hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_02019.1

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
THOC3	THO complex subunit 3 (Tho3) (TEX1 homolog) (hTREX45)	5	UniProt NCBI
DDX39A	ATP-dependent RNA helicase DDX39A (EC 3.6.4.13) (DEAD box protein 39) (Nuclear RNA helicase URH49)	5	UniProt NCBI
THOC2	THO complex subunit 2 (Tho2) (hTREX120)	5	UniProt NCBI
ZC3H11A	Zinc finger CCCH domain-containing protein 11A	5	UniProt NCBI
SPEN	Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog)	5	UniProt NCBI
DDX39B	Spliceosome RNA helicase DDX39B (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (DEAD box protein UAP56) (HLA-B-associated transcript 1 protein)	5	UniProt NCBI
THOC7	THO complex subunit 7 homolog (Functional spliceosome-associated protein 24) (fSAP24) (Ngg1-interacting factor 3-like protein 1-binding protein 1) (NIF3L1-binding protein 1) (hTREX30)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-72187	2.90019156634e-12	0.857142857143	DDX39B THOC7 THOC2 DDX39A ZC3H11A THOC3	mRNA 3'-end processing
REAC:R-HSA-73856	6.7942212876e-12	0.857142857143	DDX39B THOC7 THOC2 DDX39A ZC3H11A THOC3	RNA Polymerase II Transcription Termination
REAC:R-HSA-159236	1.31055573088e-11	0.857142857143	DDX39B THOC7 THOC2 DDX39A ZC3H11A THOC3	Transport of Mature mRNA derived from an Intron-Containing Transcript
REAC:R-HSA-72202	2.77687349614e-11	0.857142857143	DDX39B THOC7 THOC2 DDX39A ZC3H11A THOC3	Transport of Mature Transcript to Cytoplasm
CORUM:770	6.72590627404e-11	0.571428571429	DDX39B THOC7 THOC3 THOC2	TREX complex
GO:0000346	8.73008139488e-11	0.714285714286	DDX39B ZC3H11A THOC7 THOC3 THOC2	transcription export complex
GO:0006406	2.34362810727e-09	0.857142857143	DDX39B THOC7 THOC2 DDX39A ZC3H11A THOC3	mRNA export from nucleus
GO:0051028	4.02863197747e-09	0.857142857143	DDX39B THOC7 THOC2 DDX39A ZC3H11A THOC3	mRNA transport
GO:0006405	1.12685593968e-08	0.857142857143	DDX39B THOC7 THOC2 DDX39A ZC3H11A THOC3	RNA export from nucleus
GO:0044417	3.22170910527e-08	0.571428571429	DDX39B THOC7 THOC3 THOC2	translocation of molecules into host
GO:0046784	3.22170910527e-08	0.571428571429	DDX39B THOC7 THOC3 THOC2	viral mRNA export from host cell nucleus
GO:0050657	4.65038977351e-08	0.857142857143	DDX39B THOC7 THOC2 DDX39A ZC3H11A THOC3	nucleic acid transport
GO:0050658	4.65038977351e-08	0.857142857143	DDX39B THOC7 THOC2 DDX39A ZC3H11A THOC3	RNA transport
REAC:R-HSA-72203	5.49269500155e-08	0.857142857143	DDX39B THOC7 THOC2 DDX39A ZC3H11A THOC3	Processing of Capped Intron-Containing Pre-mRNA
GO:0051236	5.51041937092e-08	0.857142857143	DDX39B THOC7 THOC2 DDX39A ZC3H11A THOC3	establishment of RNA localization
CORUM:6160	1.4038119659e-07	0.428571428571	THOC7 THOC3 THOC2	hTREX84 complex
CORUM:351	1.45258866673e-07	0.714285714286	DDX39B SPEN THOC7 THOC3 THOC2	Spliceosome
GO:0006403	2.40939570538e-07	0.857142857143	DDX39B THOC7 THOC2 DDX39A ZC3H11A THOC3	RNA localization
GO:0051168	2.62719036755e-07	0.857142857143	DDX39B THOC7 THOC2 DDX39A ZC3H11A THOC3	nuclear export
GO:0015931	3.52298201497e-07	0.857142857143	DDX39B THOC7 THOC2 DDX39A ZC3H11A THOC3	nucleobase-containing compound transport
