hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_01980.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PHLDB3 | Pleckstrin homology-like domain family B member 3 | 3 | UniProt NCBI |
| IQCB1 | IQ calmodulin-binding motif-containing protein 1 (Nephrocystin-5) (p53 and DNA damage-regulated IQ motif protein) (PIQ) | 5 | UniProt NCBI |
| CEP290 | Centrosomal protein of 290 kDa (Cep290) (Bardet-Biedl syndrome 14 protein) (Cancer/testis antigen 87) (CT87) (Nephrocystin-6) (Tumor antigen se2-2) | 5 | UniProt NCBI |
| CCP110 | Centriolar coiled-coil protein of 110 kDa (Centrosomal protein of 110 kDa) (CP110) (Cep110) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6597 | 5.12628525639e-06 | 0.5 | IQCB1 CEP290 | CEP290-IQCB1 complex |
| CORUM:6594 | 5.12628525639e-06 | 0.5 | CEP290 CCP110 | CCP110-CEP290 complex |
| REAC:R-HSA-5620912 | 0.000181248084935 | 0.75 | IQCB1 CCP110 CEP290 | Anchoring of the basal body to the plasma membrane |
| REAC:R-HSA-5617833 | 0.00153910156762 | 0.75 | IQCB1 CCP110 CEP290 | Cilium Assembly |
| REAC:R-HSA-1852241 | 0.00474364374959 | 0.75 | IQCB1 CCP110 CEP290 | Organelle biogenesis and maintenance |
| WP:WP4656 | 0.0063063631888 | 0.5 | CEP290 CCP110 | Joubert syndrome |
| WP:WP5234 | 0.00722934152515 | 0.5 | IQCB1 CEP290 | Bardet Biedl syndrome |
| HP:0000090 | 0.018706736024 | 0.5 | IQCB1 CEP290 | Nephronophthisis |
| REAC:R-HSA-380259 | 0.0218635493976 | 0.5 | CEP290 CCP110 | Loss of Nlp from mitotic centrosomes |
| REAC:R-HSA-380284 | 0.0218635493976 | 0.5 | CEP290 CCP110 | Loss of proteins required for interphase microtubule organization from the centrosome |
| HP:0001141 | 0.0234332085093 | 0.5 | IQCB1 CEP290 | Severely reduced visual acuity |
| REAC:R-HSA-8854518 | 0.0239057396727 | 0.5 | CEP290 CCP110 | AURKA Activation by TPX2 |
| HP:0002612 | 0.0246976114972 | 0.5 | IQCB1 CEP290 | Congenital hepatic fibrosis |
| WP:WP4803 | 0.030443565418 | 0.5 | IQCB1 CEP290 | Ciliopathies |
| REAC:R-HSA-380270 | 0.0305753786405 | 0.5 | CEP290 CCP110 | Recruitment of mitotic centrosome proteins and complexes |
| REAC:R-HSA-380287 | 0.0305753786405 | 0.5 | CEP290 CCP110 | Centrosome maturation |
| REAC:R-HSA-2565942 | 0.0346321697685 | 0.5 | CEP290 CCP110 | Regulation of PLK1 Activity at G2/M Transition |
| REAC:R-HSA-380320 | 0.0407325822829 | 0.5 | CEP290 CCP110 | Recruitment of NuMA to mitotic centrosomes |
| HP:0100957 | 0.0476300363671 | 0.5 | IQCB1 CEP290 | Abnormal renal medulla morphology |
| CORUM:6598 | 0.049938562206 | 0.25 | CEP290 | CC2D2A-CEP290 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CCP110 | IQCB1 | 0.995 | 0.256 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| CCP110 | CEP290 | 0.993 | 0.189529204785 | hein_WMM bioplex_WMM bioplex3_WMM gupta () boldt hein () gupta_WMM boldt_WMM |
| IQCB1 | CEP290 | 0.987 | 0.228 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta () boldt hein () gupta_WMM boldt_WMM |
| CCP110 | PHLDB3 | 0.961 | 0.18 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| PHLDB3 | IQCB1 | 0.36 | 0.13 | bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only |
| PHLDB3 | CEP290 | 0.049 | 0.489113636364 | bioplex3_WMM WMM_only |
Related Complexes