hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02019.1
Complex Portal: CPX-22695
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| THOC3 | THO complex subunit 3 (Tho3) (TEX1 homolog) (hTREX45) | 5 | UniProt NCBI |
| DDX39A | ATP-dependent RNA helicase DDX39A (EC 3.6.4.13) (DEAD box protein 39) (Nuclear RNA helicase URH49) | 5 | UniProt NCBI |
| THOC2 | THO complex subunit 2 (Tho2) (hTREX120) | 5 | UniProt NCBI |
| ZC3H11A | Zinc finger CCCH domain-containing protein 11A | 5 | UniProt NCBI |
| SPEN | Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) | 5 | UniProt NCBI |
| DDX39B | Spliceosome RNA helicase DDX39B (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (DEAD box protein UAP56) (HLA-B-associated transcript 1 protein) | 5 | UniProt NCBI |
| THOC7 | THO complex subunit 7 homolog (Functional spliceosome-associated protein 24) (fSAP24) (Ngg1-interacting factor 3-like protein 1-binding protein 1) (NIF3L1-binding protein 1) (hTREX30) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-72187 | 2.90019156634e-12 | 0.857142857143 | THOC2 THOC7 THOC3 DDX39B ZC3H11A DDX39A | mRNA 3'-end processing |
| REAC:R-HSA-73856 | 6.7942212876e-12 | 0.857142857143 | THOC2 THOC7 THOC3 DDX39B ZC3H11A DDX39A | RNA Polymerase II Transcription Termination |
| REAC:R-HSA-159236 | 1.31055573088e-11 | 0.857142857143 | THOC2 THOC7 THOC3 DDX39B ZC3H11A DDX39A | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| REAC:R-HSA-72202 | 2.77687349614e-11 | 0.857142857143 | THOC2 THOC7 THOC3 DDX39B ZC3H11A DDX39A | Transport of Mature Transcript to Cytoplasm |
| CORUM:770 | 6.72590627404e-11 | 0.571428571429 | DDX39B THOC3 THOC7 THOC2 | TREX complex |
| GO:0000346 | 8.73008139488e-11 | 0.714285714286 | THOC7 DDX39B THOC3 ZC3H11A THOC2 | transcription export complex |
| GO:0006406 | 2.34362810727e-09 | 0.857142857143 | THOC2 THOC7 THOC3 DDX39B ZC3H11A DDX39A | mRNA export from nucleus |
| GO:0051028 | 4.02863197747e-09 | 0.857142857143 | THOC2 THOC7 THOC3 DDX39B ZC3H11A DDX39A | mRNA transport |
| GO:0006405 | 1.12685593968e-08 | 0.857142857143 | THOC2 THOC7 THOC3 DDX39B ZC3H11A DDX39A | RNA export from nucleus |
| GO:0044417 | 3.22170910527e-08 | 0.571428571429 | DDX39B THOC3 THOC7 THOC2 | translocation of molecules into host |
| GO:0046784 | 3.22170910527e-08 | 0.571428571429 | DDX39B THOC3 THOC7 THOC2 | viral mRNA export from host cell nucleus |
| GO:0050657 | 4.65038977351e-08 | 0.857142857143 | THOC2 THOC7 THOC3 DDX39B ZC3H11A DDX39A | nucleic acid transport |
| GO:0050658 | 4.65038977351e-08 | 0.857142857143 | THOC2 THOC7 THOC3 DDX39B ZC3H11A DDX39A | RNA transport |
| REAC:R-HSA-72203 | 5.49269500155e-08 | 0.857142857143 | THOC2 THOC7 THOC3 DDX39B ZC3H11A DDX39A | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0051236 | 5.51041937092e-08 | 0.857142857143 | THOC2 THOC7 THOC3 DDX39B ZC3H11A DDX39A | establishment of RNA localization |
| CORUM:6160 | 1.4038119659e-07 | 0.428571428571 | THOC7 THOC3 THOC2 | hTREX84 complex |
| CORUM:351 | 1.45258866673e-07 | 0.714285714286 | SPEN DDX39B THOC3 THOC7 THOC2 | Spliceosome |
| GO:0006403 | 2.40939570538e-07 | 0.857142857143 | THOC2 THOC7 THOC3 DDX39B ZC3H11A DDX39A | RNA localization |
| GO:0051168 | 2.62719036755e-07 | 0.857142857143 | THOC2 THOC7 THOC3 DDX39B ZC3H11A DDX39A | nuclear export |
| GO:0015931 | 3.52298201497e-07 | 0.857142857143 | THOC2 THOC7 THOC3 DDX39B ZC3H11A DDX39A | nucleobase-containing compound transport |
| KEGG:03013 | 3.86279110966e-06 | 0.571428571429 | DDX39B THOC3 THOC7 THOC2 | Nucleocytoplasmic transport |
| GO:0006913 | 6.69009408827e-06 | 0.857142857143 | THOC2 THOC7 THOC3 DDX39B ZC3H11A DDX39A | nucleocytoplasmic transport |
| GO:0051169 | 6.69009408827e-06 | 0.857142857143 | THOC2 THOC7 THOC3 DDX39B ZC3H11A DDX39A | nuclear transport |
| REAC:R-HSA-8953854 | 1.34047597764e-05 | 0.857142857143 | THOC2 THOC7 THOC3 DDX39B ZC3H11A DDX39A | Metabolism of RNA |
| GO:0000445 | 6.72425931667e-05 | 0.428571428571 | THOC7 THOC3 THOC2 | THO complex part of transcription export complex |
| GO:0000347 | 6.72425931667e-05 | 0.428571428571 | THOC7 THOC3 THOC2 | THO complex |
| CORUM:774 | 0.000205125012531 | 0.285714285714 | THOC7 THOC2 | THO complex |
