hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02172.1
Complex Portal: CPX-16342
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ZNF408 | Zinc finger protein 408 (PR domain zinc finger protein 17) | 5 | UniProt NCBI |
| CDKN2A | Tumor suppressor ARF (Alternative reading frame) (ARF) (Cyclin-dependent kinase inhibitor 2A) (p14ARF) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9646303 | 0.0249718442457 | 0.5 | CDKN2A | Evasion of Oncogene Induced Senescence Due to p14ARF Defects |
| REAC:R-HSA-9646304 | 0.0249718442457 | 0.5 | CDKN2A | Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects |
| CORUM:1642 | 0.0249718442457 | 0.5 | CDKN2A | p16-cyclin D2-CDK4 complex |
| REAC:R-HSA-9645722 | 0.0499419797295 | 0.5 | CDKN2A | Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function |
| REAC:R-HSA-9630791 | 0.0499419797295 | 0.5 | CDKN2A | Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 |
| REAC:R-HSA-9632697 | 0.0499419797295 | 0.5 | CDKN2A | Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CDKN2A | ZNF408 | 0.98 | hein_WMM bioplex3_HEK293 bioplex () bioplex3_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| ZNF408 | huMAP3_02172.1 huMAP3_12377.1 huMAP3_13566.1 huMAP3_14892.1 |
| CDKN2A | huMAP3_01523.1 huMAP3_02172.1 huMAP3_09622.1 huMAP3_10449.1 huMAP3_14722.1 huMAP3_14892.1 |