hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01912.1
Complex Portal: CPX-18123
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UBN2 | Ubinuclein-2 | 3 | UniProt NCBI |
| CABIN1 | Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) | 5 | UniProt NCBI |
| HIRA | Protein HIRA (TUP1-like enhancer of split protein 1) | 5 | UniProt NCBI |
| UBN1 | Ubinuclein-1 (HIRA-binding protein) (Protein VT4) (Ubiquitously expressed nuclear protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7382 | 2.80628050973e-09 | 0.75 | CABIN1 HIRA UBN1 | Prohibitin-HIRA complex |
| CORUM:7383 | 2.80628050973e-09 | 0.75 | CABIN1 HIRA UBN1 | OGT-HIRA complex |
| REAC:R-HSA-2559584 | 6.38068337719e-07 | 0.75 | CABIN1 HIRA UBN1 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) |
| REAC:R-HSA-2559586 | 6.70000655285e-05 | 0.75 | CABIN1 HIRA UBN1 | DNA Damage/Telomere Stress Induced Senescence |
| REAC:R-HSA-2559583 | 0.00122110889015 | 0.75 | CABIN1 HIRA UBN1 | Cellular Senescence |
| GO:0006334 | 0.0326725154884 | 0.75 | CABIN1 HIRA UBN1 | nucleosome assembly |
| CORUM:5189 | 0.049938562206 | 0.25 | CABIN1 | YWHAQ-CALM1-CABIN1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CABIN1 | HIRA | 0.999 | 0.252 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| UBN2 | HIRA | 0.998 | 0.266 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| CABIN1 | UBN2 | 0.997 | 0.174 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| HIRA | UBN1 | 0.975 | 0.404 |
mutually_exclusive (Q9Y294)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| UBN2 | UBN1 | 0.972 | 0.094 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| CABIN1 | UBN1 | 0.884 | 0.124 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes