hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01906.1
Complex Portal: CPX-6241
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| VPS33B | Vacuolar protein sorting-associated protein 33B (hVPS33B) | 5 | UniProt NCBI |
| VIPAS39 | Spermatogenesis-defective protein 39 homolog (hSPE-39) (VPS33B-interacting protein in apical-basolateral polarity regulator) (VPS33B-interacting protein in polarity and apical restriction) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6390 | 1.70876175213e-06 | 1.0 | VPS33B VIPAS39 | Endosomal targeting complex (VIPAS39-VPS33B) |
| HP:0200084 | 2.05051410255e-05 | 1.0 | VPS33B VIPAS39 | Giant cell hepatitis |
| HP:0009806 | 5.12628525639e-05 | 1.0 | VPS33B VIPAS39 | Nephrogenic diabetes insipidus |
| HP:0001884 | 0.000153788557692 | 1.0 | VPS33B VIPAS39 | Talipes calcaneovalgus |
| HP:0002611 | 0.000410102820511 | 1.0 | VPS33B VIPAS39 | Cholestatic liver disease |
| HP:0002908 | 0.00102525705128 | 1.0 | VPS33B VIPAS39 | Conjugated hyperbilirubinemia |
| HP:0001667 | 0.00102525705128 | 1.0 | VPS33B VIPAS39 | Right ventricular hypertrophy |
| HP:0001947 | 0.00227607065384 | 1.0 | VPS33B VIPAS39 | Renal tubular acidosis |
| HP:0000873 | 0.00489047613459 | 1.0 | VPS33B VIPAS39 | Diabetes insipidus |
| HP:0001707 | 0.0054543675128 | 1.0 | VPS33B VIPAS39 | Abnormal right ventricle morphology |
| HP:0012115 | 0.0077851185427 | 1.0 | VPS33B VIPAS39 | Hepatitis |
| HP:0000121 | 0.00948362772432 | 1.0 | VPS33B VIPAS39 | Nephrocalcinosis |
| HP:0000112 | 0.0113495955576 | 1.0 | VPS33B VIPAS39 | Nephropathy |
| GO:0017185 | 0.0131096201623 | 1.0 | VPS33B VIPAS39 | peptidyl-lysine hydroxylation |
| HP:0000124 | 0.0152592424465 | 1.0 | VPS33B VIPAS39 | Renal tubular dysfunction |
| HP:0002904 | 0.0159119894358 | 1.0 | VPS33B VIPAS39 | Hyperbilirubinemia |
| HP:0033479 | 0.0162434892157 | 1.0 | VPS33B VIPAS39 | Abnormal circulating bilirubin concentration |
| HP:0003355 | 0.0186596783332 | 1.0 | VPS33B VIPAS39 | Aminoaciduria |
| HP:0000989 | 0.020488053408 | 1.0 | VPS33B VIPAS39 | Pruritus |
| HP:0002804 | 0.0208639809935 | 1.0 | VPS33B VIPAS39 | Arthrogryposis multiplex congenita |
| GO:0090385 | 0.0210690324038 | 1.0 | VPS33B VIPAS39 | phagosome-lysosome fusion |
| HP:0010995 | 0.0252247409849 | 1.0 | VPS33B VIPAS39 | Abnormal circulating dicarboxylic acid concentration |
| HP:0008064 | 0.0252247409849 | 1.0 | VPS33B VIPAS39 | Ichthyosis |
| GO:0001845 | 0.0309012475255 | 1.0 | VPS33B VIPAS39 | phagolysosome assembly |
| HP:0002803 | 0.0318376489657 | 1.0 | VPS33B VIPAS39 | Congenital contracture |
| HP:0001714 | 0.0318376489657 | 1.0 | VPS33B VIPAS39 | Ventricular hypertrophy |
| HP:0001942 | 0.0332525036964 | 1.0 | VPS33B VIPAS39 | Metabolic acidosis |
| HP:0001385 | 0.0351868219998 | 1.0 | VPS33B VIPAS39 | Hip dysplasia |
| HP:0000340 | 0.0473702932925 | 1.0 | VPS33B VIPAS39 | Sloping forehead |
| HP:0001339 | 0.0479410197177 | 1.0 | VPS33B VIPAS39 | Lissencephaly |
| HP:0034714 | 0.0499436884913 | 0.5 | VPS33B | Hepatic melanin-like lysosomal pigmentation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| VPS33B | VIPAS39 | 0.957 | 0.774 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes