hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_02069.1

Complex Portal: CPX-15104

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
CBLL2	E3 ubiquitin-protein ligase CBLL2 (EC 2.3.2.27) (Cbl proto-oncogene-like protein 2) (RING-type E3 ubiquitin transferase ZNF645) (Zinc finger protein 645) (c-Cbl-like protein 2)	5	UniProt NCBI
UBXN11	UBX domain-containing protein 11 (Colorectal tumor-associated antigen COA-1) (Socius) (UBX domain-containing protein 5)	5	UniProt NCBI
COL1A1	Collagen alpha-1(I) chain (Alpha-1 type I collagen)	5	UniProt NCBI
COL1A2	Collagen alpha-2(I) chain (Alpha-2 type I collagen)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
HP:0003321	3.34429085774e-05	0.5	COL1A1 COL1A2	Biconcave flattened vertebrae
HP:0005005	3.34429085774e-05	0.5	COL1A1 COL1A2	Femoral bowing present at birth, straightening with time
HP:0005623	3.34429085774e-05	0.5	COL1A1 COL1A2	Absent ossification of calvaria
HP:0005897	3.34429085774e-05	0.5	COL1A1 COL1A2	Severe generalized osteoporosis
HP:0003023	0.000200620835246	0.5	COL1A1 COL1A2	Bowing of limbs due to multiple fractures
HP:0005758	0.000334337547576	0.5	COL1A1 COL1A2	Basilar impression
HP:0000362	0.000334337547576	0.5	COL1A1 COL1A2	Otosclerosis
REAC:R-HSA-430116	0.000368856835097	0.5	COL1A1 COL1A2	GP1b-IX-V activation signalling
REAC:R-HSA-75892	0.000461028962628	0.5	COL1A1 COL1A2	Platelet Adhesion to exposed collagen
HP:0006367	0.000501460556964	0.5	COL1A1 COL1A2	Crumpled long bones
WP:WP453	0.000644879603036	0.5	COL1A1 COL1A2	Inflammatory response pathway
HP:0000923	0.000701980712879	0.5	COL1A1 COL1A2	Beaded ribs
WP:WP5036	0.00070344077777	0.5	COL1A1 COL1A2	Angiotensin II receptor type 1 pathway
REAC:R-HSA-2214320	0.000798898068561	0.5	COL1A1 COL1A2	Anchoring fibril formation
HP:0025019	0.000935888865729	0.5	COL1A1 COL1A2	Arterial rupture
WP:WP4786	0.0011843872874	0.5	COL1A1 COL1A2	Type I collagen synthesis in the context of osteogenesis imperfecta
HP:0008921	0.00120317586686	0.5	COL1A1 COL1A2	Neonatal short-limb short stature
REAC:R-HSA-2243919	0.00122873738811	0.5	COL1A1 COL1A2	Crosslinking of collagen fibrils
REAC:R-HSA-3000480	0.0013924419067	0.5	COL1A1 COL1A2	Scavenging by Class A Receptors
HP:0031869	0.00183784982408	0.5	COL1A1 COL1A2	Recurrent joint dislocation
HP:0008628	0.00183784982408	0.5	COL1A1 COL1A2	Abnormality of the stapes
HP:0003179	0.00220521848756	0.5	COL1A1 COL1A2	Protrusio acetabuli
HP:0001027	0.00220521848756	0.5	COL1A1 COL1A2	Soft, doughy skin
REAC:R-HSA-3000170	0.00236402400204	0.5	COL1A1 COL1A2	Syndecan interactions
HP:0010547	0.00260592941411	0.5	COL1A1 COL1A2	Muscle flaccidity
WP:WP5144	0.0027493593259	0.5	COL1A1 COL1A2	NRP1 triggered signaling pathways in pancreatic cancer
GO:0005584	0.0028092043205	0.5	COL1A1 COL1A2	collagen type I trimer
REAC:R-HSA-8874081	0.00282403231951	0.5	COL1A1 COL1A2	MET activates PTK2 signaling
HP:0003834	0.00350734148159	0.5	COL1A1 COL1A2	Shoulder dislocation
REAC:R-HSA-114604	0.00359044851421	0.5	COL1A1 COL1A2	GPVI-mediated activation cascade
REAC:R-HSA-76009	0.00386628370571	0.5	COL1A1 COL1A2	Platelet Aggregation (Plug Formation)
WP:WP5055	0.00405547408869	0.5	COL1A1 COL1A2	Burn wound healing
REAC:R-HSA-8948216	0.00444848198459	0.5	COL1A1 COL1A2	Collagen chain trimerization
HP:0005474	0.00454201288615	0.5	COL1A1 COL1A2	Decreased calvarial ossification
HP:0005855	0.00454201288615	0.5	COL1A1 COL1A2	Multiple prenatal fractures
HP:0002691	0.00454201288615	0.5	COL1A1 COL1A2	Platybasia
HP:0040160	0.00454201288615	0.5	COL1A1 COL1A2	Generalized osteoporosis
HP:0100541	0.00454201288615	0.5	COL1A1 COL1A2	Femoral hernia
HP:0000703	0.0051092979876	0.5	COL1A1 COL1A2	Dentinogenesis imperfecta
HP:0004452	0.0051092979876	0.5	COL1A1 COL1A2	Abnormality of the middle ear ossicles
KEGG:04512	0.00551283411821	0.5	COL1A1 COL1A2	ECM-receptor interaction
REAC:R-HSA-8875878	0.00573491177379	0.5	COL1A1 COL1A2	MET promotes cell motility
