hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_02035.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CYP2B6 | Cytochrome P450 2B6 (EC 1.14.13.-) (1,4-cineole 2-exo-monooxygenase) (CYPIIB6) (Cytochrome P450 IIB1) | 5 | UniProt NCBI |
| PGRMC1 | Membrane-associated progesterone receptor component 1 (mPR) (Dap1) (IZA) | 5 | UniProt NCBI |
| CYP1A2 | Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (Cholesterol 25-hydroxylase) (Cytochrome P(3)450) (Cytochrome P450 4) (Cytochrome P450-P3) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP299 | 0.000286309588192 | 0.666666666667 | CYP2B6 CYP1A2 | Nuclear receptors in lipid metabolism and toxicity |
| KEGG:00830 | 0.000971121931852 | 0.666666666667 | CYP2B6 CYP1A2 | Retinol metabolism |
| WP:WP43 | 0.000973512535349 | 0.666666666667 | CYP2B6 CYP1A2 | Oxidation by cytochrome P450 |
| KEGG:00982 | 0.001089792048 | 0.666666666667 | CYP2B6 CYP1A2 | Drug metabolism - cytochrome P450 |
| KEGG:00980 | 0.00130273084965 | 0.666666666667 | CYP2B6 CYP1A2 | Metabolism of xenobiotics by cytochrome P450 |
| REAC:R-HSA-211981 | 0.00143063482691 | 0.666666666667 | CYP2B6 CYP1A2 | Xenobiotics |
| GO:0020037 | 0.00549374094772 | 1.0 | CYP1A2 CYP2B6 PGRMC1 | heme binding |
| REAC:R-HSA-211897 | 0.00673703034894 | 0.666666666667 | CYP2B6 CYP1A2 | Cytochrome P450 - arranged by substrate type |
| GO:0046906 | 0.00703118100474 | 1.0 | CYP1A2 CYP2B6 PGRMC1 | tetrapyrrole binding |
| KEGG:05207 | 0.0100047546179 | 0.666666666667 | CYP2B6 CYP1A2 | Chemical carcinogenesis - receptor activation |
| WP:WP702 | 0.0101834993772 | 0.666666666667 | CYP2B6 CYP1A2 | Metapathway biotransformation Phase I and II |
| HPA:0290403 | 0.0104715066022 | 1.0 | CYP1A2 CYP2B6 PGRMC1 | liver; hepatocytes[High] |
| GO:0101021 | 0.0140440992017 | 0.666666666667 | CYP2B6 CYP1A2 | estrogen 2-hydroxylase activity |
| WP:WP2646 | 0.0165527833611 | 0.333333333333 | CYP1A2 | Lidocaine metabolism |
| REAC:R-HSA-211945 | 0.019882541548 | 0.666666666667 | CYP2B6 CYP1A2 | Phase I - Functionalization of compounds |
| WP:WP1600 | 0.0248274760036 | 0.333333333333 | CYP2B6 | Nicotine metabolism in liver cells |
| KEGG:00232 | 0.0278821167741 | 0.333333333333 | CYP1A2 | Caffeine metabolism |
| WP:WP694 | 0.0331010360575 | 0.333333333333 | CYP1A2 | Arylamine metabolism |
| WP:WP2542 | 0.0331010360575 | 0.333333333333 | CYP1A2 | Sulindac metabolic pathway |
| WP:WP3633 | 0.0331010360575 | 0.333333333333 | CYP1A2 | Caffeine and theobromine metabolism |
| WP:WP2491 | 0.0331010360575 | 0.333333333333 | CYP2B6 | Diclofenac metabolic pathway |
| WP:WP2882 | 0.0351361093338 | 0.666666666667 | CYP2B6 CYP1A2 | Nuclear receptors meta pathway |
| REAC:R-HSA-211957 | 0.0498224659464 | 0.333333333333 | CYP1A2 | Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 |
| CORUM:1990 | 0.0499402709677 | 0.333333333333 | PGRMC1 | PGRMC1-SCAP complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PGRMC1 | CYP1A2 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CYP2B6 | PGRMC1 | 0.958 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
Related Complexes
| Genename | Complexes |
|---|---|
| CYP2B6 | huMAP3_02035.1 huMAP3_11806.1 huMAP3_12646.1 huMAP3_14673.1 |
| PGRMC1 | huMAP3_02035.1 huMAP3_11806.1 |
| CYP1A2 | huMAP3_02035.1 huMAP3_12549.1 huMAP3_13373.1 huMAP3_15172.1 |