hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02004.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PVRIG | Transmembrane protein PVRIG (CD112 receptor) (CD112R) (Poliovirus receptor-related immunoglobulin domain-containing protein) | 5 | UniProt NCBI |
| RTN4R | Reticulon-4 receptor (Nogo receptor) (NgR) (Nogo-66 receptor) | 5 | UniProt NCBI |
| SPCS2 | Signal peptidase complex subunit 2 (Microsomal signal peptidase 25 kDa subunit) (SPase 25 kDa subunit) | 5 | UniProt NCBI |
| SEC11C | Signal peptidase complex catalytic subunit SEC11C (EC 3.4.21.89) (Microsomal signal peptidase 21 kDa subunit) (SPase 21 kDa subunit) (SEC11 homolog C) (SEC11-like protein 3) (SPC21) | 5 | UniProt NCBI |
| TREM1 | Triggering receptor expressed on myeloid cells 1 (TREM-1) (Triggering receptor expressed on monocytes 1) (CD antigen CD354) | 5 | UniProt NCBI |
| SPCS3 | Signal peptidase complex subunit 3 (Microsomal signal peptidase 22/23 kDa subunit) (SPC22/23) (SPase 22/23 kDa subunit) | 5 | UniProt NCBI |
| SPCS1 | Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) (SPase 12 kDa subunit) | 5 | UniProt NCBI |
| SEC11A | Signal peptidase complex catalytic subunit SEC11A (EC 3.4.21.89) (Endopeptidase SP18) (Microsomal signal peptidase 18 kDa subunit) (SPase 18 kDa subunit) (SEC11 homolog A) (SEC11-like protein 1) (SPC18) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0005787 | 5.04245888889e-13 | 0.625 | SEC11C SEC11A SPCS1 SPCS2 SPCS3 | signal peptidase complex |
| REAC:R-HSA-400511 | 9.9030847038e-13 | 0.625 | SEC11C SEC11A SPCS1 SPCS2 SPCS3 | Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| REAC:R-HSA-422085 | 2.75777208465e-12 | 0.625 | SEC11C SEC11A SPCS1 SPCS2 SPCS3 | Synthesis, secretion, and deacylation of Ghrelin |
| REAC:R-HSA-381771 | 1.32505130306e-11 | 0.625 | SEC11C SEC11A SPCS1 SPCS2 SPCS3 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) |
| REAC:R-HSA-400508 | 2.48907893667e-11 | 0.625 | SEC11C SEC11A SPCS1 SPCS2 SPCS3 | Incretin synthesis, secretion, and inactivation |
| KEGG:03060 | 7.08426695799e-11 | 0.625 | SEC11C SEC11A SPCS1 SPCS2 SPCS3 | Protein export |
| GO:0006465 | 6.48076439894e-10 | 0.625 | SEC11C SEC11A SPCS1 SPCS2 SPCS3 | signal peptide processing |
| REAC:R-HSA-2980736 | 1.89767508344e-08 | 0.625 | SEC11C SEC11A SPCS1 SPCS2 SPCS3 | Peptide hormone metabolism |
| WP:WP5408 | 1.20125766468e-07 | 0.5 | SPCS3 SEC11A SPCS2 SPCS1 | 15q25 copy number variation |
| REAC:R-HSA-1799339 | 2.5792903836e-07 | 0.625 | SEC11C SEC11A SPCS1 SPCS2 SPCS3 | SRP-dependent cotranslational protein targeting to membrane |
| REAC:R-HSA-72766 | 3.25838980471e-05 | 0.625 | SEC11C SEC11A SPCS1 SPCS2 SPCS3 | Translation |
| GO:1905368 | 3.73496867515e-05 | 0.625 | SEC11C SEC11A SPCS1 SPCS2 SPCS3 | peptidase complex |
| GO:0140534 | 4.78619713005e-05 | 0.625 | SEC11C SEC11A SPCS1 SPCS2 SPCS3 | endoplasmic reticulum protein-containing complex |
| GO:0016485 | 0.000415640824511 | 0.625 | SEC11C SEC11A SPCS1 SPCS2 SPCS3 | protein processing |
| GO:0045047 | 0.0175209574744 | 0.375 | SPCS3 SPCS2 SPCS1 | protein targeting to ER |
| GO:0072599 | 0.0240219853832 | 0.375 | SPCS3 SPCS2 SPCS1 | establishment of protein localization to endoplasmic reticulum |
| GO:0051604 | 0.0345694499007 | 0.625 | SEC11C SEC11A SPCS1 SPCS2 SPCS3 | protein maturation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SPCS2 | SPCS3 | 1.0 | 0.946 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM treiber_WMM |
| SPCS3 | SEC11A | 1.0 | 0.928 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM WMM_only |
| SPCS1 | SEC11C | 1.0 | 0.054 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| SPCS2 | SEC11C | 0.999 | 0.212 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| SEC11C | SPCS3 | 0.999 | 0.138 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| SPCS1 | SPCS3 | 0.998 | 0.822 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| SPCS1 | SPCS2 | 0.997 | 0.646 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| SPCS1 | SEC11A | 0.997 | 0.606 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| SPCS1 | PVRIG | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PVRIG | SPCS2 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SPCS2 | SEC11A | 0.995 | 0.9 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM treiber_WMM |
| SPCS1 | RTN4R | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SPCS1 | TREM1 | 0.991 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TREM1 | SPCS2 | 0.983 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RTN4R | SPCS2 | 0.98 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SEC11C | SEC11A | 0.973 | 0.17 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM |
| PVRIG | SPCS3 | 0.91 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RTN4R | SEC11A | 0.903 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TREM1 | SEC11A | 0.898 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TREM1 | SPCS3 | 0.893 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PVRIG | SEC11A | 0.839 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RTN4R | SPCS3 | 0.817 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
Related Complexes