| REAC:R-HSA-73857 | 0.000287702038124 | 0.857142857143 | THOC2 THOC7 THOC3 DDX39B ZC3H11A DDX39A | RNA Polymerase II Transcription |
| REAC:R-HSA-74160 | 0.000606041928511 | 0.857142857143 | THOC2 THOC7 THOC3 DDX39B ZC3H11A DDX39A | Gene expression (Transcription) |
| KEGG:03040 | 0.00108816732534 | 0.428571428571 | DDX39B THOC3 THOC2 | Spliceosome |
| HPA:0380513 | 0.00501711431845 | 0.714285714286 | SPEN DDX39B THOC3 ZC3H11A THOC2 | placenta; decidual cells[High] |
| GO:0051701 | 0.00603498380297 | 0.571428571429 | DDX39B THOC3 THOC7 THOC2 | biological process involved in interaction with host |
| HPA:0620222 | 0.00635889715139 | 1.0 | THOC2 DDX39B SPEN THOC3 THOC7 ZC3H11A DDX39A | vagina; squamous epithelial cells[>=Medium] |
| HPA:0320102 | 0.0187790608236 | 1.0 | THOC2 DDX39B SPEN THOC3 THOC7 ZC3H11A DDX39A | nasopharynx; respiratory epithelial cells[>=Medium] |
| HPA:0220053 | 0.0189814837133 | 0.857142857143 | THOC2 THOC7 SPEN THOC3 DDX39B ZC3H11A | gallbladder; glandular cells[High] |
| REAC:R-HSA-9706574 | 0.0225049419259 | 0.285714285714 | SPEN DDX39B | RHOBTB GTPase Cycle |
| HPA:0060102 | 0.0236204382134 | 1.0 | THOC2 DDX39B SPEN THOC3 THOC7 ZC3H11A DDX39A | bronchus; respiratory epithelial cells[>=Medium] |
| HPA:0600222 | 0.0259260211515 | 1.0 | THOC2 DDX39B SPEN THOC3 THOC7 ZC3H11A DDX39A | tonsil; squamous epithelial cells[>=Medium] |
| HPA:0190222 | 0.0294038225527 | 1.0 | THOC2 DDX39B SPEN THOC3 THOC7 ZC3H11A DDX39A | esophagus; squamous epithelial cells[>=Medium] |
| HPA:0270351 | 0.0313594015773 | 1.0 | THOC2 DDX39B SPEN THOC3 THOC7 ZC3H11A DDX39A | kidney; cells in glomeruli[>=Low] |
| HPA:0320103 | 0.0318090001371 | 0.714285714286 | SPEN DDX39B THOC3 ZC3H11A THOC2 | nasopharynx; respiratory epithelial cells[High] |
| HPA:0060103 | 0.0350017722259 | 0.714285714286 | SPEN DDX39B THOC3 ZC3H11A THOC2 | bronchus; respiratory epithelial cells[High] |
| HPA:0500000 | 0.0416022514789 | 1.0 | THOC2 DDX39B SPEN THOC3 THOC7 ZC3H11A DDX39A | soft tissue 1 |
| HPA:0340000 | 0.0467997293181 | 1.0 | THOC2 DDX39B SPEN THOC3 THOC7 ZC3H11A DDX39A | ovary |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| THOC3 | THOC7 | 1.0 | 0.1 |
structurally_consistent (Q8NI27)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () Malo bioplex3_HCT116 fraction |
| THOC3 | THOC2 | 1.0 | 0.46 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction |
| THOC2 | THOC7 | 1.0 | 0.332 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () Malo gupta_WMM fraction |
| THOC2 | DDX39B | 0.999 | 0.458 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| THOC3 | ZC3H11A | 0.999 | 0.098 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| ZC3H11A | THOC7 | 0.998 | 0.132 | hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM hein () | |
| ZC3H11A | THOC2 | 0.998 | 0.486 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM | |
| DDX39A | DDX39B | 0.998 | 0.446 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction treiber_WMM | |
| ZC3H11A | DDX39A | 0.996 | 0.184 |
mutually_exclusive (Q96J01)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction |
| DDX39B | THOC7 | 0.996 | 0.242 | hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM hein () gupta_WMM | |
| ZC3H11A | DDX39B | 0.996 | 0.308 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM | |
| DDX39A | THOC2 | 0.989 | 0.174 |
mutually_exclusive (Q96J01)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM fraction treiber_WMM |
| THOC3 | DDX39B | 0.986 | 0.238 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only | |
| THOC3 | DDX39A | 0.974 | 0.128 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex3_WMM youn_WMM gupta_WMM |
| DDX39A | THOC7 | 0.973 | 0.168 |
structurally_consistent (Q8NI27)
|
hein_WMM bioplex3_WMM youn_WMM hein () gupta_WMM fraction |
| ZC3H11A | SPEN | 0.967 | 0.226 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| THOC3 | SPEN | 0.793 | 0.02 | hein_WMM youn_WMM fraction | |
| SPEN | THOC7 | 0.402 | 0.072 | hein_WMM bioplex3_WMM youn_WMM WMM_only | |
| DDX39B | SPEN | 0.275 | 0.142 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| THOC2 | SPEN | 0.21 | 0.242 | hein_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| DDX39A | SPEN | 0.008 | 0.052 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes