hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02073.1
Complex Portal: CPX-24501
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| KLHL24 | Kelch-like protein 24 (Kainate receptor-interacting protein for GluR6) (KRIP6) (Protein DRE1) | 5 | UniProt NCBI |
| KLHL13 | Kelch-like protein 13 (BTB and kelch domain-containing protein 2) | 5 | UniProt NCBI |
| KCTD20 | BTB/POZ domain-containing protein KCTD20 (Potassium channel tetramerization domain containing 20) | 3 | UniProt NCBI |
| BTBD10 | BTB/POZ domain-containing protein 10 (Glucose metabolism-related protein 1) | 4 | UniProt NCBI |
| KLHL18 | Kelch-like protein 18 | 4 | UniProt NCBI |
| KLHL42 | Kelch-like protein 42 (Cullin-3-binding protein 9) (Ctb9) (Kelch domain-containing protein 5) | 5 | UniProt NCBI |
| CUL3 | Cullin-3 (CUL-3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7533 | 2.05265451394e-05 | 0.285714285714 | CUL3 KLHL42 | Ubiquitin E3 ligase (CUL3, KLHL42) |
| CORUM:7525 | 6.1565588648e-05 | 0.285714285714 | KLHL24 CUL3 | Ubiquitin E3 ligase (CUL3, KLHL24, RBX1) |
| GO:0031463 | 7.53137668044e-05 | 0.571428571429 | KLHL24 KLHL42 CUL3 KLHL13 | Cul3-RING ubiquitin ligase complex |
| CORUM:7523 | 0.000123103089524 | 0.285714285714 | KLHL13 CUL3 | Ubiquitin E3 ligase (CUL3, KLHL9, KLHL13, RBX1) |
| REAC:R-HSA-8951664 | 0.0233324089042 | 0.428571428571 | KLHL13 KLHL42 CUL3 | Neddylation |
| GO:0031461 | 0.0293914725345 | 0.571428571429 | KLHL24 KLHL42 CUL3 KLHL13 | cullin-RING ubiquitin ligase complex |
| REAC:R-HSA-983168 | 0.045519996482 | 0.428571428571 | KLHL13 KLHL42 CUL3 | Antigen processing: Ubiquitination & Proteasome degradation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| KLHL42 | CUL3 | 0.998 | 0.178 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| KLHL13 | CUL3 | 0.996 | 0.176230769231 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| KLHL24 | CUL3 | 0.991 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () | |
| KCTD20 | BTBD10 | 0.987 | 0.09 |
mutually_exclusive (Q13618)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| KCTD20 | CUL3 | 0.987 | 0.186 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| KLHL24 | BTBD10 | 0.987 |
mutually_exclusive (Q13618)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| BTBD10 | KLHL42 | 0.986 | 0.1 |
mutually_exclusive (Q13618)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| KLHL24 | KLHL42 | 0.983 |
mutually_exclusive (Q13618)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| BTBD10 | KLHL18 | 0.983 | 0.119 |
mutually_exclusive (Q13618)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| KLHL24 | KLHL18 | 0.983 |
mutually_exclusive (Q13618)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| KCTD20 | KLHL18 | 0.983 | 0.084 |
mutually_exclusive (Q13618)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| BTBD10 | CUL3 | 0.982 | 0.166 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| KLHL24 | KCTD20 | 0.981 |
mutually_exclusive (Q13618)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| KLHL13 | BTBD10 | 0.975 | 0.104 |
mutually_exclusive (Q13618)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| KCTD20 | KLHL42 | 0.975 | 0.11 |
mutually_exclusive (Q13618)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| KLHL18 | KLHL42 | 0.972 | 0.092 |
mutually_exclusive (Q13618)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| KLHL18 | CUL3 | 0.969 | 0.278 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| KLHL13 | KCTD20 | 0.961 | 0.168 |
mutually_exclusive (Q13618)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| KLHL13 | KLHL18 | 0.951 | 0.142 |
mutually_exclusive (Q13618)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| KLHL24 | KLHL13 | 0.894 |
mutually_exclusive (Q13618)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| KLHL13 | KLHL42 | 0.847 | 0.088 |
mutually_exclusive (Q13618)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes