hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02184.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TNRC6B | Trinucleotide repeat-containing gene 6B protein | 5 | UniProt NCBI |
| AGO3 | Protein argonaute-3 (Argonaute3) (hAgo3) (EC 3.1.26.n2) (Argonaute RISC catalytic component 3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3) | 5 | UniProt NCBI |
| AGO4 | Protein argonaute-4 (Argonaute4) (hAgo4) (Argonaute RISC catalytic component 4) (Eukaryotic translation initiation factor 2C 4) (eIF-2C 4) (eIF2C 4) | 5 | UniProt NCBI |
| TNRC6A | Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-426496 | 3.36110250117e-12 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | Post-transcriptional silencing by small RNAs |
| REAC:R-HSA-9768778 | 6.72220500234e-12 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | Regulation of NPAS4 mRNA translation |
| REAC:R-HSA-8948700 | 6.72220500234e-12 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation |
| REAC:R-HSA-8943723 | 1.20999690042e-11 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | Regulation of PTEN mRNA translation |
| REAC:R-HSA-9768759 | 2.0166615007e-11 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | Regulation of NPAS4 gene expression |
| REAC:R-HSA-8934593 | 2.2855497008e-10 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | Regulation of RUNX1 Expression and Activity |
| REAC:R-HSA-9634815 | 1.96624496318e-09 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | Transcriptional Regulation by NPAS4 |
| REAC:R-HSA-9022692 | 2.28084415729e-09 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | Regulation of MECP2 expression and activity |
| REAC:R-HSA-9029569 | 3.02163114855e-09 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux |
| REAC:R-HSA-2559585 | 3.92960898137e-09 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | Oncogene Induced Senescence |
| REAC:R-HSA-8853884 | 6.34240041971e-09 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | Transcriptional Regulation by VENTX |
| REAC:R-HSA-9024446 | 7.89868690925e-09 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | NR1H2 and NR1H3-mediated signaling |
| REAC:R-HSA-8986944 | 2.81204239973e-08 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | Transcriptional Regulation by MECP2 |
| REAC:R-HSA-4086398 | 2.81204239973e-08 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | Ca2+ pathway |
| GO:0035278 | 6.26240618018e-08 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | miRNA-mediated gene silencing by inhibition of translation |
| REAC:R-HSA-1912408 | 1.23206013755e-07 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | Pre-NOTCH Transcription and Translation |
| REAC:R-HSA-5628897 | 1.44287424832e-07 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | TP53 Regulates Metabolic Genes |
| REAC:R-HSA-8936459 | 1.51881499823e-07 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
| REAC:R-HSA-5687128 | 1.59771447866e-07 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | MAPK6/MAPK4 signaling |
| REAC:R-HSA-1912422 | 2.68326895976e-07 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | Pre-NOTCH Expression and Processing |
| REAC:R-HSA-2559580 | 4.95581119387e-07 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | Oxidative Stress Induced Senescence |
| REAC:R-HSA-211000 | 7.36929886059e-07 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | Gene Silencing by RNA |
| REAC:R-HSA-9018519 | 9.92449541033e-07 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | Estrogen-dependent gene expression |
| REAC:R-HSA-6807070 | 1.27076899474e-06 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | PTEN Regulation |
| REAC:R-HSA-3858494 | 1.3092771461e-06 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | Beta-catenin independent WNT signaling |
| GO:0035195 | 3.24724179284e-06 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | miRNA-mediated post-transcriptional gene silencing |
| REAC:R-HSA-2559583 | 3.6254700184e-06 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | Cellular Senescence |
| REAC:R-HSA-8939211 | 4.53643299039e-06 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | ESR-mediated signaling |
| REAC:R-HSA-157118 | 6.727846949e-06 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | Signaling by NOTCH |
| GO:0035194 | 7.70499617526e-06 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | regulatory ncRNA-mediated post-transcriptional gene silencing |
