hu.MAP 3.0: Complex View

Genename	Protein Name	Uniprot Annotation Score	Links
IRF3	Interferon regulatory factor 3 (IRF-3)	5	UniProt NCBI
PSEN2	Presenilin-2 (PS-2) (EC 3.4.23.-) (AD3LP) (AD5) (E5-1) (STM-2) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit]	5	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP5187	0.0373151717536	0.5	IRF3	mRNA vaccine activation of dendritic cell and induction of IFN 1
WP:WP5116	0.049750157242	0.5	IRF3	SARS CoV 2 B 1 1 7 variant antagonises innate immune activation
REAC:R-HSA-1606341	0.0499419797295	0.5	IRF3	IRF3 mediated activation of type 1 IFN
CORUM:299	0.0499419797295	0.5	IRF3	IRF3-CBP complex
CORUM:467	0.0499419797295	0.5	PSEN2	Gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN)
CORUM:7575	0.0499419797295	0.5	PSEN2	APP-PSEN2 complex

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
IRF3	PSEN2	0.965	0.1		bioplex3_WMM bioplex3_HCT116 WMM_only

Genename	Complexes
IRF3	huMAP3_01993.1 huMAP3_02617.1 huMAP3_04068.1 huMAP3_05514.1 huMAP3_06251.1 huMAP3_06864.1 huMAP3_10471.1 huMAP3_11947.1 huMAP3_13131.1 huMAP3_14654.1 huMAP3_15120.1
PSEN2	huMAP3_01993.1 huMAP3_05514.1 huMAP3_06251.1 huMAP3_06842.1 huMAP3_06864.1 huMAP3_07319.1