hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02023.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| IGF1R | Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] | 5 | UniProt NCBI |
| INSR | Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04913 | 0.000102418907518 | 1.0 | IGF1R INSR | Ovarian steroidogenesis |
| WP:WP5385 | 0.000117475817039 | 1.0 | IGF1R INSR | Growth factors and hormones in Beta cell proliferation |
| KEGG:04213 | 0.000232637232791 | 1.0 | IGF1R INSR | Longevity regulating pathway - multiple species |
| KEGG:04211 | 0.000526725810094 | 1.0 | IGF1R INSR | Longevity regulating pathway |
| KEGG:04520 | 0.0005941922333 | 1.0 | IGF1R INSR | Adherens junction |
| KEGG:04066 | 0.00078862558789 | 1.0 | IGF1R INSR | HIF-1 signaling pathway |
| KEGG:04152 | 0.00102874102663 | 1.0 | IGF1R INSR | AMPK signaling pathway |
| KEGG:04068 | 0.00102874102663 | 1.0 | IGF1R INSR | FoxO signaling pathway |
| HP:0003758 | 0.00119955074999 | 1.0 | IGF1R INSR | Reduced subcutaneous adipose tissue |
| GO:0005009 | 0.00140460216025 | 1.0 | IGF1R INSR | insulin receptor activity |
| WP:WP4540 | 0.00141354053763 | 1.0 | IGF1R INSR | Hippo signaling regulation pathways |
| KEGG:04150 | 0.00176843313648 | 1.0 | IGF1R INSR | mTOR signaling pathway |
| WP:WP4541 | 0.00194090480325 | 1.0 | IGF1R INSR | Hippo Merlin signaling dysregulation |
| KEGG:04015 | 0.00222639196581 | 1.0 | IGF1R INSR | Rap1 signaling pathway |
| KEGG:04014 | 0.00273702337615 | 1.0 | IGF1R INSR | Ras signaling pathway |
| GO:0005899 | 0.0028092043205 | 1.0 | IGF1R INSR | insulin receptor complex |
| GO:0043559 | 0.0028092043205 | 1.0 | IGF1R INSR | insulin binding |
| HP:0040063 | 0.0036943429081 | 1.0 | IGF1R INSR | Decreased adipose tissue |
| WP:WP481 | 0.00432149264637 | 1.0 | IGF1R INSR | Insulin signaling |
| WP:WP4223 | 0.00456751084292 | 1.0 | IGF1R INSR | Ras signaling |
| KEGG:04010 | 0.0047800367266 | 1.0 | IGF1R INSR | MAPK signaling pathway |
| HP:0001001 | 0.00507502240382 | 1.0 | IGF1R INSR | Abnormality of subcutaneous fat tissue |
| KEGG:04151 | 0.00662552789826 | 1.0 | IGF1R INSR | PI3K-Akt signaling pathway |
| GO:0043560 | 0.00702301080125 | 1.0 | IGF1R INSR | insulin receptor substrate binding |
| WP:WP3932 | 0.0130364105952 | 1.0 | IGF1R INSR | Focal adhesion PI3K Akt mTOR signaling pathway |
| WP:WP4172 | 0.015571930313 | 1.0 | IGF1R INSR | PI3K Akt signaling pathway |
| WP:WP5087 | 0.0293715080819 | 1.0 | IGF1R INSR | Pleural mesothelioma |
| GO:0031994 | 0.0309012475255 | 1.0 | IGF1R INSR | insulin-like growth factor I binding |
| WP:WP4186 | 0.0373151717536 | 0.5 | IGF1R | Somatroph axis GH and its relationship to dietary restriction and aging |
| GO:0016500 | 0.0426062655276 | 1.0 | IGF1R INSR | protein-hormone receptor activity |
| GO:0097062 | 0.0426062655276 | 1.0 | IGF1R INSR | dendritic spine maintenance |
| GO:0005520 | 0.0491610756088 | 1.0 | IGF1R INSR | insulin-like growth factor binding |
| WP:WP3634 | 0.049750157242 | 0.5 | INSR | Insulin signaling in adipocytes normal condition |
| WP:WP3635 | 0.049750157242 | 0.5 | INSR | Insulin signaling in adipocytes diabetic condition |
| CORUM:6251 | 0.0499419797295 | 0.5 | IGF1R | Shc-ERalpha-IGF-1R complex |
| HP:0034384 | 0.0499436884913 | 0.5 | INSR | Elevated circulating insulin:C-peptide ratio |
| HP:0012686 | 0.0499436884913 | 0.5 | INSR | Increased pineal volume |
| HP:0012684 | 0.0499436884913 | 0.5 | INSR | Abnormal pineal volume |
| HP:0004914 | 0.0499436884913 | 0.5 | INSR | Recurrent infantile hypoglycemia |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| IGF1R | INSR | 0.988 | 0.15 | hein_WMM bioplex_WMM bioplex3_WMM hein () gupta_WMM |
Related Complexes