hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02170.1
Complex Portal: CPX-11548
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DBF4 | Protein DBF4 homolog A (Activator of S phase kinase) (Chiffon homolog A) (DBF4-type zinc finger-containing protein 1) | 5 | UniProt NCBI |
| CDC7 | Cell division cycle 7-related protein kinase (CDC7-related kinase) (HsCdc7) (huCdc7) (EC 2.7.11.1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:947 | 1.70876175213e-06 | 1.0 | CDC7 DBF4 | CDC7-DBF7 complex |
| WP:WP466 | 0.00036647347272 | 1.0 | CDC7 DBF4 | DNA replication |
| REAC:R-HSA-68962 | 0.000902226205124 | 1.0 | CDC7 DBF4 | Activation of the pre-replicative complex |
| REAC:R-HSA-176187 | 0.00107651990384 | 1.0 | CDC7 DBF4 | Activation of ATR in response to replication stress |
| KEGG:04110 | 0.00184110178991 | 1.0 | CDC7 DBF4 | Cell cycle |
| WP:WP179 | 0.00283899891178 | 1.0 | CDC7 DBF4 | Cell cycle |
| GO:0010571 | 0.00702301080125 | 1.0 | CDC7 DBF4 | positive regulation of nuclear cell cycle DNA replication |
| GO:0033262 | 0.0131096201623 | 1.0 | CDC7 DBF4 | regulation of nuclear cell cycle DNA replication |
| REAC:R-HSA-69206 | 0.0143279672916 | 1.0 | CDC7 DBF4 | G1/S Transition |
| REAC:R-HSA-69002 | 0.0183367223621 | 1.0 | CDC7 DBF4 | DNA Replication Pre-Initiation |
| REAC:R-HSA-453279 | 0.0183367223621 | 1.0 | CDC7 DBF4 | Mitotic G1 phase and G1/S transition |
| REAC:R-HSA-69481 | 0.0214637563685 | 1.0 | CDC7 DBF4 | G2/M Checkpoints |
| REAC:R-HSA-69306 | 0.0257185731313 | 1.0 | CDC7 DBF4 | DNA Replication |
| GO:2000105 | 0.0257510396046 | 1.0 | CDC7 DBF4 | positive regulation of DNA-templated DNA replication |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DBF4 | CDC7 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| DBF4 | huMAP3_02170.1 huMAP3_13036.1 |
| CDC7 | huMAP3_02170.1 huMAP3_13036.1 |