524320464	0.2	PRKACB PRKACG	Cocaine addiction
KEGG:04927	0.0180034790741	0.2	PRKACB PRKACG	Cortisol synthesis and secretion
KEGG:04923	0.0188748047605	0.2	PRKACB PRKACG	Regulation of lipolysis in adipocytes
KEGG:04742	0.0188748047605	0.2	PRKACB PRKACG	Taste transduction
REAC:R-HSA-163560	0.0192120670931	0.2	PRKACB PRKACG	Triglyceride catabolism
REAC:R-HSA-5621575	0.0192120670931	0.2	PRKACB PRKACG	CD209 (DC-SIGN) signaling
WP:WP2636	0.0203472698002	0.2	PRKACB PRKACG	Common pathways underlying drug addiction
KEGG:05110	0.0206782019073	0.2	PRKACB PRKACG	Vibrio cholerae infection
KEGG:04961	0.0225624432473	0.2	PRKACB PRKACG	Endocrine and other factor-regulated calcium reabsorption
KEGG:04924	0.0235348242361	0.2	PRKACB PRKACG	Renin secretion
KEGG:04971	0.0286984339403	0.2	PRKACB PRKACG	Gastric acid secretion
KEGG:04213	0.0297913398643	0.2	PRKACB PRKACG	Longevity regulating pathway - multiple species
KEGG:04720	0.0297913398643	0.2	PRKACB PRKACG	Long-term potentiation
WP:WP5085	0.0319043985122	0.2	PRKACB PRKACG	Vasopressin regulated water reabsorption
KEGG:05031	0.0331900226994	0.2	PRKACB PRKACG	Amphetamine addiction
KEGG:04976	0.0343628308557	0.2	PRKACB PRKACG	Bile secretion
KEGG:04918	0.0367681840975	0.2	PRKACB PRKACG	Thyroid hormone synthesis
GO:0097546	0.0417546094154	0.3	PRKAR1B PRKACG PRKACB	ciliary base
KEGG:04970	0.0418172146224	0.2	PRKACB PRKACG	Salivary secretion
KEGG:04911	0.0431289933515	0.2	PRKACB PRKACG	Insulin secretion
REAC:R-HSA-8853659	0.04382523057	0.2	PRKACB PRKACG	RET signaling
KEGG:04727	0.0458118206891	0.2	PRKACB PRKACG	GABAergic synapse
KEGG:04912	0.047182824951	0.2	PRKACB PRKACG	GnRH signaling pathway
KEGG:05032	0.047182824951	0.2	PRKACB PRKACG	Morphine addiction
KEGG:04750	0.0485735267376	0.2	PRKACB PRKACG	Inflammatory mediator regulation of TRP channels
REAC:R-HSA-8979227	0.0499343626014	0.2	PRKACB PRKACG	Triglyceride metabolism



Edges

Protein 1	Protein 2	Score ?	ProteomeHD?
PRKACA	GPR161	1.0
AKAP11	PRKACB	1.0	0.06
PRKAR1B	GPR161	1.0
PRKACG	GPR161	1.0
PRKAR1B	PRKACB	1.0	0.192
PRKAR1B	PRKACA	0.999	0.088
PRKACA	PRKACB	0.999	0.754
GPR161	PRKACB	0.999
AKAP1	PRKACB	0.999	0.038
PRKAR1B	AKAP11	0.998	0.154
CDK5RAP2	PRKACB	0.998	0.042
AKAP1	PRKACA	0.997	0.02
PRKAR1B	PRKACG	0.996
PRKX	PRKACB	0.995	0.076
CDK5RAP2	PRKACA	0.995	0.032
PRKACG	PRKACB	0.994
PRKACB	AKAP13	0.994	0.124
AKAP11	PRKACA	0.992	0.056
PRKX	AKAP13	0.992	0.182
AKAP11	PRKACG	0.991
PRKACA	PRKACG	0.99
AKAP1	PRKX	0.989	0.192
PRKAR1B	AKAP13	0.988	0.04
AKAP11	PRKX	0.986	0.08
PRKAR1B	PRKX	0.986	0.06
CDK5RAP2	AKAP11	0.985	0.126
PRKAR1B	CDK5RAP2	0.984	0.108
CDK5RAP2	AKAP13	0.98	0.156
PRKACA	AKAP13	0.977	0.022
CDK5RAP2	CRYBG3	0.974	0.152
CDK5RAP2	PRKX	0.973	0.128
PRKAR1B	AKAP1	0.971	0.05
PRKACA	CRYBG3	0.968	0.07
CRYBG3	PRKACB	0.961	0.04
CRYBG3	AKAP13	0.952	0.108
PRKACA	PRKX	0.952	0.086
AKAP11	GPR161	0.925
PRKAR1B	CRYBG3	0.891	0.128
AKAP11	AKAP13	0.882	0.05
AKAP1	AKAP11	0.879	0.048
AKAP1	AKAP13	0.869	0.048
AKAP1	PRKACG	0.868
CRYBG3	PRKACG	0.747
AKAP11	CRYBG3	0.731	0.064
AKAP1	CRYBG3	0.671	0.046
PRKACG	AKAP13	0.264
CDK5RAP2	GPR161	0.234
PRKX	CRYBG3	0.188	0.07
AKAP1	GPR161	0.187
CDK5RAP2	PRKACG	0.178
CDK5RAP2	AKAP1	0.147	0.206
CRYBG3	GPR161	0.136
PRKX	PRKACG	0.121





Related Complexes

Genename	Complexes
CDK5RAP2	huMAP3_01849.1 huMAP3_07046.1 huMAP3_11135.1 huMAP3_13352.1 huMAP3_14681.1
AKAP1	huMAP3_01849.1 huMAP3_07046.1 huMAP3_09492.1 huMAP3_10129.1 huMAP3_11135.1 huMAP3_11770.1 huMAP3_13352.1 huMAP3_14681.1
AKAP11	huMAP3_01849.1 huMAP3_07046.1 huMAP3_11135.1 huMAP3_12803.1 huMAP3_13352.1 huMAP3_14681.1
PRKACA	huMAP3_01849.1 huMAP3_07046.1 huMAP3_11135.1 huMAP3_13352.1 huMAP3_14681.1
PRKAR1B	huMAP3_00274.1 huMAP3_01849.1 huMAP3_07046.1 huMAP3_09248.1 huMAP3_11135.1 huMAP3_12803.1 huMAP3_13352.1 huMAP3_14681.1
PRKX	huMAP3_01849.1 huMAP3_07046.1 huMAP3_11135.1 huMAP3_11343.1 huMAP3_13352.1 huMAP3_14681.1
CRYBG3	huMAP3_01849.1 huMAP3_06349.1 huMAP3_06932.1 huMAP3_11135.1 huMAP3_13352.1 huMAP3_14681.1
PRKACG	huMAP3_01849.1 huMAP3_04417.1 huMAP3_07046.1 huMAP3_10543.1 huMAP3_11135.1 huMAP3_13352.1 huMAP3_14681.1
GPR161	huMAP3_01849.1 huMAP3_06349.1 huMAP3_06823.1 huMAP3_11135.1 huMAP3_12803.1 huMAP3_13352.1 huMAP3_13764.1 huMAP3_14681.1
PRKACB	huMAP3_01849.1 huMAP3_07046.1 huMAP3_11135.1 huMAP3_13352.1 huMAP3_14681.1
AKAP13	huMAP3_01849.1 huMAP3_07046.1 huMAP3_11135.1 huMAP3_13352.1 huMAP3_14681.1