hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_02126.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| BLOC1S4 | Biogenesis of lysosome-related organelles complex 1 subunit 4 (BLOC-1 subunit 4) (Protein cappuccino homolog) | 4 | UniProt NCBI |
| BLOC1S2 | Biogenesis of lysosome-related organelles complex 1 subunit 2 (BLOC-1 subunit 2) (Centrosome-associated protein) | 5 | UniProt NCBI |
| BLOC1S6 | Biogenesis of lysosome-related organelles complex 1 subunit 6 (BLOC-1 subunit 6) (Pallid protein homolog) (Pallidin) (Syntaxin 13-interacting protein) | 5 | UniProt NCBI |
| BLOC1S5 | Biogenesis of lysosome-related organelles complex 1 subunit 5 (BLOC-1 subunit 5) (Protein Muted homolog) | 5 | UniProt NCBI |
| BORCS7 | BLOC-1-related complex subunit 7 (Diaskedin) | 3 | UniProt NCBI |
| BLOC1S3 | Biogenesis of lysosome-related organelles complex 1 subunit 3 (BLOC-1 subunit 3) | 5 | UniProt NCBI |
| DTNBP1 | Dysbindin (Biogenesis of lysosome-related organelles complex 1 subunit 8) (BLOC-1 subunit 8) (Dysbindin-1) (Dystrobrevin-binding protein 1) (Hermansky-Pudlak syndrome 7 protein) (HPS7 protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:23 | 1.51295136123e-18 | 0.857142857143 | DTNBP1 BLOC1S2 BLOC1S5 BLOC1S6 BLOC1S4 BLOC1S3 | BLOC-1 (biogenesis of lysosome-related organelles complex 1) |
| CORUM:654 | 2.49593029159e-17 | 0.857142857143 | DTNBP1 BLOC1S2 BLOC1S5 BLOC1S6 BLOC1S4 BLOC1S3 | BLOC1-BLOC2 complex |
| CORUM:652 | 2.70328971504e-16 | 0.857142857143 | DTNBP1 BLOC1S2 BLOC1S5 BLOC1S6 BLOC1S4 BLOC1S3 | AP3-BLOC1 complex |
| GO:0031083 | 1.2948757735e-13 | 0.857142857143 | DTNBP1 BLOC1S2 BLOC1S5 BLOC1S6 BLOC1S4 BLOC1S3 | BLOC-1 complex |
| GO:0048490 | 4.80196613796e-13 | 0.857142857143 | DTNBP1 BLOC1S2 BLOC1S5 BLOC1S6 BLOC1S4 BLOC1S3 | anterograde synaptic vesicle transport |
| GO:0099514 | 4.80196613796e-13 | 0.857142857143 | DTNBP1 BLOC1S2 BLOC1S5 BLOC1S6 BLOC1S4 BLOC1S3 | synaptic vesicle cytoskeletal transport |
| GO:0099517 | 4.80196613796e-13 | 0.857142857143 | DTNBP1 BLOC1S2 BLOC1S5 BLOC1S6 BLOC1S4 BLOC1S3 | synaptic vesicle transport along microtubule |
| GO:0031082 | 7.01784613453e-13 | 0.857142857143 | DTNBP1 BLOC1S2 BLOC1S5 BLOC1S6 BLOC1S4 BLOC1S3 | BLOC complex |
| GO:0072384 | 2.35639924599e-12 | 1.0 | DTNBP1 BORCS7 BLOC1S5 BLOC1S2 BLOC1S6 BLOC1S4 BLOC1S3 | organelle transport along microtubule |
| GO:0048489 | 2.34212799259e-11 | 0.857142857143 | DTNBP1 BLOC1S2 BLOC1S5 BLOC1S6 BLOC1S4 BLOC1S3 | synaptic vesicle transport |
| GO:0048753 | 5.03304585028e-11 | 0.857142857143 | DTNBP1 BLOC1S2 BLOC1S5 BLOC1S6 BLOC1S4 BLOC1S3 | pigment granule organization |