KEGG:03013	3.86279110966e-06	0.571428571429	DDX39B THOC7 THOC3 THOC2	Nucleocytoplasmic transport
GO:0006913	6.69009408827e-06	0.857142857143	DDX39B THOC7 THOC2 DDX39A ZC3H11A THOC3	nucleocytoplasmic transport
GO:0051169	6.69009408827e-06	0.857142857143	DDX39B THOC7 THOC2 DDX39A ZC3H11A THOC3	nuclear transport
REAC:R-HSA-8953854	1.34047597764e-05	0.857142857143	DDX39B THOC7 THOC2 DDX39A ZC3H11A THOC3	Metabolism of RNA
GO:0000445	6.72425931667e-05	0.428571428571	THOC7 THOC3 THOC2	THO complex part of transcription export complex
GO:0000347	6.72425931667e-05	0.428571428571	THOC7 THOC3 THOC2	THO complex
CORUM:774	0.000205125012531	0.285714285714	THOC2 THOC7	THO complex
REAC:R-HSA-73857	0.000287702038124	0.857142857143	DDX39B THOC7 THOC2 DDX39A ZC3H11A THOC3	RNA Polymerase II Transcription
REAC:R-HSA-74160	0.000606041928511	0.857142857143	DDX39B THOC7 THOC2 DDX39A ZC3H11A THOC3	Gene expression (Transcription)
KEGG:03040	0.00108816732534	0.428571428571	DDX39B THOC3 THOC2	Spliceosome
HPA:0380513	0.00501711431845	0.714285714286	DDX39B ZC3H11A SPEN THOC3 THOC2	placenta; decidual cells[High]
GO:0051701	0.00603498380297	0.571428571429	DDX39B THOC7 THOC3 THOC2	biological process involved in interaction with host
HPA:0620222	0.00635889715139	1.0	SPEN DDX39B DDX39A THOC2 THOC7 ZC3H11A THOC3	vagina; squamous epithelial cells[>=Medium]
HPA:0320102	0.0187790608236	1.0	SPEN DDX39B DDX39A THOC2 THOC7 ZC3H11A THOC3	nasopharynx; respiratory epithelial cells[>=Medium]
HPA:0220053	0.0189814837133	0.857142857143	SPEN DDX39B THOC7 THOC2 ZC3H11A THOC3	gallbladder; glandular cells[High]
REAC:R-HSA-9706574	0.0225049419259	0.285714285714	SPEN DDX39B	RHOBTB GTPase Cycle
HPA:0060102	0.0236204382134	1.0	SPEN DDX39B DDX39A THOC2 THOC7 ZC3H11A THOC3	bronchus; respiratory epithelial cells[>=Medium]
HPA:0600222	0.0259260211515	1.0	SPEN DDX39B DDX39A THOC2 THOC7 ZC3H11A THOC3	tonsil; squamous epithelial cells[>=Medium]
HPA:0190222	0.0294038225527	1.0	SPEN DDX39B DDX39A THOC2 THOC7 ZC3H11A THOC3	esophagus; squamous epithelial cells[>=Medium]
HPA:0270351	0.0313594015773	1.0	SPEN DDX39B DDX39A THOC2 THOC7 ZC3H11A THOC3	kidney; cells in glomeruli[>=Low]
HPA:0320103	0.0318090001371	0.714285714286	DDX39B ZC3H11A SPEN THOC3 THOC2	nasopharynx; respiratory epithelial cells[High]
HPA:0060103	0.0350017722259	0.714285714286	DDX39B ZC3H11A SPEN THOC3 THOC2	bronchus; respiratory epithelial cells[High]
HPA:0500000	0.0416022514789	1.0	SPEN DDX39B DDX39A THOC2 THOC7 ZC3H11A THOC3	soft tissue 1
HPA:0340000	0.0467997293181	1.0	SPEN DDX39B DDX39A THOC2 THOC7 ZC3H11A THOC3	ovary

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
THOC3	THOC7	1.0	0.1	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () Malo bioplex3_HCT116 fraction
THOC3	THOC2	1.0	0.46	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction
THOC2	THOC7	1.0	0.332	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () Malo gupta_WMM fraction
THOC2	DDX39B	0.999	0.458	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM
THOC3	ZC3H11A	0.999	0.098	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only
ZC3H11A	THOC7	0.998	0.132	hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM hein ()
ZC3H11A	THOC2	0.998	0.486	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM
DDX39A	DDX39B	0.998	0.446	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction treiber_WMM
ZC3H11A	DDX39A	0.996	0.184	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction
DDX39B	THOC7	0.996	0.242	hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM hein () gupta_WMM
ZC3H11A	DDX39B	0.996	0.308	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM
DDX39A	THOC2	0.989	0.174	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM fraction treiber_WMM
THOC3	DDX39B	0.986	0.238	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only
THOC3	DDX39A	0.974	0.128	hein_WMM bioplex3_HEK293 bioplex () bioplex3_WMM youn_WMM gupta_WMM
DDX39A	THOC7	0.973	0.168	hein_WMM bioplex3_WMM youn_WMM hein () gupta_WMM fraction
ZC3H11A	SPEN	0.967	0.226	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
THOC3	SPEN	0.793	0.02	hein_WMM youn_WMM fraction
SPEN	THOC7	0.402	0.072	hein_WMM bioplex3_WMM youn_WMM WMM_only
DDX39B	SPEN	0.275	0.142	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
THOC2	SPEN	0.21	0.242	hein_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
DDX39A	SPEN	0.008	0.052	bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only

Related Complexes

Genename	Complexes
THOC3	huMAP3_00936.1 huMAP3_02019.1 huMAP3_04872.1 huMAP3_04932.1 huMAP3_06572.1 huMAP3_06628.1 huMAP3_08159.1 huMAP3_08904.1 huMAP3_09101.1 huMAP3_09184.1 huMAP3_09225.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10789.1 huMAP3_12548.1 huMAP3_14379.1
DDX39A	huMAP3_01665.1 huMAP3_02019.1 huMAP3_04872.1 huMAP3_04932.1 huMAP3_05995.1 huMAP3_06628.1 huMAP3_08159.1 huMAP3_08904.1 huMAP3_09101.1 huMAP3_09225.1 huMAP3_09226.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10789.1 huMAP3_12548.1
THOC2	huMAP3_01665.1 huMAP3_02019.1 huMAP3_04872.1 huMAP3_04932.1 huMAP3_05696.1 huMAP3_05995.1 huMAP3_08159.1 huMAP3_08904.1 huMAP3_09101.1 huMAP3_09225.1 huMAP3_09226.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10789.1 huMAP3_12548.1
ZC3H11A	huMAP3_01665.1 huMAP3_02019.1 huMAP3_04872.1 huMAP3_04932.1 huMAP3_05696.1 huMAP3_05846.1 huMAP3_05995.1 huMAP3_08302.1 huMAP3_08820.1 huMAP3_09101.1 huMAP3_09156.1 huMAP3_09226.1 huMAP3_09552.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10564.1 huMAP3_10789.1
SPEN	huMAP3_02019.1 huMAP3_03970.1 huMAP3_05696.1 huMAP3_05995.1 huMAP3_07848.1 huMAP3_08302.1 huMAP3_08486.1 huMAP3_08820.1 huMAP3_09041.1 huMAP3_09156.1 huMAP3_09532.1 huMAP3_09587.1 huMAP3_09943.1 huMAP3_10021.1 huMAP3_10524.1
DDX39B	huMAP3_01665.1 huMAP3_02019.1 huMAP3_04872.1 huMAP3_04932.1 huMAP3_05846.1 huMAP3_05995.1 huMAP3_06628.1 huMAP3_08159.1 huMAP3_08904.1 huMAP3_09101.1 huMAP3_09225.1 huMAP3_09226.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10789.1 huMAP3_12548.1
THOC7	huMAP3_02019.1 huMAP3_02553.1 huMAP3_04872.1 huMAP3_04932.1 huMAP3_06628.1 huMAP3_07273.1 huMAP3_08111.1 huMAP3_08159.1 huMAP3_08233.1 huMAP3_09101.1 huMAP3_09184.1 huMAP3_09225.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10789.1 huMAP3_12548.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_02019.1