hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_02063.1

Complex Portal: CPX-18631

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
PAG1	Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp)	5	UniProt NCBI
CSK	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL)	5	UniProt NCBI
MATK	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (CSK homologous kinase) (CHK) (Hematopoietic consensus tyrosine-lacking kinase) (Protein kinase HYL) (Tyrosine-protein kinase CTK)	5	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-180292	0.000620139908703	0.666666666667	CSK PAG1	GAB1 signalosome
REAC:R-HSA-202427	0.000926675585137	0.666666666667	CSK PAG1	Phosphorylation of CD3 and TCR zeta chains
REAC:R-HSA-9006934	0.00622622698696	1.0	CSK PAG1 MATK	Signaling by Receptor Tyrosine Kinases
REAC:R-HSA-177929	0.00643790104829	0.666666666667	CSK PAG1	Signaling by EGFR
REAC:R-HSA-202403	0.0377646799279	0.666666666667	CSK PAG1	TCR signaling

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
CSK	MATK	0.998			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
PAG1	CSK	0.968	0.08		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
PAG1	MATK	0.143			bioplex_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
PAG1	huMAP3_02043.1 huMAP3_02063.1 huMAP3_05554.1 huMAP3_07075.1 huMAP3_12303.1 huMAP3_12658.1 huMAP3_15211.1
CSK	huMAP3_02063.1 huMAP3_11660.1 huMAP3_15189.1
MATK	huMAP3_02063.1 huMAP3_11660.1 huMAP3_15189.1