| GO:0032438 | 5.03304585028e-11 | 0.857142857143 | DTNBP1 BLOC1S2 BLOC1S5 BLOC1S6 BLOC1S4 BLOC1S3 | melanosome organization |
| GO:0097479 | 6.00683068035e-11 | 0.857142857143 | DTNBP1 BLOC1S2 BLOC1S5 BLOC1S6 BLOC1S4 BLOC1S3 | synaptic vesicle localization |
| GO:0047496 | 1.16151397783e-10 | 0.857142857143 | DTNBP1 BLOC1S2 BLOC1S5 BLOC1S6 BLOC1S4 BLOC1S3 | vesicle transport along microtubule |
| GO:0008089 | 1.35501997046e-10 | 0.857142857143 | DTNBP1 BLOC1S2 BLOC1S5 BLOC1S6 BLOC1S4 BLOC1S3 | anterograde axonal transport |
| GO:0010970 | 2.58594976163e-10 | 1.0 | DTNBP1 BORCS7 BLOC1S5 BLOC1S2 BLOC1S6 BLOC1S4 BLOC1S3 | transport along microtubule |
| GO:0099111 | 6.00303577729e-10 | 1.0 | DTNBP1 BORCS7 BLOC1S5 BLOC1S2 BLOC1S6 BLOC1S4 BLOC1S3 | microtubule-based transport |
| GO:0098930 | 6.66661439204e-10 | 0.857142857143 | DTNBP1 BLOC1S2 BLOC1S5 BLOC1S6 BLOC1S4 BLOC1S3 | axonal transport |
| GO:0033059 | 7.48249424115e-10 | 0.857142857143 | DTNBP1 BLOC1S2 BLOC1S5 BLOC1S6 BLOC1S4 BLOC1S3 | cellular pigmentation |
| GO:0008088 | 1.29181280378e-09 | 0.857142857143 | DTNBP1 BLOC1S2 BLOC1S5 BLOC1S6 BLOC1S4 BLOC1S3 | axo-dendritic transport |
| GO:0030705 | 1.44189762778e-09 | 1.0 | DTNBP1 BORCS7 BLOC1S5 BLOC1S2 BLOC1S6 BLOC1S4 BLOC1S3 | cytoskeleton-dependent intracellular transport |
| GO:0099518 | 1.7529090922e-09 | 0.857142857143 | DTNBP1 BLOC1S2 BLOC1S5 BLOC1S6 BLOC1S4 BLOC1S3 | vesicle cytoskeletal trafficking |
| GO:0043473 | 4.38914645297e-09 | 0.857142857143 | DTNBP1 BLOC1S2 BLOC1S5 BLOC1S6 BLOC1S4 BLOC1S3 | pigmentation |
| GO:0007018 | 3.49028820029e-08 | 1.0 | DTNBP1 BORCS7 BLOC1S5 BLOC1S2 BLOC1S6 BLOC1S4 BLOC1S3 | microtubule-based movement |
| HP:0001107 | 9.31603571786e-08 | 0.571428571429 | BLOC1S6 DTNBP1 BLOC1S5 BLOC1S3 | Ocular albinism |
| GO:0051656 | 2.97622789789e-07 | 1.0 | DTNBP1 BORCS7 BLOC1S5 BLOC1S2 BLOC1S6 BLOC1S4 BLOC1S3 | establishment of organelle localization |
| HP:0030402 | 4.88968098733e-07 | 0.571428571429 | BLOC1S6 DTNBP1 BLOC1S5 BLOC1S3 | Abnormal platelet aggregation |
| GO:0051650 | 7.31513734074e-07 | 0.857142857143 | DTNBP1 BLOC1S2 BLOC1S5 BLOC1S6 BLOC1S4 BLOC1S3 | establishment of vesicle localization |
| GO:0051648 | 9.05470698191e-07 | 0.857142857143 | DTNBP1 BLOC1S2 BLOC1S5 BLOC1S6 BLOC1S4 BLOC1S3 | vesicle localization |
| REAC:R-HSA-432722 | 1.11962601005e-06 | 0.571428571429 | BLOC1S4 DTNBP1 BLOC1S3 BLOC1S6 | Golgi Associated Vesicle Biogenesis |
| GO:0051640 | 1.67755128319e-06 | 1.0 | DTNBP1 BORCS7 BLOC1S5 BLOC1S2 BLOC1S6 BLOC1S4 BLOC1S3 | organelle localization |
| HP:0007730 | 2.76451506139e-06 | 0.571428571429 | BLOC1S6 DTNBP1 BLOC1S5 BLOC1S3 | Iris hypopigmentation |
| HP:0011869 | 2.76451506139e-06 | 0.571428571429 | BLOC1S6 DTNBP1 BLOC1S5 BLOC1S3 | Abnormal platelet function |