| REAC:R-HSA-8878171 | 7.70750547835e-06 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | Transcriptional regulation by RUNX1 |
| REAC:R-HSA-1257604 | 1.09075319437e-05 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | PIP3 activates AKT signaling |
| GO:0016441 | 1.28309598221e-05 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | post-transcriptional gene silencing |
| REAC:R-HSA-9006931 | 1.45341769075e-05 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | Signaling by Nuclear Receptors |
| REAC:R-HSA-5683057 | 1.50136248309e-05 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | MAPK family signaling cascades |
| REAC:R-HSA-9006925 | 1.92889821679e-05 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | Intracellular signaling by second messengers |
| REAC:R-HSA-195721 | 3.05084383483e-05 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | Signaling by WNT |
| REAC:R-HSA-3700989 | 5.13018653608e-05 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | Transcriptional Regulation by TP53 |
| GO:0031047 | 8.0240394575e-05 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | regulatory ncRNA-mediated gene silencing |
| GO:0017148 | 0.000116335377665 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | negative regulation of translation |
| GO:0016442 | 0.000139871762976 | 0.75 | AGO3 TNRC6A AGO4 | RISC complex |
| GO:0031332 | 0.000139871762976 | 0.75 | AGO3 TNRC6A AGO4 | RNAi effector complex |
| GO:0034249 | 0.000223536588601 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | negative regulation of amide metabolic process |
| REAC:R-HSA-426486 | 0.000368856835097 | 0.5 | AGO3 AGO4 | Small interfering RNA (siRNA) biogenesis |
| REAC:R-HSA-2262752 | 0.00108429068544 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | Cellular responses to stress |
| REAC:R-HSA-8953897 | 0.00112698633356 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | Cellular responses to stimuli |
| GO:0006402 | 0.0018072843765 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | mRNA catabolic process |
| GO:0036464 | 0.00195512544603 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | cytoplasmic ribonucleoprotein granule |
| REAC:R-HSA-203927 | 0.00258893271292 | 0.5 | AGO3 AGO4 | MicroRNA (miRNA) biogenesis |
| GO:0035770 | 0.00268689789642 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | ribonucleoprotein granule |
| GO:0006401 | 0.00404764913615 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | RNA catabolic process |
| REAC:R-HSA-212436 | 0.00439089268099 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | Generic Transcription Pathway |
| GO:0006417 | 0.00544748110584 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | regulation of translation |
| REAC:R-HSA-73857 | 0.00681752083972 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | RNA Polymerase II Transcription |
| GO:0034248 | 0.0105899075134 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | regulation of amide metabolic process |
| REAC:R-HSA-74160 | 0.0112707156575 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | Gene expression (Transcription) |
| CORUM:1386 | 0.0249718442456 | 0.25 | AGO4 | TTP-AGO4 complex |
| GO:0034655 | 0.0252333972666 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | nucleobase-containing compound catabolic process |
| GO:0010608 | 0.0262860281498 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | post-transcriptional regulation of gene expression |
| GO:0046700 | 0.0333098536164 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | heterocycle catabolic process |
| GO:0044270 | 0.0336301406704 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | cellular nitrogen compound catabolic process |
| GO:0019439 | 0.0352663601862 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | aromatic compound catabolic process |
| GO:1901361 | 0.0409056153775 | 1.0 | TNRC6A AGO3 TNRC6B AGO4 | organic cyclic compound catabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TNRC6B | TNRC6A | 0.998 | 0.208 | hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| AGO3 | TNRC6A | 0.996 | 0.166 | hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 |
| TNRC6B | AGO3 | 0.993 | 0.152 | hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 |
| AGO3 | AGO4 | 0.968 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM treiber_WMM WMM_only | |
| AGO4 | TNRC6A | 0.715 | youn () bioplex3_HEK293 bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| TNRC6B | AGO4 | 0.57 | youn () bioplex3_HEK293 bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes