List of Gene Names or Uniprot ACCs (ex. OFD1 PCM1 Q1MSJ5):

Enrichment (ex. cilium):

Protein (ex. Centrosomal protein):

Complex: huMAP3_01886.1

Confidence: Extremely High   ?

Proteins

Genename	Protein Name	Uniprot Annotation Score	Links
BMAL2	Basic helix-loop-helix ARNT-like protein 2 (Aryl hydrocarbon receptor nuclear translocator-like protein 2) (Basic-helix-loop-helix-PAS protein MOP9) (Brain and muscle ARNT-like 2) (CYCLE-like factor) (CLIF) (Class E basic helix-loop-helix protein 6) (bHLHe6) (Member of PAS protein 9) (PAS domain-containing protein 9)	5	UniProt   NCBI
PDE6B	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta (GMP-PDE beta) (EC 3.1.4.35)	5	UniProt   NCBI
CIPC	CLOCK-interacting pacemaker (CLOCK-interacting circadian protein)	5	UniProt   NCBI
NPAS2	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Basic-helix-loop-helix-PAS protein MOP4) (Class E basic helix-loop-helix protein 9) (bHLHe9) (Member of PAS protein 4) (PAS domain-containing protein 4)	5	UniProt   NCBI
CLOCK	Circadian locomoter output cycles protein kaput (hCLOCK) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 8) (bHLHe8)	5	UniProt   NCBI
BMAL1	Basic helix-loop-helix ARNT-like protein 1 (Aryl hydrocarbon receptor nuclear translocator-like protein 1) (Basic-helix-loop-helix-PAS protein MOP3) (Brain and muscle ARNT-like 1) (Class E basic helix-loop-helix protein 5) (bHLHe5) (Member of PAS protein 3) (PAS domain-containing protein 3) (bHLH-PAS protein JAP3)	5	UniProt   NCBI



Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:1990513	3.94689465137e-10	0.666666666667	CLOCK BMAL2 BMAL1 NPAS2	CLOCK-BMAL transcription complex
REAC:R-HSA-1368108	1.28224530028e-08	0.666666666667	CLOCK BMAL2 BMAL1 NPAS2	BMAL1:CLOCK,NPAS2 activates circadian gene expression
GO:0007623	2.42111187139e-08	1.0	CLOCK BMAL2 BMAL1 PDE6B CIPC NPAS2	circadian rhythm
GO:0048511	5.2868904657e-08	1.0	CLOCK BMAL2 BMAL1 PDE6B CIPC NPAS2	rhythmic process
WP:WP3594	6.10618638351e-08	0.833333333333	CLOCK BMAL1 BMAL2 NPAS2 CIPC	Circadian rhythm genes
REAC:R-HSA-400253	7.52526034648e-07	0.666666666667	CLOCK BMAL2 BMAL1 NPAS2	Circadian Clock
GO:0042752	1.46765266271e-06	0.833333333333	PDE6B BMAL1 BMAL2 CLOCK CIPC	regulation of circadian rhythm
KEGG:04710	8.04611191878e-06	0.5	CLOCK NPAS2 BMAL1	Circadian rhythm
CORUM:7272	1.70876175213e-05	0.333333333333	CLOCK BMAL1	Core clock complex
CORUM:7271	1.70876175213e-05	0.333333333333	BMAL1 NPAS2	ARNTL-NPAS2 complex
CORUM:7311	5.12534978153e-05	0.333333333333	CLOCK BMAL1	CRY1-Core clock complex
REAC:R-HSA-9707616	8.06503831344e-05	0.5	CLOCK NPAS2 BMAL1	Heme signaling
GO:0051775	0.00010757157937	0.5	CLOCK NPAS2 BMAL1	response to redox state
WP:WP5205	0.000136846667216	0.5	CLOCK NPAS2 BMAL1	Clock controlled autophagy in bone metabolism
GO:0032922	0.000178553196738	0.666666666667	CLOCK BMAL2 BMAL1 NPAS2	circadian regulation of gene expression
GO:0042753	0.0002304395259	0.5	CLOCK BMAL2 BMAL1	positive regulation of circadian rhythm
REAC:R-HSA-1989781	0.00109225187932	0.5	CLOCK NPAS2 BMAL1	PPARA activates gene expression
REAC:R-HSA-400206	0.00112585873244	0.5	CLOCK NPAS2 BMAL1	Regulation of lipid metabolism by PPARalpha
WP:WP3298	0.00352059040085	0.333333333333	CLOCK BMAL1	Melatonin metabolism and effects
WP:WP410	0.00820373460581	0.333333333333	CLOCK BMAL1	Exercise induced circadian regulation
WP:WP5348	0.00989727276085	0.333333333333	CLOCK BMAL1	11p11 2 copy number variation syndrome
WP:WP5352	0.0108030732892	0.333333333333	CLOCK BMAL1	10q11 21q11 23 copy number variation syndrome
WP:WP5130	0.0159206501541	0.333333333333	CLOCK BMAL1	Th17 cell differentiation pathway
GO:0070888	0.0161301339283	0.5	CLOCK BMAL2 BMAL1	E-box binding
GO:0090575	0.0275845262239	0.666666666667	CLOCK BMAL2 BMAL1 NPAS2	RNA polymerase II transcription regulator complex
KEGG:04728	0.0419636118509	0.333333333333	CLOCK BMAL1	Dopaminergic synapse
CORUM:7274	0.0499436884912	0.166666666667	BMAL1	ARNTL-EPAS1 complex



Edges

Protein 1	Protein 2	Score ?	ProteomeHD?	Evidence ?
NPAS2	BMAL1	0.999		bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
BMAL2	NPAS2	0.999		bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
BMAL2	CLOCK	0.999		bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
CLOCK	BMAL1	0.998	0.174	hein_WMM     bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     boldt     bioplex3_HCT116     boldt_WMM
CIPC	NPAS2	0.997		bioplex3_HEK293     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116     WMM_only
NPAS2	CLOCK	0.997		bioplex3_HEK293     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116     WMM_only
CIPC	CLOCK	0.997		bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
BMAL2	BMAL1	0.997		bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM
PDE6B	CLOCK	0.996		bioplex3_HEK293     bioplex3_WMM     bioplex3_HCT116     WMM_only
BMAL2	CIPC	0.986		bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
CIPC	BMAL1	0.965		bioplex3_WMM     bioplex3_HCT116     WMM_only
PDE6B	BMAL1	0.905		bioplex3_WMM     WMM_only
PDE6B	NPAS2	0.795		bioplex3_WMM     WMM_only





Related Complexes

Genename	Complexes
BMAL2	huMAP3_01886.1 huMAP3_12955.1 huMAP3_15323.1
PDE6B	huMAP3_01886.1 huMAP3_12955.1 huMAP3_15323.1
CIPC	huMAP3_01886.1 huMAP3_12955.1 huMAP3_15323.1
NPAS2	huMAP3_01886.1 huMAP3_12955.1 huMAP3_15323.1
CLOCK	huMAP3_01886.1 huMAP3_12955.1 huMAP3_15323.1
BMAL1	huMAP3_01886.1 huMAP3_12955.1 huMAP3_15323.1