| REAC:R-HSA-199992 | 3.23754553505e-06 | 0.571428571429 | BLOC1S4 DTNBP1 BLOC1S3 BLOC1S6 | trans-Golgi Network Vesicle Budding |
| GO:0016050 | 1.65028399687e-05 | 0.857142857143 | DTNBP1 BLOC1S2 BLOC1S5 BLOC1S6 BLOC1S4 BLOC1S3 | vesicle organization |
| GO:0007017 | 2.64445381062e-05 | 1.0 | DTNBP1 BORCS7 BLOC1S5 BLOC1S2 BLOC1S6 BLOC1S4 BLOC1S3 | microtubule-based process |
| WP:WP5202 | 3.00494857537e-05 | 0.428571428571 | BLOC1S4 DTNBP1 BLOC1S6 | Alstrom syndrome |
| HP:0001022 | 3.18462612707e-05 | 0.428571428571 | DTNBP1 BLOC1S5 BLOC1S3 | Albinism |
| CORUM:6416 | 6.1565588648e-05 | 0.285714285714 | BLOC1S2 DTNBP1 | dysbindin-Snapin-BLOS2 complex |
| CORUM:6415 | 6.1565588648e-05 | 0.285714285714 | BLOC1S4 BLOC1S6 | pallidin-Cappuccino-BLOS1 complex |
| HP:0000132 | 7.5557211355e-05 | 0.428571428571 | DTNBP1 BLOC1S5 BLOC1S3 | Menorrhagia |
| GO:0140535 | 8.76375670222e-05 | 1.0 | DTNBP1 BORCS7 BLOC1S5 BLOC1S2 BLOC1S6 BLOC1S4 BLOC1S3 | intracellular protein-containing complex |
| HP:0008034 | 0.000130074791482 | 0.571428571429 | BLOC1S6 DTNBP1 BLOC1S5 BLOC1S3 | Abnormal iris pigmentation |
| HP:0007513 | 0.000147554136555 | 0.428571428571 | DTNBP1 BLOC1S5 BLOC1S3 | Generalized hypopigmentation |
| HP:0003540 | 0.00020724248776 | 0.428571428571 | DTNBP1 BLOC1S5 BLOC1S3 | Impaired platelet aggregation |
| GO:0048757 | 0.000282244947588 | 0.428571428571 | BLOC1S6 BLOC1S5 BLOC1S3 | pigment granule maturation |
| GO:0035646 | 0.000282244947588 | 0.428571428571 | BLOC1S6 BLOC1S5 BLOC1S3 | endosome to melanosome transport |
| GO:0043485 | 0.000282244947588 | 0.428571428571 | BLOC1S6 BLOC1S5 BLOC1S3 | endosome to pigment granule transport |
| GO:0043482 | 0.000554182028596 | 0.428571428571 | BLOC1S6 BLOC1S5 BLOC1S3 | cellular pigment accumulation |
| GO:0043476 | 0.000554182028596 | 0.428571428571 | BLOC1S6 BLOC1S5 BLOC1S3 | pigment accumulation |
| CORUM:7545 | 0.000573957048441 | 0.285714285714 | BLOC1S2 BORCS7 | BORC complex |
| GO:0046907 | 0.000594741825979 | 1.0 | DTNBP1 BORCS7 BLOC1S5 BLOC1S2 BLOC1S6 BLOC1S4 BLOC1S3 | intracellular transport |
| HP:0001010 | 0.000715664327131 | 0.571428571429 | BLOC1S6 DTNBP1 BLOC1S5 BLOC1S3 | Hypopigmentation of the skin |
| GO:0031175 | 0.00101122046987 | 0.857142857143 | DTNBP1 BLOC1S2 BLOC1S5 BLOC1S6 BLOC1S4 BLOC1S3 | neuron projection development |
| GO:0048666 | 0.00170914299709 | 0.857142857143 | DTNBP1 BLOC1S2 BLOC1S5 BLOC1S6 BLOC1S4 BLOC1S3 | neuron development |
| GO:0051904 | 0.00228108846854 | 0.428571428571 | BLOC1S6 BLOC1S5 BLOC1S3 | pigment granule transport |
| GO:0032402 | 0.00228108846854 | 0.428571428571 | BLOC1S6 BLOC1S5 BLOC1S3 | melanosome transport |
| GO:0032401 | 0.00273674384085 | 0.428571428571 | BLOC1S6 BLOC1S5 BLOC1S3 | establishment of melanosome localization |
| GO:0051905 | 0.00273674384085 | 0.428571428571 | BLOC1S6 BLOC1S5 BLOC1S3 | establishment of pigment granule localization |
| GO:0051649 | 0.00341941525307 | 1.0 | DTNBP1 BORCS7 BLOC1S5 BLOC1S2 BLOC1S6 BLOC1S4 BLOC1S3 | establishment of localization in cell |
| GO:0051875 | 0.00382182132582 | 0.428571428571 | BLOC1S6 BLOC1S5 BLOC1S3 | pigment granule localization |
| GO:0032400 | 0.00382182132582 | 0.428571428571 | BLOC1S6 BLOC1S5 BLOC1S3 | melanosome localization |
| HP:0000421 | 0.00427148998932 | 0.428571428571 | DTNBP1 BLOC1S5 BLOC1S3 | Epistaxis |
| GO:0050931 | 0.00445787546995 | 0.428571428571 | BLOC1S6 BLOC1S5 BLOC1S3 | pigment cell differentiation |
| GO:0060155 | 0.00445787546995 | 0.428571428571 | DTNBP1 BLOC1S2 BLOC1S3 | platelet dense granule organization |
| HP:0005599 | 0.00496834231452 | 0.428571428571 | DTNBP1 BLOC1S5 BLOC1S3 | Hypopigmentation of hair |
| GO:0030182 | 0.00540289831974 | 0.857142857143 | DTNBP1 BLOC1S2 BLOC1S5 BLOC1S6 BLOC1S4 BLOC1S3 | neuron differentiation |
| HP:0012805 | 0.00598974417902 | 0.285714285714 | BLOC1S5 BLOC1S3 | Iris transillumination defect |
| GO:0048699 | 0.00752325691231 | 0.857142857143 | DTNBP1 BLOC1S2 BLOC1S5 BLOC1S6 BLOC1S4 BLOC1S3 | generation of neurons |
| HP:0009887 | 0.00931276773117 | 0.428571428571 | DTNBP1 BLOC1S5 BLOC1S3 | Abnormality of hair pigmentation |
| GO:0048066 | 0.0109646664486 | 0.428571428571 | BLOC1S6 BLOC1S5 BLOC1S3 | developmental pigmentation |
| HP:0000525 | 0.0140382017336 | 0.571428571429 | BLOC1S6 DTNBP1 BLOC1S5 BLOC1S3 | Abnormality iris morphology |
| REAC:R-HSA-199991 | 0.0144304646027 | 0.571428571429 | BLOC1S4 DTNBP1 BLOC1S3 BLOC1S6 | Membrane Trafficking |
| HP:0001872 | 0.0155103437855 | 0.571428571429 | BLOC1S6 DTNBP1 BLOC1S5 BLOC1S3 | Abnormality of thrombocytes |
| GO:0022008 | 0.0168813694352 | 0.857142857143 | DTNBP1 BLOC1S2 BLOC1S5 BLOC1S6 BLOC1S4 BLOC1S3 | neurogenesis |
| REAC:R-HSA-5653656 | 0.0178473234243 | 0.571428571429 | BLOC1S4 DTNBP1 BLOC1S3 BLOC1S6 | Vesicle-mediated transport |
| HP:0001000 | 0.0189709720562 | 0.571428571429 | BLOC1S6 DTNBP1 BLOC1S5 BLOC1S3 | Abnormality of skin pigmentation |
| GO:0120036 | 0.0268095067638 | 0.857142857143 | DTNBP1 BLOC1S2 BLOC1S5 BLOC1S6 BLOC1S4 BLOC1S3 | plasma membrane bounded cell projection organization |
| GO:0033363 | 0.0281770340738 | 0.428571428571 | DTNBP1 BLOC1S2 BLOC1S3 | secretory granule organization |
| GO:0030030 | 0.0290357560482 | 0.857142857143 | DTNBP1 BLOC1S2 BLOC1S5 BLOC1S6 BLOC1S4 BLOC1S3 | cell projection organization |
