hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01951.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DCAF5 | DDB1- and CUL4-associated factor 5 (Breakpoint cluster region protein 2) (BCRP2) (WD repeat-containing protein 22) | 5 | UniProt NCBI |
| DCAF13 | DDB1- and CUL4-associated factor 13 (WD repeat and SOF domain-containing protein 1) | 5 | UniProt NCBI |
| FBXW8 | F-box/WD repeat-containing protein 8 (F-box and WD-40 domain-containing protein 8) (F-box only protein 29) | 5 | UniProt NCBI |
| CCT5 | T-complex protein 1 subunit epsilon (TCP-1-epsilon) (CCT-epsilon) | 5 | UniProt NCBI |
| CCT7 | T-complex protein 1 subunit eta (TCP-1-eta) (CCT-eta) (HIV-1 Nef-interacting protein) [Cleaved into: T-complex protein 1 subunit eta, N-terminally processed] | 5 | UniProt NCBI |
| DTL | Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein) | 5 | UniProt NCBI |
| CCT3 | T-complex protein 1 subunit gamma (TCP-1-gamma) (CCT-gamma) (hTRiC5) | 5 | UniProt NCBI |
| DCAF12 | DDB1- and CUL4-associated factor 12 (Centrosome-related protein TCC52) (Testis cancer centrosome-related protein) (WD repeat-containing protein 40A) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:126 | 5.49353690762e-07 | 0.375 | CCT5 CCT3 CCT7 | CCT complex (chaperonin containing TCP1 complex) |
| REAC:R-HSA-390450 | 2.74368957961e-06 | 0.375 | CCT5 CCT3 CCT7 | Folding of actin by CCT/TriC |
| GO:0140535 | 4.89541721592e-06 | 1.0 | CCT7 DCAF13 FBXW8 DCAF12 CCT3 CCT5 DCAF5 DTL | intracellular protein-containing complex |
| REAC:R-HSA-389960 | 5.23852014749e-05 | 0.375 | CCT5 CCT3 CCT7 | Formation of tubulin folding intermediates by CCT/TriC |
| REAC:R-HSA-389957 | 6.65860913492e-05 | 0.375 | CCT5 CCT3 CCT7 | Prefoldin mediated transfer of substrate to CCT/TriC |
| GO:0080008 | 0.00010773781481 | 0.5 | DCAF5 DCAF12 DCAF13 DTL | Cul4-RING E3 ubiquitin ligase complex |
| REAC:R-HSA-389958 | 0.000112766844535 | 0.375 | CCT5 CCT3 CCT7 | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding |
| REAC:R-HSA-6814122 | 0.000148687552241 | 0.375 | CCT5 CCT3 CCT7 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
| REAC:R-HSA-390471 | 0.000162162924374 | 0.375 | CCT5 CCT3 CCT7 | Association of TriC/CCT with target proteins during biosynthesis |
| REAC:R-HSA-392499 | 0.000450218945101 | 0.875 | CCT7 DCAF13 FBXW8 CCT3 CCT5 DCAF5 DTL | Metabolism of proteins |
| GO:0031461 | 0.000530546258616 | 0.625 | DCAF5 DCAF12 DTL DCAF13 FBXW8 | cullin-RING ubiquitin ligase complex |
| WP:WP4949 | 0.000551678502006 | 0.375 | CCT5 CCT3 CCT7 | 16p11 2 proximal deletion syndrome |
| GO:0005832 | 0.000644767051209 | 0.375 | CCT5 CCT3 CCT7 | chaperonin-containing T-complex |
| GO:1904851 | 0.000644767051209 | 0.375 | CCT5 CCT3 CCT7 | positive regulation of establishment of protein localization to telomere |
| REAC:R-HSA-8951664 | 0.000776134882135 | 0.5 | DCAF5 DTL DCAF13 FBXW8 | Neddylation |
| GO:1904871 | 0.000886327111509 | 0.375 | CCT5 CCT3 CCT7 | positive regulation of protein localization to Cajal body |
| GO:1904869 | 0.000886327111509 | 0.375 | CCT5 CCT3 CCT7 | regulation of protein localization to Cajal body |
| GO:0070203 | 0.000886327111509 | 0.375 | CCT5 CCT3 CCT7 | regulation of establishment of protein localization to telomere |
| CORUM:6247 | 0.00107416462378 | 0.25 | CCT5 CCT3 | BBS-chaperonin complex |
| GO:1903405 | 0.00118146610329 | 0.375 | CCT5 CCT3 CCT7 | protein localization to nuclear body |
| GO:1904867 | 0.00118146610329 | 0.375 | CCT5 CCT3 CCT7 | protein localization to Cajal body |
| GO:0070202 | 0.00118146610329 | 0.375 | CCT5 CCT3 CCT7 | regulation of establishment of protein localization to chromosome |
| GO:1904816 | 0.00153551162834 | 0.375 | CCT5 CCT3 CCT7 | positive regulation of protein localization to chromosome, telomeric region |
| GO:1990173 | 0.00195378579303 | 0.375 | CCT5 CCT3 CCT7 | protein localization to nucleoplasm |
| REAC:R-HSA-390466 | 0.00221515749645 | 0.375 | CCT5 CCT3 CCT7 | Chaperonin-mediated protein folding |
| GO:1904874 | 0.00244160521127 | 0.375 | CCT5 CCT3 CCT7 | positive regulation of telomerase RNA localization to Cajal body |
| GO:1904814 | 0.00244160521127 | 0.375 | CCT5 CCT3 CCT7 | regulation of protein localization to chromosome, telomeric region |
| REAC:R-HSA-391251 | 0.00281136504087 | 0.375 | CCT5 CCT3 CCT7 | Protein folding |
| GO:0015630 | 0.00285315545087 | 0.875 | CCT7 DCAF13 FBXW8 DCAF12 CCT3 CCT5 DTL | microtubule cytoskeleton |
| GO:0070200 | 0.00300428100757 | 0.375 | CCT5 CCT3 CCT7 | establishment of protein localization to telomere |
| GO:1904872 | 0.0043754188034 | 0.375 | CCT5 CCT3 CCT7 | regulation of telomerase RNA localization to Cajal body |
| GO:0090685 | 0.00519447563198 | 0.375 | CCT5 CCT3 CCT7 | RNA localization to nucleus |
| GO:0090672 | 0.00519447563198 | 0.375 | CCT5 CCT3 CCT7 | telomerase RNA localization |
| GO:0090671 | 0.00519447563198 | 0.375 | CCT5 CCT3 CCT7 | telomerase RNA localization to Cajal body |
| GO:0090670 | 0.00519447563198 | 0.375 | CCT5 CCT3 CCT7 | RNA localization to Cajal body |
| GO:0000151 | 0.00642005344206 | 0.625 | DCAF5 DCAF12 DTL DCAF13 FBXW8 | ubiquitin ligase complex |
| REAC:R-HSA-5620922 | 0.0116541924374 | 0.25 | CCT5 CCT3 | BBSome-mediated cargo-targeting to cilium |
| GO:0070199 | 0.0139126682532 | 0.375 | CCT5 CCT3 CCT7 | establishment of protein localization to chromosome |
| GO:0070198 | 0.0217028525661 | 0.375 | CCT5 CCT3 CCT7 | protein localization to chromosome, telomeric region |
| GO:0032212 | 0.0240219853832 | 0.375 | CCT5 CCT3 CCT7 | positive regulation of telomere maintenance via telomerase |
| GO:0071897 | 0.0298370680549 | 0.5 | CCT5 CCT3 DTL CCT7 | DNA biosynthetic process |
| GO:1904358 | 0.0319547930493 | 0.375 | CCT5 CCT3 CCT7 | positive regulation of telomere maintenance via telomere lengthening |
| GO:0044183 | 0.0414601269437 | 0.375 | CCT5 CCT3 CCT7 | protein folding chaperone |
| GO:0005856 | 0.0483717117681 | 0.875 | CCT7 DCAF13 FBXW8 DCAF12 CCT3 CCT5 DTL | cytoskeleton |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CCT5 | CCT7 | 1.0 | 0.994 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| CCT5 | CCT3 | 1.0 | 0.992 | hein_WMM bioplex3_HEK293 bioplex () Guru bioplex3_WMM boldt hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM bioplex_WMM |
| CCT7 | CCT3 | 0.999 | 0.996 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| DCAF13 | CCT7 | 0.998 | 0.4 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM treiber_WMM |
| DCAF13 | CCT3 | 0.997 | 0.254 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM treiber_WMM |
| CCT5 | DTL | 0.997 | 0.408 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| DTL | CCT3 | 0.997 | 0.372 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| FBXW8 | CCT7 | 0.996 | 0.21 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
| CCT7 | DTL | 0.995 | 0.3576 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| DCAF13 | CCT5 | 0.99 | 0.296 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM treiber_WMM WMM_only |
| DTL | DCAF12 | 0.984 | 0.138 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| FBXW8 | CCT3 | 0.983 | 0.41 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
| CCT3 | DCAF12 | 0.981 | 0.348 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CCT7 | DCAF12 | 0.979 | 0.227666666667 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| DCAF5 | CCT3 | 0.976 | 0.289 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
| DCAF5 | DCAF13 | 0.973 | 0.06 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| DCAF5 | CCT7 | 0.972 | 0.172 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
| DCAF5 | CCT5 | 0.969 | 0.376 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
| CCT5 | DCAF12 | 0.938 | 0.15 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| FBXW8 | DTL | 0.82 | 0.17 | bioplex_WMM bioplex3_WMM WMM_only |
| DCAF13 | DTL | 0.812 | 0.078 | bioplex_WMM bioplex3_WMM WMM_only |
| FBXW8 | CCT5 | 0.777 | 0.5075 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| DCAF5 | FBXW8 | 0.654 | 0.096 | bioplex_WMM bioplex3_WMM WMM_only |
| DCAF5 | DTL | 0.628 | 0.08 | bioplex_WMM bioplex3_WMM WMM_only |
| DCAF13 | FBXW8 | 0.612 | 0.042 | bioplex_WMM bioplex3_WMM WMM_only |
| DCAF5 | DCAF12 | 0.528 | 0.05 | bioplex_WMM bioplex3_WMM WMM_only |
| DCAF13 | DCAF12 | 0.338 | 0.05 | bioplex_WMM bioplex3_WMM WMM_only |
| FBXW8 | DCAF12 | 0.301 | 0.122 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes