hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_01916.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CASP5 | Caspase-5 (CASP-5) (EC 3.4.22.58) (ICE(rel)-III) (Protease ICH-3) (Protease TY) [Cleaved into: Caspase-5 subunit p20; Caspase-5 subunit p10] | 5 | UniProt NCBI |
| CASP4 | Caspase-4 (CASP-4) (EC 3.4.22.57) (ICE and Ced-3 homolog 2) (ICH-2) (ICE(rel)-II) (Mih1) (Protease TX) [Cleaved into: Caspase-4 subunit p10; Caspase-4 subunit p20] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5620971 | 0.000432316723289 | 1.0 | CASP5 CASP4 | Pyroptosis |
| KEGG:04621 | 0.001720800216 | 1.0 | CASP5 CASP4 | NOD-like receptor signaling pathway |
| WP:WP5322 | 0.00206476517557 | 1.0 | CASP5 CASP4 | CKAP4 signaling pathway map |
| REAC:R-HSA-5218859 | 0.00235467369443 | 1.0 | CASP5 CASP4 | Regulated Necrosis |
| KEGG:05132 | 0.00406034068917 | 1.0 | CASP5 CASP4 | Salmonella infection |
| GO:0097200 | 0.00702301080125 | 1.0 | CASP5 CASP4 | cysteine-type endopeptidase activity involved in execution phase of apoptosis |
| GO:0097153 | 0.016855225923 | 1.0 | CASP5 CASP4 | cysteine-type endopeptidase activity involved in apoptotic process |
| REAC:R-HSA-5357801 | 0.0319897287616 | 1.0 | CASP5 CASP4 | Programmed Cell Death |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CASP5 | CASP4 | 0.997 | bioplex3_HEK293 bioplex () bioplex3_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| CASP5 | huMAP3_01916.1 huMAP3_11721.1 huMAP3_12657.1 huMAP3_13067.1 |
| CASP4 | huMAP3_01916.1 huMAP3_12657.1 huMAP3_13067.1 |