hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_02071.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NSUN5 | 28S rRNA (cytosine-C(5))-methyltransferase (EC 2.1.1.-) (NOL1-related protein) (NOL1R) (NOL1/NOP2/Sun domain family member 5) (Williams-Beuren syndrome chromosomal region 20A protein) | 5 | UniProt NCBI |
| PYCR2 | Pyrroline-5-carboxylate reductase 2 (P5C reductase 2) (P5CR 2) (EC 1.5.1.2) | 5 | UniProt NCBI |
| PYCR1 | Pyrroline-5-carboxylate reductase 1, mitochondrial (P5C reductase 1) (P5CR 1) (EC 1.5.1.2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8964539 | 0.000374861161166 | 0.666666666667 | PYCR2 PYCR1 | Glutamate and glutamine metabolism |
| KEGG:00330 | 0.000688034410789 | 0.666666666667 | PYCR2 PYCR1 | Arginine and proline metabolism |
| WP:WP4290 | 0.000837946224705 | 0.666666666667 | PYCR2 PYCR1 | Metabolic reprogramming in colon cancer |
| KEGG:01230 | 0.00168280767129 | 0.666666666667 | PYCR2 PYCR1 | Biosynthesis of amino acids |
| GO:0004735 | 0.00842684400117 | 0.666666666667 | PYCR2 PYCR1 | pyrroline-5-carboxylate reductase activity |
| GO:0055129 | 0.00842684400117 | 0.666666666667 | PYCR2 PYCR1 | L-proline biosynthetic process |
| GO:0006561 | 0.0140440992017 | 0.666666666667 | PYCR2 PYCR1 | proline biosynthetic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PYCR2 | PYCR1 | 1.0 | 0.416 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| NSUN5 | PYCR2 | 0.958 | 0.08 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only treiber_WMM |
| NSUN5 | PYCR1 | 0.934 | 0.08 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only treiber_WMM |
Related Complexes