hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02031.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase) | 5 | UniProt NCBI |
| BIRC3 | Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (RING-type E3 ubiquitin transferase BIRC3) (TNFR2-TRAF-signaling complex protein 1) | 5 | UniProt NCBI |
| BCL10 | B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CARD-containing molecule enhancing NF-kappa-B) (CARD-like apoptotic protein) (hCLAP) (CED-3/ICH-1 prodomain homologous E10-like regulator) (CIPER) (Cellular homolog of vCARMEN) (cCARMEN) (Cellular-E10) (c-E10) (Mammalian CARD-containing adapter molecule E10) (mE10) | 5 | UniProt NCBI |
| MIS18BP1 | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0012123 | 1.83076395158e-08 | 0.75 | BIRC3 MALT1 BCL10 | Posterior uveitis |
| HP:0012191 | 2.56149077436e-06 | 0.75 | BIRC3 MALT1 BCL10 | B-cell lymphoma |
| CORUM:2753 | 5.12628525639e-06 | 0.5 | BCL10 MALT1 | FYB-CARMA1-BCL-10-MALT1 complex |
| CORUM:2053 | 5.12628525639e-06 | 0.5 | BCL10 MALT1 | BCL10-MALT1 complex |
| CORUM:2752 | 5.12628525639e-06 | 0.5 | BCL10 MALT1 | CARMA1-BCL10-MALT1 complex |
| HP:0100721 | 9.25415545838e-06 | 0.75 | BIRC3 MALT1 BCL10 | Mediastinal lymphadenopathy |
| HP:0012539 | 2.73460533271e-05 | 0.75 | BIRC3 MALT1 BCL10 | Non-Hodgkin lymphoma |
| KEGG:04064 | 2.80928961665e-05 | 0.75 | BIRC3 MALT1 BCL10 | NF-kappa B signaling pathway |
| CORUM:2054 | 3.07520988333e-05 | 0.5 | BCL10 MALT1 | CASP8-FADD-MALT1-BCL10 complex |
| HP:0000554 | 4.17532321542e-05 | 0.75 | BIRC3 MALT1 BCL10 | Uveitis |
| HP:0045026 | 4.51363082059e-05 | 0.75 | BIRC3 MALT1 BCL10 | Abnormal mediastinum morphology |
| CORUM:2745 | 5.12488211613e-05 | 0.5 | BCL10 MALT1 | Ubiquitin E3 ligase (TRAF6, TAB2, MALT1, UEV1A, BCL10) |
| CORUM:2055 | 5.12488211613e-05 | 0.5 | BCL10 MALT1 | CASP8-CHUK-IKBKB-MALT1-BCL10 complex |
| HP:0045027 | 7.40507869872e-05 | 0.75 | BIRC3 MALT1 BCL10 | Abnormality of the thoracic cavity |
| HP:0002113 | 7.89834426977e-05 | 0.75 | BIRC3 MALT1 BCL10 | Pulmonary infiltrates |
| HP:0000614 | 0.000190105075273 | 0.75 | BIRC3 MALT1 BCL10 | Abnormal nasolacrimal system morphology |
| HP:0002665 | 0.000829195350743 | 0.75 | BIRC3 MALT1 BCL10 | Lymphoma |
| HP:0031983 | 0.00124584699949 | 0.75 | BIRC3 MALT1 BCL10 | Abnormal pulmonary thoracic imaging finding |
| HP:0000975 | 0.00199074487028 | 0.75 | BIRC3 MALT1 BCL10 | Hyperhidrosis |
| WP:WP3863 | 0.00299043061896 | 0.5 | BCL10 MALT1 | T cell antigen receptor TCR pathway during Staphylococcus aureus infection |
| WP:WP5072 | 0.0035028118218 | 0.5 | BCL10 MALT1 | Modulators of TCR signaling and T cell activation |
| HP:0100533 | 0.00405200286793 | 0.75 | BIRC3 MALT1 BCL10 | Inflammatory abnormality of the eye |
| WP:WP69 | 0.00464837292584 | 0.5 | BCL10 MALT1 | T cell receptor signaling pathway |
| HP:0007550 | 0.00518180487156 | 0.75 | BIRC3 MALT1 BCL10 | Hypohidrosis or hyperhidrosis |
| HP:0002716 | 0.00526378291815 | 0.75 | BIRC3 MALT1 BCL10 | Lymphadenopathy |
| KEGG:04662 | 0.0056793701001 | 0.5 | BCL10 MALT1 | B cell receptor signaling pathway |
| HP:0025276 | 0.00577380592851 | 0.75 | BIRC3 MALT1 BCL10 | Abnormality of skin adnexa physiology |
| HP:0002733 | 0.00650347944977 | 0.75 | BIRC3 MALT1 BCL10 | Abnormal lymph node morphology |
| WP:WP5098 | 0.00685264055756 | 0.5 | BCL10 MALT1 | T cell activation SARS CoV 2 |
| WP:WP23 | 0.00722934152515 | 0.5 | BCL10 MALT1 | B cell receptor signaling pathway |
| GO:0032449 | 0.00842684400117 | 0.5 | BCL10 MALT1 | CBM complex |
| KEGG:04625 | 0.00888666878999 | 0.5 | BCL10 MALT1 | C-type lectin receptor signaling pathway |
| KEGG:04660 | 0.0130545606238 | 0.5 | BCL10 MALT1 | T cell receptor signaling pathway |
| HP:0004377 | 0.0135364936749 | 0.75 | BIRC3 MALT1 BCL10 | Hematological neoplasm |
| HP:0002027 | 0.0158129816731 | 0.75 | BIRC3 MALT1 BCL10 | Abdominal pain |
| REAC:R-HSA-1169091 | 0.0212029570934 | 0.5 | BCL10 MALT1 | Activation of NF-kappaB in B cells |
| CORUM:2052 | 0.0249718442456 | 0.25 | BCL10 | BCL10 homo-oligomer complex |
| CORUM:2051 | 0.0249718442456 | 0.25 | MALT1 | MALT1 homo-oligomer complex |
| HP:0001824 | 0.0250503832174 | 0.75 | BIRC3 MALT1 BCL10 | Weight loss |
| KEGG:05152 | 0.02620193588 | 0.5 | BCL10 MALT1 | Tuberculosis |
| REAC:R-HSA-1168372 | 0.0275106007785 | 0.5 | BCL10 MALT1 | Downstream signaling events of B Cell Receptor (BCR) |
| REAC:R-HSA-2871837 | 0.0282617295192 | 0.5 | BCL10 MALT1 | FCERI mediated NF-kB activation |
| HP:0001945 | 0.0297221025438 | 0.75 | BIRC3 MALT1 BCL10 | Fever |
| HP:0002019 | 0.0385249398527 | 0.75 | BIRC3 MALT1 BCL10 | Constipation |
| REAC:R-HSA-202424 | 0.0398310607487 | 0.5 | BCL10 MALT1 | Downstream TCR signaling |
| REAC:R-HSA-5607764 | 0.0407325822829 | 0.5 | BCL10 MALT1 | CLEC7A (Dectin-1) signaling |
| GO:0031398 | 0.0434703685672 | 0.75 | BIRC3 MALT1 BCL10 | positive regulation of protein ubiquitination |
| HP:0012378 | 0.0453746914491 | 0.75 | BIRC3 MALT1 BCL10 | Fatigue |
| REAC:R-HSA-983705 | 0.046351696636 | 0.5 | BCL10 MALT1 | Signaling by the B Cell Receptor (BCR) |
| CORUM:2744 | 0.049938562206 | 0.25 | MALT1 | TRAF2-MALT1 complex |
| CORUM:2743 | 0.049938562206 | 0.25 | MALT1 | TRAF6-MALT1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| BCL10 | MALT1 | 0.998 | 0.226 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| BIRC3 | BCL10 | 0.996 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| BCL10 | MIS18BP1 | 0.951 | 0.044 | hein_WMM bioplex3_WMM WMM_only |
| BIRC3 | MALT1 | 0.255 | bioplex3_WMM WMM_only |
Related Complexes