hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02022.1
Complex Portal: CPX-13099
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HGS | Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110) | 5 | UniProt NCBI |
| TGM7 | Protein-glutamine gamma-glutamyltransferase Z (Transglutaminase Z) (TG(Z)) (TGZ) (TGase Z) (EC 2.3.2.13) (Transglutaminase-7) (TGase-7) | 5 | UniProt NCBI |
| TCEA1 | Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) (Transcription elongation factor TFIIS.o) | 5 | UniProt NCBI |
| STAM | Signal transducing adapter molecule 1 (STAM-1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7287 | 1.53774525569e-05 | 0.5 | STAM HGS | SIMPLE-HRS-STAM1 complex |
| REAC:R-HSA-8875360 | 0.000931962666506 | 0.5 | STAM HGS | InlB-mediated entry of Listeria monocytogenes into host cell |
| REAC:R-HSA-8876384 | 0.00175047124894 | 0.5 | STAM HGS | Listeria monocytogenes entry into host cells |
| REAC:R-HSA-6807004 | 0.00194479046925 | 0.5 | STAM HGS | Negative regulation of MET activity |
| REAC:R-HSA-182971 | 0.00359044851421 | 0.5 | STAM HGS | EGFR downregulation |
| REAC:R-HSA-917729 | 0.00444848198459 | 0.5 | STAM HGS | Endosomal Sorting Complex Required For Transport (ESCRT) |
| REAC:R-HSA-9013420 | 0.0068064250699 | 0.5 | STAM HGS | RHOU GTPase cycle |
| GO:0033565 | 0.00842684400117 | 0.5 | STAM HGS | ESCRT-0 complex |
| REAC:R-HSA-177929 | 0.00966180252737 | 0.5 | STAM HGS | Signaling by EGFR |
| REAC:R-HSA-9824439 | 0.0174510452107 | 0.5 | STAM HGS | Bacterial Infection Pathways |
| REAC:R-HSA-6806834 | 0.0239057396727 | 0.5 | STAM HGS | Signaling by MET |
| WP:WP437 | 0.0259547050416 | 0.5 | STAM HGS | EGF EGFR signaling pathway |
| REAC:R-HSA-8856825 | 0.0444386798825 | 0.5 | STAM HGS | Cargo recognition for clathrin-mediated endocytosis |
| REAC:R-HSA-9635644 | 0.0499436884912 | 0.25 | HGS | Inhibition of membrane repair |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| HGS | STAM | 1.0 | 0.556 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction | |
| TGM7 | STAM | 0.958 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| TCEA1 | STAM | 0.958 | 0.128 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| HGS | TGM7 | 0.241 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| HGS | TCEA1 | 0.011 | 0.2 | bioplex3_WMM WMM_only |
Related Complexes