hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02064.1
Complex Portal: CPX-24355
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HK2 | Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Hexokinase-B) (Muscle form hexokinase) | 5 | UniProt NCBI |
| HK3 | Hexokinase-3 (EC 2.7.1.1) (Hexokinase type III) (HK III) (Hexokinase-C) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00524 | 1.62569694473e-06 | 1.0 | HK2 HK3 | Neomycin, kanamycin and gentamicin biosynthesis |
| WP:WP5394 | 1.91536658216e-05 | 1.0 | HK2 HK3 | UDP derived sugars synthesis in fibroblasts |
| KEGG:00500 | 4.8770908342e-05 | 1.0 | HK2 HK3 | Starch and sucrose metabolism |
| KEGG:00052 | 5.28351507038e-05 | 1.0 | HK2 HK3 | Galactose metabolism |
| KEGG:00051 | 9.12015985996e-05 | 1.0 | HK2 HK3 | Fructose and mannose metabolism |
| KEGG:04973 | 9.67289682117e-05 | 1.0 | HK2 HK3 | Carbohydrate digestion and absorption |
| KEGG:01250 | 9.67289682117e-05 | 1.0 | HK2 HK3 | Biosynthesis of nucleotide sugars |
| KEGG:04930 | 0.000133307149468 | 1.0 | HK2 HK3 | Type II diabetes mellitus |
| KEGG:00520 | 0.000160943997529 | 1.0 | HK2 HK3 | Amino sugar and nucleotide sugar metabolism |
| WP:WP500 | 0.00028347425416 | 1.0 | HK2 HK3 | Glycogen synthesis and degradation |
| KEGG:00010 | 0.000307419292249 | 1.0 | HK2 HK3 | Glycolysis / Gluconeogenesis |
| KEGG:05230 | 0.000359441594481 | 1.0 | HK2 HK3 | Central carbon metabolism in cancer |
| WP:WP534 | 0.00036647347272 | 1.0 | HK2 HK3 | Glycolysis and gluconeogenesis |
| KEGG:04066 | 0.00078862558789 | 1.0 | HK2 HK3 | HIF-1 signaling pathway |
| KEGG:01200 | 0.000870723283599 | 1.0 | HK2 HK3 | Carbon metabolism |
| WP:WP4018 | 0.00118114272566 | 1.0 | HK2 HK3 | Clear cell renal cell carcinoma pathways |
| KEGG:04910 | 0.00128023634398 | 1.0 | HK2 HK3 | Insulin signaling pathway |
| WP:WP5355 | 0.00155570330173 | 1.0 | HK2 HK3 | Metabolic Epileptic Disorders |
| REAC:R-HSA-70171 | 0.00355422444443 | 1.0 | HK2 HK3 | Glycolysis |
| KEGG:05131 | 0.00417007523294 | 1.0 | HK2 HK3 | Shigellosis |
| GO:0004396 | 0.00468200720083 | 1.0 | HK2 HK3 | hexokinase activity |
| GO:0004340 | 0.00468200720083 | 1.0 | HK2 HK3 | glucokinase activity |
| GO:0008865 | 0.00468200720083 | 1.0 | HK2 HK3 | fructokinase activity |
| REAC:R-HSA-70326 | 0.00526469495831 | 1.0 | HK2 HK3 | Glucose metabolism |
| GO:0006002 | 0.0210690324038 | 1.0 | HK2 HK3 | fructose 6-phosphate metabolic process |
| GO:0046835 | 0.0210690324038 | 1.0 | HK2 HK3 | carbohydrate phosphorylation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| HK3 | HK2 | 0.998 | 0.132 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
Related Complexes