KEGG:04974	0.00584836845565	0.5	COL1A1 COL1A2	Protein digestion and absorption
REAC:R-HSA-2173782	0.006081926491	0.5	COL1A1 COL1A2	Binding and Uptake of Ligands by Scavenger Receptors
HP:0010299	0.00634372129255	0.5	COL1A1 COL1A2	Abnormal dentin morphology
HP:0010444	0.00844485194452	0.5	COL1A1 COL1A2	Pulmonary insufficiency
HP:0010648	0.00844485194452	0.5	COL1A1 COL1A2	Dermal translucency
KEGG:05146	0.00909742323246	0.5	COL1A1 COL1A2	Amoebiasis
HP:0004586	0.0092117244708	0.5	COL1A1 COL1A2	Biconcave vertebral bodies
KEGG:04933	0.00931062778609	0.5	COL1A1 COL1A2	AGE-RAGE signaling pathway in diabetic complications
HP:0008609	0.0108451581837	0.5	COL1A1 COL1A2	Abnormal middle ear morphology
HP:0001591	0.0108451581837	0.5	COL1A1 COL1A2	Bell-shaped thorax
REAC:R-HSA-2022090	0.0110375739361	0.5	COL1A1 COL1A2	Assembly of collagen fibrils and other multimeric structures
REAC:R-HSA-3000171	0.0115164156767	0.5	COL1A1 COL1A2	Non-integrin membrane-ECM interactions
HP:0032153	0.0117117011059	0.5	COL1A1 COL1A2	Joint subluxation
KEGG:04611	0.0118173906169	0.5	COL1A1 COL1A2	Platelet activation
REAC:R-HSA-1442490	0.0120053783973	0.5	COL1A1 COL1A2	Collagen degradation
HP:0002982	0.0126114492305	0.5	COL1A1 COL1A2	Tibial bowing
HP:0005743	0.0126114492305	0.5	COL1A1 COL1A2	Avascular necrosis of the capital femoral epiphysis
REAC:R-HSA-1650814	0.0135329645116	0.5	COL1A1 COL1A2	Collagen biosynthesis and modifying enzymes
KEGG:04926	0.014352694406	0.5	COL1A1 COL1A2	Relaxin signaling pathway
HP:0001030	0.0155098335254	0.5	COL1A1 COL1A2	Fragile skin
REAC:R-HSA-3000178	0.0168610262513	0.5	COL1A1 COL1A2	ECM proteoglycans
HP:0001075	0.0176079483787	0.5	COL1A1 COL1A2	Atrophic scars
HP:0000015	0.0176079483787	0.5	COL1A1 COL1A2	Bladder diverticulum
HP:0000977	0.018706736024	0.5	COL1A1 COL1A2	Soft skin
REAC:R-HSA-216083	0.0199119958937	0.5	COL1A1 COL1A2	Integrin cell surface interactions
HP:0004331	0.0222019103471	0.5	COL1A1 COL1A2	Decreased skull ossification
HP:0001058	0.0222019103471	0.5	COL1A1 COL1A2	Poor wound healing
HP:0006094	0.0222019103471	0.5	COL1A1 COL1A2	Finger joint hypermobility
HP:0002980	0.0234332085093	0.5	COL1A1 COL1A2	Femoral bowing
HP:0100323	0.0234332085093	0.5	COL1A1 COL1A2	Juvenile aseptic necrosis
REAC:R-HSA-6806834	0.0239057396727	0.5	COL1A1 COL1A2	Signaling by MET
HP:0010529	0.0246976114972	0.5	COL1A1 COL1A2	Echolalia
REAC:R-HSA-1474290	0.0260384914588	0.5	COL1A1 COL1A2	Collagen formation
HP:4000072	0.0273256954732	0.5	COL1A1 COL1A2	Abnormal language feature
HP:0006256	0.0273256954732	0.5	COL1A1 COL1A2	Abnormality of hand joint mobility
HP:4000074	0.0273256954732	0.5	COL1A1 COL1A2	Idiosyncratic language
HP:0002703	0.0315158796726	0.5	COL1A1 COL1A2	Abnormality of skull ossification
HP:0003100	0.0315158796726	0.5	COL1A1 COL1A2	Slender long bone
HP:0000883	0.0329787201379	0.5	COL1A1 COL1A2	Thin ribs
HP:0001623	0.034474601612	0.5	COL1A1 COL1A2	Breech presentation
KEGG:04510	0.03673756538	0.5	COL1A1 COL1A2	Focal adhesion
WP:WP306	0.0374055211141	0.5	COL1A1 COL1A2	Focal adhesion
HP:0430046	0.0375654511359	0.5	COL1A1 COL1A2	Small joint hypermobilty
KEGG:05205	0.0406374666322	0.5	COL1A1 COL1A2	Proteoglycans in cancer
KEGG:05415	0.0406374666322	0.5	COL1A1 COL1A2	Diabetic cardiomyopathy
HP:0002300	0.040788355352	0.5	COL1A1 COL1A2	Mutism
HP:0002812	0.0441432413831	0.5	COL1A1 COL1A2	Coxa vara
HP:0002645	0.0441432413831	0.5	COL1A1 COL1A2	Wormian bones
REAC:R-HSA-198933	0.0473231872721	0.5	COL1A1 COL1A2	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
HP:0001001	0.049422876951	0.5	COL1A1 COL1A2	Abnormality of subcutaneous fat tissue
CORUM:3059	0.049938562206	0.25	COL1A1	ITGA11-ITGB1-COL1A1 complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
COL1A1	COL1A2	0.998	0.616	bioplex_WMM bioplex3_WMM boldt boldt_WMM treiber_WMM WMM_only
CBLL2	COL1A2	0.993		bioplex3_WMM bioplex3_HCT116 WMM_only
UBXN11	COL1A1	0.972		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
CBLL2	COL1A1	0.962		bioplex3_WMM bioplex3_HCT116 WMM_only