| HP:0000978 | 0.0292982733881 | 0.428571428571 | DTNBP1 BLOC1S5 BLOC1S3 | Bruising susceptibility |
| GO:0048087 | 0.0294899169624 | 0.285714285714 | BLOC1S6 BLOC1S5 | positive regulation of developmental pigmentation |
| GO:0050932 | 0.0294899169624 | 0.285714285714 | BLOC1S6 BLOC1S5 | regulation of pigment cell differentiation |
| GO:0050942 | 0.0294899169624 | 0.285714285714 | BLOC1S6 BLOC1S5 | positive regulation of pigment cell differentiation |
| HP:0007750 | 0.0348446257606 | 0.285714285714 | BLOC1S5 BLOC1S3 | Hypoplasia of the fovea |
| HP:0008060 | 0.0348446257606 | 0.285714285714 | BLOC1S5 BLOC1S3 | Aplasia/Hypoplasia of the fovea |
| HP:0000553 | 0.0355505847959 | 0.571428571429 | BLOC1S6 DTNBP1 BLOC1S5 BLOC1S3 | Abnormal uvea morphology |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| BLOC1S2 | DTNBP1 | 1.0 | 0.158 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
| BLOC1S5 | DTNBP1 | 1.0 | 0.844 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| BLOC1S4 | DTNBP1 | 1.0 | 0.354 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM |
| BLOC1S3 | DTNBP1 | 1.0 | 0.136 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
| BLOC1S6 | DTNBP1 | 1.0 | 0.186 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| BLOC1S2 | BLOC1S5 | 0.999 | 0.376 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| BLOC1S6 | BLOC1S3 | 0.999 | 0.248 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| BLOC1S6 | BLOC1S5 | 0.999 | 0.552 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| BLOC1S5 | BLOC1S3 | 0.999 | 0.34 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| BLOC1S4 | BLOC1S5 | 0.999 | 0.42 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| BLOC1S4 | BLOC1S6 | 0.998 | 0.334 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| BLOC1S2 | BORCS7 | 0.997 | 0.278 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM WMM_only |
| BLOC1S2 | BLOC1S6 | 0.994 | 0.132 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| BLOC1S4 | BLOC1S2 | 0.994 | 0.304 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM |
| BLOC1S4 | BORCS7 | 0.99 | 0.118 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| BLOC1S6 | BORCS7 | 0.989 | 0.086 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| BLOC1S4 | BLOC1S3 | 0.987 | 0.18 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM |
| BORCS7 | DTNBP1 | 0.986 | 0.232 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM |
| BLOC1S2 | BLOC1S3 | 0.976 | 0.376 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| BLOC1S5 | BORCS7 | 0.963 | 0.44 | bioplex_WMM bioplex3_WMM WMM_only |
| BORCS7 | BLOC1S3 | 0.6 | 0.332 | bioplex3_WMM WMM_only |
Related Complexes