hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01952.1
Complex Portal: CPX-14269
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PTCH1 | Protein patched homolog 1 (PTC) (PTC1) | 5 | UniProt NCBI |
| ENPP1 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (E-NPP 1) (Membrane component chromosome 6 surface marker 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Cleaved into: Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form] [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (NPPase) (EC 3.6.1.9) (Nucleotide diphosphatase)] | 5 | UniProt NCBI |
| PLXND1 | Plexin-D1 | 5 | UniProt NCBI |
| GUCD1 | Protein GUCD1 (Guanylyl cyclase domain-containing protein 1) (Protein LLN4) | 5 | UniProt NCBI |
| ST8SIA6 | Alpha-2,8-sialyltransferase 8F (EC 2.4.99.-) (Sialyltransferase 8F) (SIAT8-F) (Sialyltransferase St8Sia VI) (ST8SiaVI) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP474 | 0.00631928190743 | 0.4 | PTCH1 ENPP1 | Endochondral ossification |
| WP:WP4808 | 0.00631928190743 | 0.4 | PTCH1 ENPP1 | Endochondral ossification with skeletal dysplasias |
| HP:0010660 | 0.0337209222644 | 0.4 | PTCH1 ENPP1 | Abnormal hand bone ossification |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ENPP1 | PTCH1 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| PTCH1 | ST8SIA6 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| PTCH1 | PLXND1 | 0.995 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| PTCH1 | GUCD1 | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ENPP1 | PLXND1 | 0.805 | 0.046 | bioplex3_WMM WMM_only | |
| ENPP1 | ST8SIA6 | 0.586 | bioplex3_WMM WMM_only | ||
| PLXND1 | ST8SIA6 | 0.468 | bioplex3_WMM WMM_only | ||
| GUCD1 | ST8SIA6 | 0.055 | bioplex3_WMM WMM_only | ||
| ENPP1 | GUCD1 | 0.047 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PLXND1 | GUCD1 | 0.042 | bioplex3_WMM WMM_only |
Related Complexes