hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_01937.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CTSL | Procathepsin L (EC 3.4.22.15) (Cathepsin L1) (Major excreted protein) (MEP) [Cleaved into: Cathepsin L; Cathepsin L heavy chain; Cathepsin L light chain] | 5 | UniProt NCBI |
| CTSB | Cathepsin B (EC 3.4.22.1) (APP secretase) (APPS) (Cathepsin B1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain] | 5 | UniProt NCBI |
| CST3 | Cystatin-C (Cystatin-3) (Gamma-trace) (Neuroendocrine basic polypeptide) (Post-gamma-globulin) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0030574 | 0.000281151120149 | 1.0 | CTSL CST3 CTSB | collagen catabolic process |
| HPA:0271143 | 0.0003702024987 | 1.0 | CTSL CST3 CTSB | kidney; proximal tubules (cell body)[High] |
| REAC:R-HSA-1679131 | 0.000374861161166 | 0.666666666667 | CTSL CTSB | Trafficking and processing of endosomal TLR |
| KEGG:04612 | 0.00139320827864 | 0.666666666667 | CTSL CTSB | Antigen processing and presentation |
| GO:0032963 | 0.00238416149886 | 1.0 | CTSL CST3 CTSB | collagen metabolic process |
| HPA:0271142 | 0.00270890319003 | 1.0 | CTSL CST3 CTSB | kidney; proximal tubules (cell body)[>=Medium] |
| GO:0060309 | 0.00421361424067 | 0.666666666667 | CTSL CST3 | elastin catabolic process |
| KEGG:04210 | 0.00542112539104 | 0.666666666667 | CTSL CTSB | Apoptosis |
| HPA:0271141 | 0.00559675276927 | 1.0 | CTSL CST3 CTSB | kidney; proximal tubules (cell body)[>=Low] |
| KEGG:04142 | 0.00569595332742 | 0.666666666667 | CTSL CTSB | Lysosome |
| REAC:R-HSA-2022090 | 0.00735562020533 | 0.666666666667 | CTSL CTSB | Assembly of collagen fibrils and other multimeric structures |
| WP:WP4217 | 0.00751610583681 | 0.666666666667 | CTSL CTSB | Ebola virus infection in host |
| REAC:R-HSA-1442490 | 0.00800131218049 | 0.666666666667 | CTSL CTSB | Collagen degradation |
| KEGG:04140 | 0.00916431091176 | 0.666666666667 | CTSL CTSB | Autophagy - animal |
| GO:0036021 | 0.0140440992017 | 0.666666666667 | CTSL CTSB | endolysosome lumen |
| GO:0051541 | 0.0140440992017 | 0.666666666667 | CTSL CST3 | elastin metabolic process |
| WP:WP5115 | 0.0163374881119 | 0.666666666667 | CTSL CTSB | Network map of SARS CoV 2 signaling pathway |
| REAC:R-HSA-1474290 | 0.017372320015 | 0.666666666667 | CTSL CTSB | Collagen formation |
| GO:0097067 | 0.0294899169624 | 0.666666666667 | CTSL CTSB | cellular response to thyroid hormone stimulus |
| REAC:R-HSA-1474228 | 0.037053837229 | 0.666666666667 | CTSL CTSB | Degradation of the extracellular matrix |
| GO:0097066 | 0.0393180950424 | 0.666666666667 | CTSL CTSB | response to thyroid hormone |
| WP:WP3890 | 0.0413734636003 | 0.333333333333 | CTSB | Nanomaterial induced inflammasome activation |
| REAC:R-HSA-2132295 | 0.0460272953732 | 0.666666666667 | CTSL CTSB | MHC class II antigen presentation |
| WP:WP4846 | 0.0496447587094 | 0.333333333333 | CTSL | SARS CoV 2 and COVID 19 pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CTSL | CST3 | 0.998 | 0.104 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 fraction |
| CTSB | CST3 | 0.994 | 0.330580645161 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| CTSL | CTSB | 0.726 | 0.172424242424 | Guru bioplex3_WMM fraction |
Related Complexes