Related Complexes

Genename	Complexes
CBLL2	huMAP3_02069.1 huMAP3_02442.1 huMAP3_05851.1 huMAP3_06460.1 huMAP3_07814.1 huMAP3_08727.1 huMAP3_09523.1 huMAP3_09601.1 huMAP3_09606.1 huMAP3_09722.1 huMAP3_10021.1 huMAP3_10401.1 huMAP3_10652.1 huMAP3_12733.1 huMAP3_13681.1 huMAP3_14070.1
UBXN11	huMAP3_02069.1 huMAP3_02141.1 huMAP3_04848.1 huMAP3_09231.1 huMAP3_10652.1 huMAP3_10780.1 huMAP3_14070.1
COL1A1	huMAP3_02069.1 huMAP3_02141.1 huMAP3_06460.1 huMAP3_07562.1 huMAP3_09231.1 huMAP3_09523.1 huMAP3_09606.1 huMAP3_10652.1 huMAP3_10780.1 huMAP3_14070.1
COL1A2	huMAP3_02069.1 huMAP3_02141.1 huMAP3_06460.1 huMAP3_07562.1 huMAP3_09231.1 huMAP3_09523.1 huMAP3_09606.1 huMAP3_10652.1 huMAP3_10780.1 huMAP3_14070.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_02069.1

Complex Portal: CPX-15104