hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_01890.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| STRADB | STE20-related kinase adapter protein beta (STRAD beta) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (CALS-21) (ILP-interacting protein) (Pseudokinase ALS2CR2) | 5 | UniProt NCBI |
| STK11 | Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1) (LKB1) (hLKB1) (Renal carcinoma antigen NY-REN-19) | 5 | UniProt NCBI |
| STRADA | STE20-related kinase adapter protein alpha (STRAD alpha) (STE20-related adapter protein) (Serologically defined breast cancer antigen NY-BR-96) | 5 | UniProt NCBI |
| CAB39 | Calcium-binding protein 39 (MO25alpha) (Protein Mo25) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6053 | 7.01606139244e-10 | 0.75 | STK11 STRADA CAB39 | LKB1-STRAD-MO25 complex |
| REAC:R-HSA-380972 | 2.28084415729e-09 | 1.0 | STRADB STRADA CAB39 STK11 | Energy dependent regulation of mTOR by LKB1-AMPK |
| REAC:R-HSA-165159 | 9.72511000838e-09 | 1.0 | STRADB STRADA CAB39 STK11 | MTOR signalling |
| WP:WP1403 | 1.24830709593e-08 | 1.0 | STRADB STRADA CAB39 STK11 | AMP activated protein kinase signaling |
| KEGG:04152 | 1.51268026593e-07 | 1.0 | STRADB STRADA CAB39 STK11 | AMPK signaling pathway |
| KEGG:04150 | 4.50852953757e-07 | 1.0 | STRADB STRADA CAB39 STK11 | mTOR signaling pathway |
| WP:WP3595 | 3.82933516227e-05 | 0.5 | STRADB STK11 | mir 124 predicted interactions with cell cycle and differentiation |
| GO:0030295 | 6.72337716283e-05 | 1.0 | STRADB STRADA CAB39 STK11 | protein kinase activator activity |
| GO:0019209 | 8.0240394575e-05 | 1.0 | STRADB STRADA CAB39 STK11 | kinase activator activity |
| GO:1902554 | 0.00026336641285 | 1.0 | STRADB STRADA CAB39 STK11 | serine/threonine protein kinase complex |
| GO:1902911 | 0.000439465274636 | 1.0 | STRADB STRADA CAB39 STK11 | protein kinase complex |
| WP:WP3932 | 0.000866797679386 | 0.75 | STK11 STRADA CAB39 | Focal adhesion PI3K Akt mTOR signaling pathway |
| GO:0019887 | 0.00097067298424 | 1.0 | STRADB STRADA CAB39 STK11 | protein kinase regulator activity |
| GO:0045860 | 0.00153690814718 | 1.0 | STRADB STRADA CAB39 STK11 | positive regulation of protein kinase activity |
| GO:0019207 | 0.0018072843765 | 1.0 | STRADB STRADA CAB39 STK11 | kinase regulator activity |
| GO:0033674 | 0.00215246912609 | 1.0 | STRADB STRADA CAB39 STK11 | positive regulation of kinase activity |
| GO:0043539 | 0.00508133939815 | 0.75 | STRADB STRADA CAB39 | protein serine/threonine kinase activator activity |
| GO:0061695 | 0.00622455085576 | 1.0 | STRADB STRADA CAB39 STK11 | transferase complex, transferring phosphorus-containing groups |
| GO:0051347 | 0.00659538015866 | 1.0 | STRADB STRADA CAB39 STK11 | positive regulation of transferase activity |
| GO:0032147 | 0.0152210712647 | 0.75 | STRADB STRADA STK11 | activation of protein kinase activity |
| GO:0045859 | 0.0158036333889 | 1.0 | STRADB STRADA CAB39 STK11 | regulation of protein kinase activity |
| GO:0043549 | 0.0217964165388 | 1.0 | STRADB STRADA CAB39 STK11 | regulation of kinase activity |
| GO:0008047 | 0.0270968554266 | 1.0 | STRADB STRADA CAB39 STK11 | enzyme activator activity |
| GO:0001934 | 0.0270968554266 | 1.0 | STRADB STRADA CAB39 STK11 | positive regulation of protein phosphorylation |
| GO:0042327 | 0.0333098536164 | 1.0 | STRADB STRADA CAB39 STK11 | positive regulation of phosphorylation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| STRADB | CAB39 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| STK11 | STRADB | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| STK11 | CAB39 | 0.999 | 0.104666666667 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| STK11 | STRADA | 0.999 | 0.22 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CAB39 | STRADA | 0.996 | 0.08 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| STRADB | STRADA | 0.842 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes