hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01868.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| USP39 | Ubiquitin carboxyl-terminal hydrolase 39 (EC 3.4.19.12) (SAD1 homolog) (U4/U6.U5 tri-snRNP-associated 65 kDa protein) | 5 | UniProt NCBI |
| DDX23 | Probable ATP-dependent RNA helicase DDX23 (EC 3.6.4.13) (100 kDa U5 snRNP-specific protein) (DEAD box protein 23) (PRP28 homolog) (U5-100kD) | 5 | UniProt NCBI |
| TUT1 | Speckle targeted PIP5K1A-regulated poly(A) polymerase (Star-PAP) (EC 2.7.7.19) (RNA-binding motif protein 21) (RNA-binding protein 21) (U6 snRNA-specific terminal uridylyltransferase 1) (U6-TUTase) (EC 2.7.7.52) | 5 | UniProt NCBI |
| SNRPG | Small nuclear ribonucleoprotein G (snRNP-G) (Sm protein G) (Sm-G) (SmG) | 5 | UniProt NCBI |
| CENATAC | Centrosomal AT-AC splicing factor (Coiled-coil domain-containing protein 84) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03040 | 0.0002928242891 | 0.6 | USP39 SNRPG DDX23 | Spliceosome |
| GO:0006397 | 0.000307237822094 | 1.0 | USP39 TUT1 CENATAC SNRPG DDX23 | mRNA processing |
| CORUM:351 | 0.0011586928604 | 0.6 | USP39 SNRPG DDX23 | Spliceosome |
| GO:0016071 | 0.00384557561421 | 1.0 | USP39 TUT1 CENATAC SNRPG DDX23 | mRNA metabolic process |
| REAC:R-HSA-72163 | 0.00407681863898 | 0.6 | USP39 SNRPG DDX23 | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 0.00451677062682 | 0.6 | USP39 SNRPG DDX23 | mRNA Splicing |
| GO:0046540 | 0.00573353417253 | 0.6 | USP39 SNRPG DDX23 | U4/U6 x U5 tri-snRNP complex |
| GO:0097526 | 0.00573353417253 | 0.6 | USP39 SNRPG DDX23 | spliceosomal tri-snRNP complex |
| REAC:R-HSA-72203 | 0.0102904130445 | 0.6 | USP39 SNRPG DDX23 | Processing of Capped Intron-Containing Pre-mRNA |
| REAC:R-HSA-72165 | 0.0170393864121 | 0.4 | DDX23 SNRPG | mRNA Splicing - Minor Pathway |
| GO:0006396 | 0.0196596851496 | 1.0 | USP39 TUT1 CENATAC SNRPG DDX23 | RNA processing |
| GO:0000377 | 0.0264444778619 | 0.8 | USP39 CENATAC SNRPG DDX23 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000398 | 0.0264444778619 | 0.8 | USP39 CENATAC SNRPG DDX23 | mRNA splicing, via spliceosome |
| GO:0000375 | 0.0280745884658 | 0.8 | USP39 CENATAC SNRPG DDX23 | RNA splicing, via transesterification reactions |
| CORUM:1181 | 0.0395319616948 | 0.4 | DDX23 SNRPG | C complex spliceosome |
| GO:0097525 | 0.039797089625 | 0.6 | USP39 SNRPG DDX23 | spliceosomal snRNP complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| DDX23 | SNRPG | 0.999 | 0.802 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM |
| DDX23 | TUT1 | 0.999 | 0.154 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| DDX23 | USP39 | 0.998 | 0.876 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM |
| USP39 | TUT1 | 0.998 | 0.188 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| USP39 | SNRPG | 0.998 | 0.708 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM |
| TUT1 | SNRPG | 0.996 | 0.116 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| SNRPG | CENATAC | 0.992 | 0.166 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TUT1 | CENATAC | 0.972 | 0.098 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| USP39 | CENATAC | 0.957 | 0.262 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| DDX23 | CENATAC | 0.902 | 0.124 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes