hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_01901.1

Complex Portal: CPX-11794

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
CDK9	Cyclin-dependent kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (C-2K) (Cell division cycle 2-like protein kinase 4) (Cell division protein kinase 9) (Serine/threonine-protein kinase PITALRE) (Tat-associated kinase complex catalytic subunit)	5	UniProt NCBI
CCNT2	Cyclin-T2 (CycT2)	5	UniProt NCBI
AFF1	AF4/FMR2 family member 1 (ALL1-fused gene from chromosome 4 protein) (Protein AF-4) (Protein FEL) (Proto-oncogene AF4)	5	UniProt NCBI
CCNT1	Cyclin-T1 (CycT1) (Cyclin-T)	5	UniProt NCBI
MLLT3	Protein AF-9 (ALL1-fused gene from chromosome 9 protein) (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein) (YEATS domain-containing protein 3)	5	UniProt NCBI
EAF2	ELL-associated factor 2 (Testosterone-regulated apoptosis inducer and tumor suppressor protein)	5	UniProt NCBI
AFF4	AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein)	5	UniProt NCBI
ELL2	RNA polymerase II elongation factor ELL2	5	UniProt NCBI
MLLT1	Protein ENL (YEATS domain-containing protein 1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:6084	2.33882970105e-24	0.888888888889	AFF4 AFF1 MLLT3 CCNT1 CCNT2 CDK9 ELL2 MLLT1	AFF4 super elongation complex (SEC)
GO:0008023	8.14699930962e-19	1.0	AFF4 AFF1 MLLT3 CCNT1 CCNT2 CDK9 ELL2 EAF2 MLLT1	transcription elongation factor complex
KEGG:03250	1.69500908875e-14	0.777777777778	AFF4 MLLT3 CCNT1 CCNT2 CDK9 ELL2 MLLT1	Viral life cycle - HIV-1
REAC:R-HSA-75955	7.94485302737e-14	0.777777777778	AFF4 MLLT3 CCNT1 CCNT2 CDK9 EAF2 MLLT1	RNA Polymerase II Transcription Elongation
REAC:R-HSA-112382	7.94485302737e-14	0.777777777778	AFF4 MLLT3 CCNT1 CCNT2 CDK9 EAF2 MLLT1	Formation of RNA Pol II elongation complex
REAC:R-HSA-674695	8.68780838858e-13	0.777777777778	AFF4 MLLT3 CCNT1 CCNT2 CDK9 EAF2 MLLT1	RNA Polymerase II Pre-transcription Events
KEGG:05202	5.3422331801e-09	0.666666666667	AFF1 MLLT3 CCNT1 CCNT2 MLLT1 CDK9	Transcriptional misregulation in cancer
REAC:R-HSA-73857	2.73537046558e-06	0.888888888889	AFF4 MLLT3 CCNT1 CCNT2 CDK9 ELL2 EAF2 MLLT1	RNA Polymerase II Transcription
GO:0140513	3.94888258364e-06	1.0	AFF4 AFF1 MLLT3 CCNT1 CCNT2 CDK9 ELL2 EAF2 MLLT1	nuclear protein-containing complex
REAC:R-HSA-74160	7.41346360783e-06	0.888888888889	AFF4 MLLT3 CCNT1 CCNT2 CDK9 ELL2 EAF2 MLLT1	Gene expression (Transcription)
REAC:R-HSA-6807505	1.58664855984e-05	0.444444444444	CCNT2 ELL2 CDK9 CCNT1	RNA polymerase II transcribes snRNA genes
GO:0034243	2.35552553862e-05	0.555555555556	CCNT2 EAF2 ELL2 CDK9 CCNT1	regulation of transcription elongation by RNA polymerase II
CORUM:1080	2.73623797451e-05	0.222222222222	CCNT2 CDK9	P-TEFb.2 complex
CORUM:1082	2.73623797451e-05	0.222222222222	CDK9 CCNT1	P-TEFb.1 complex
CORUM:1079	2.73623797451e-05	0.222222222222	CDK9 CCNT1	P-TEFb.1 complex
GO:0032784	6.43973122888e-05	0.555555555556	CCNT2 EAF2 ELL2 CDK9 CCNT1	regulation of DNA-templated transcription elongation
GO:0006368	7.94206923087e-05	0.555555555556	CCNT2 EAF2 ELL2 CDK9 CCNT1	transcription elongation by RNA polymerase II
REAC:R-HSA-176034	7.98825873128e-05	0.222222222222	CDK9 CCNT1	Interactions of Tat with host cellular proteins
CORUM:2875	8.20609246787e-05	0.222222222222	CDK9 CCNT1	BRD4-P-TEFb complex
CORUM:2873	8.20609246787e-05	0.222222222222	CDK9 CCNT1	P-TEFb-7SKRNA-HEXIM1 complex
CORUM:2878	8.20609246787e-05	0.222222222222	CDK9 CCNT1	P-TEFb-7SKRNA-HEXIM1 complex
CORUM:2605	8.20609246787e-05	0.222222222222	CDK9 CCNT1	CCNT1- CDK9-GRN complex
CORUM:2602	8.20609246787e-05	0.222222222222	CDK9 CCNT1	P-TEFb-7SKRNA-HEXIM1 complex
CORUM:2603	8.20609246787e-05	0.222222222222	CDK9 CCNT1	Transcription elongation factor complex (SUPT5H, CDK9, CCNT1)
CORUM:2877	8.20609246787e-05	0.222222222222	CDK9 CCNT1	BRD4-P-TEFb complex
CORUM:2604	8.20609246787e-05	0.222222222222	CDK9 CCNT1	P-TEFb-SKP2 complex
CORUM:1457	8.20609246787e-05	0.222222222222	AFF1 MLLT1	AFF1-MLLT1-CBX8 complex
CORUM:2599	0.000164069436391	0.222222222222	CDK9 CCNT1	POLR2A-CCNT1-CDK9-NCL-LEM6-CPSF2 complex
CORUM:2601	0.000164069436391	0.222222222222	CDK9 CCNT1	P-TEFb-BRD4-TRAP220 complex
CORUM:7566	0.000164069436391	0.222222222222	CDK9 CCNT1	7SK RNP complex
GO:0006354	0.000177406412228	0.555555555556	CCNT2 EAF2 ELL2 CDK9 CCNT1	DNA-templated transcription elongation
REAC:R-HSA-167290	0.000188109751173	0.333333333333	CCNT2 CDK9 CCNT1	Pausing and recovery of HIV elongation
REAC:R-HSA-167287	0.000188109751173	0.333333333333	CCNT2 CDK9 CCNT1	HIV elongation arrest and recovery
REAC:R-HSA-2173796	0.000270453254448	0.333333333333	CCNT2 CDK9 CCNT1	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
GO:0097322	0.00045145282213	0.333333333333	CCNT2 CDK9 CCNT1	7SK snRNA binding
GO:0008024	0.00045145282213	0.333333333333	CCNT2 CDK9 CCNT1	cyclin/CDK positive transcription elongation factor complex
REAC:R-HSA-167152	0.000500428099492	0.333333333333	CCNT2 CDK9 CCNT1	Formation of HIV elongation complex in the absence of HIV Tat
GO:0032968	0.000584421737577	0.444444444444	CCNT2 ELL2 CDK9 CCNT1	positive regulation of transcription elongation by RNA polymerase II
REAC:R-HSA-2173793	0.000739221826765	0.333333333333	CCNT2 CDK9 CCNT1	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
CORUM:2600	0.000764679747525	0.222222222222	CDK9 CCNT1	BRD4 complex
REAC:R-HSA-6796648	0.00135277785859	0.333333333333	CCNT2 CDK9 CCNT1	TP53 Regulates Transcription of DNA Repair Genes
GO:0032786	0.00138595187942	0.444444444444	CCNT2 ELL2 CDK9 CCNT1	positive regulation of DNA-templated transcription, elongation
CORUM:2639	0.00180015784734	0.222222222222	CDK9 CCNT1	HES1 promoter-Notch enhancer complex
REAC:R-HSA-167172	0.00187967474963	0.333333333333	CCNT2 CDK9 CCNT1	Transcription of the HIV genome
WP:WP4673	0.00379554307103	0.333333333333	CCNT2 CDK9 CCNT1	Male infertility
REAC:R-HSA-170834	0.00395224313584	0.333333333333	CCNT2 CDK9 CCNT1	Signaling by TGF-beta Receptor Complex
GO:0019908	0.00546674693619	0.333333333333	CCNT2 CDK9 CCNT1	nuclear cyclin-dependent protein kinase holoenzyme complex
GO:0043923	0.00655807506899	0.333333333333	CCNT2 CDK9 CCNT1	positive regulation by host of viral transcription
REAC:R-HSA-9006936	0.00756314206499	0.333333333333	CCNT2 CDK9 CCNT1	Signaling by TGFB family members
GO:0032806	0.00915637133828	0.333333333333	CCNT2 CDK9 CCNT1	carboxy-terminal domain protein kinase complex
WP:WP3414	0.012380386891	0.222222222222	CDK9 CCNT1	Initiation of transcription and translation elongation at the HIV 1 LTR
REAC:R-HSA-162599	0.0131636816219	0.333333333333	CCNT2 CDK9 CCNT1	Late Phase of HIV Life Cycle
GO:0045893	0.0154442953573	0.777777777778	MLLT3 CCNT1 CCNT2 CDK9 ELL2 EAF2 MLLT1	positive regulation of DNA-templated transcription
GO:1902680	0.0157504090511	0.777777777778	MLLT3 CCNT1 CCNT2 CDK9 ELL2 EAF2 MLLT1	positive regulation of RNA biosynthetic process
GO:0070691	0.016855225923	0.222222222222	CDK9 CCNT1	P-TEFb complex
REAC:R-HSA-162587	0.0171260552969	0.333333333333	CCNT2 CDK9 CCNT1	HIV Life Cycle
GO:0051254	0.0338404915513	0.777777777778	MLLT3 CCNT1 CCNT2 CDK9 ELL2 EAF2 MLLT1	positive regulation of RNA metabolic process
REAC:R-HSA-167238	0.0344394959621	0.222222222222	CDK9 CCNT1	Pausing and recovery of Tat-mediated HIV elongation
REAC:R-HSA-167243	0.0344394959621	0.222222222222	CDK9 CCNT1	Tat-mediated HIV elongation arrest and recovery

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
AFF4	MLLT1	1.0	0.298		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () Malo bioplex3_HCT116 fraction
CDK9	CCNT1	1.0	0.562	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM
CDK9	CCNT2	1.0	0.262	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM Malo bioplex3_HCT116 fraction
AFF1	MLLT1	1.0	0.168		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
AFF1	AFF4	0.999	0.134		hein_WMM bioplex_WMM bioplex3_WMM hein ()
MLLT3	AFF1	0.999	0.22		hein_WMM bioplex_WMM bioplex3_WMM hein ()
CCNT2	CCNT1	0.999	0.112	mutually_exclusive (P50750)	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
AFF4	ELL2	0.999	0.076		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
MLLT3	MLLT1	0.999	0.326		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein ()
CCNT1	AFF4	0.998	0.134		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
MLLT3	AFF4	0.998	0.2		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
CDK9	AFF1	0.998	0.112	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
ELL2	MLLT1	0.998	0.082		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein ()
AFF1	ELL2	0.997	0.08		hein_WMM bioplex_WMM bioplex3_WMM hein ()
CCNT2	AFF4	0.997	0.196		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116
EAF2	AFF4	0.997			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
CDK9	AFF4	0.997	0.064	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
CCNT1	MLLT1	0.996	0.196933333333		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM
MLLT3	ELL2	0.995	0.054		hein_WMM bioplex_WMM bioplex3_WMM hein ()
CCNT2	MLLT1	0.994	0.204		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein ()
CDK9	MLLT1	0.994	0.29	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM
MLLT3	CCNT1	0.989	0.202349206349		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
CDK9	ELL2	0.989	0.098		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
AFF1	EAF2	0.987			bioplex_WMM bioplex3_WMM WMM_only
EAF2	MLLT1	0.984			bioplex_WMM bioplex3_WMM WMM_only
AFF1	CCNT1	0.98	0.172		hein_WMM bioplex_WMM bioplex3_WMM hein ()
CCNT1	ELL2	0.976	0.084		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
CCNT2	AFF1	0.974	0.160571428571		hein_WMM bioplex_WMM bioplex3_WMM hein ()
MLLT3	CCNT2	0.964	0.112		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
CCNT2	ELL2	0.963	0.116		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
MLLT3	CDK9	0.958	0.206	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM
CCNT1	EAF2	0.912			bioplex_WMM bioplex3_WMM WMM_only
EAF2	ELL2	0.843			bioplex_WMM bioplex3_WMM WMM_only
CDK9	EAF2	0.68			bioplex_WMM bioplex3_WMM WMM_only
MLLT3	EAF2	0.654			bioplex_WMM bioplex3_WMM WMM_only
CCNT2	EAF2	0.4			bioplex_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
CDK9	huMAP3_01901.1 huMAP3_06690.1 huMAP3_12350.1 huMAP3_13608.1 huMAP3_13960.1 huMAP3_14693.1
CCNT2	huMAP3_01901.1 huMAP3_06690.1 huMAP3_12350.1 huMAP3_13608.1 huMAP3_13960.1 huMAP3_14693.1
AFF1	huMAP3_01901.1 huMAP3_06690.1 huMAP3_12350.1 huMAP3_13608.1 huMAP3_13960.1 huMAP3_14693.1
CCNT1	huMAP3_01901.1 huMAP3_06690.1 huMAP3_12350.1 huMAP3_13608.1 huMAP3_13960.1 huMAP3_14693.1
MLLT3	huMAP3_01817.1 huMAP3_01901.1 huMAP3_05877.1 huMAP3_06690.1 huMAP3_09651.1 huMAP3_11645.1 huMAP3_12350.1 huMAP3_13608.1 huMAP3_13960.1 huMAP3_14693.1 huMAP3_15049.1
EAF2	huMAP3_01901.1 huMAP3_06690.1 huMAP3_12350.1 huMAP3_13608.1 huMAP3_13960.1 huMAP3_14693.1
AFF4	huMAP3_01901.1 huMAP3_06690.1 huMAP3_12350.1 huMAP3_13608.1 huMAP3_13960.1 huMAP3_14693.1
ELL2	huMAP3_01901.1 huMAP3_06690.1 huMAP3_12350.1 huMAP3_13608.1 huMAP3_13960.1 huMAP3_14693.1
MLLT1	huMAP3_01901.1 huMAP3_06690.1 huMAP3_12350.1 huMAP3_13608.1 huMAP3_13960.1 huMAP3_14693.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_01901.1

Complex Portal: CPX-11794