hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_02194.1

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
ITPR2	Inositol 1,4,5-trisphosphate receptor type 2 (IP3 receptor isoform 2) (IP3R 2) (InsP3R2) (Type 2 inositol 1,4,5-trisphosphate receptor) (Type 2 InsP3 receptor)	5	UniProt NCBI
ITPR1	Inositol 1,4,5-trisphosphate receptor type 1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor)	5	UniProt NCBI
IRAG1	Inositol 1,4,5-triphosphate receptor associated 1 (Inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate) (JAW1-related protein MRVI1) (Protein MRVI1)	5	UniProt NCBI
TESPA1	Protein TESPA1 (Thymocyte-expressed positive selection-associated protein 1)	5	UniProt NCBI
ITPR3	Inositol 1,4,5-trisphosphate receptor type 3 (IP3 receptor isoform 3) (IP3R 3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor)	5	UniProt NCBI
BBOX1	Gamma-butyrobetaine dioxygenase (EC 1.14.11.1) (Gamma-butyrobetaine hydroxylase) (Gamma-BBH) (Gamma-butyrobetaine,2-oxoglutarate dioxygenase)	5	UniProt NCBI
BOK	Bcl-2-related ovarian killer protein (hBOK) (Bcl-2-like protein 9) (Bcl2-L-9)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0031095	1.1594342202e-07	0.571428571429	IRAG1 ITPR3 ITPR2 ITPR1	platelet dense tubular network membrane
GO:0031094	3.03561565333e-07	0.571428571429	IRAG1 ITPR3 ITPR2 ITPR1	platelet dense tubular network
REAC:R-HSA-5607763	1.09397266507e-06	0.428571428571	ITPR3 ITPR2 ITPR1	CLEC7A (Dectin-1) induces NFAT activation
REAC:R-HSA-139853	2.86340161093e-06	0.428571428571	ITPR3 ITPR2 ITPR1	Elevation of cytosolic Ca2+ levels
KEGG:04270	3.14544883063e-06	0.571428571429	IRAG1 ITPR3 ITPR2 ITPR1	Vascular smooth muscle contraction
GO:0005220	3.36420143768e-06	0.428571428571	ITPR3 ITPR2 ITPR1	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
REAC:R-HSA-418346	3.63144818167e-06	0.571428571429	IRAG1 ITPR3 ITPR2 ITPR1	Platelet homeostasis
REAC:R-HSA-5218921	4.73568218926e-06	0.428571428571	ITPR3 ITPR2 ITPR1	VEGFR2 mediated cell proliferation
KEGG:04022	9.1325827897e-06	0.571428571429	IRAG1 ITPR3 ITPR2 ITPR1	cGMP-PKG signaling pathway
REAC:R-HSA-2871809	1.25938591632e-05	0.428571428571	ITPR3 ITPR2 ITPR1	FCERI mediated Ca+2 mobilization
REAC:R-HSA-2029485	1.72785870928e-05	0.428571428571	ITPR3 ITPR2 ITPR1	Role of phospholipids in phagocytosis
WP:WP4698	1.77389368121e-05	0.428571428571	ITPR3 ITPR2 ITPR1	Vitamin D sensitive calcium signaling in depression
REAC:R-HSA-983695	2.00026744108e-05	0.428571428571	ITPR3 ITPR2 ITPR1	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
REAC:R-HSA-114508	2.29983491089e-05	0.428571428571	ITPR3 ITPR2 ITPR1	Effects of PIP2 hydrolysis
REAC:R-HSA-418360	2.29983491089e-05	0.428571428571	ITPR3 ITPR2 ITPR1	Platelet calcium homeostasis
WP:WP4756	3.62383476827e-05	0.428571428571	ITPR3 ITPR2 ITPR1	Renin angiotensin aldosterone system RAAS
KEGG:04927	3.99924354203e-05	0.428571428571	ITPR3 ITPR2 ITPR1	Cortisol synthesis and secretion
KEGG:04929	4.94026671671e-05	0.428571428571	ITPR3 ITPR2 ITPR1	GnRH secretion
REAC:R-HSA-9664323	5.26476903505e-05	0.428571428571	ITPR3 ITPR2 ITPR1	FCGR3A-mediated IL10 synthesis
KEGG:04730	6.01790990174e-05	0.428571428571	ITPR3 ITPR2 ITPR1	Long-term depression
KEGG:04924	6.01790990174e-05	0.428571428571	ITPR3 ITPR2 ITPR1	Renin secretion
KEGG:04971	8.14238080924e-05	0.428571428571	ITPR3 ITPR2 ITPR1	Gastric acid secretion
REAC:R-HSA-381676	8.47845144152e-05	0.428571428571	ITPR3 ITPR2 ITPR1	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
KEGG:04720	8.61957069406e-05	0.428571428571	ITPR3 ITPR2 ITPR1	Long-term potentiation
REAC:R-HSA-1489509	9.24731829377e-05	0.428571428571	ITPR3 ITPR2 ITPR1	DAG and IP3 signaling
KEGG:04918	0.000118770256621	0.428571428571	ITPR3 ITPR2 ITPR1	Thyroid hormone synthesis
REAC:R-HSA-5578775	0.000137920329377	0.428571428571	ITPR3 ITPR2 ITPR1	Ion homeostasis
KEGG:04970	0.000144487772681	0.428571428571	ITPR3 ITPR2 ITPR1	Salivary secretion
REAC:R-HSA-112043	0.00014849904315	0.428571428571	ITPR3 ITPR2 ITPR1	PLC beta mediated events
KEGG:04912	0.000173655650743	0.428571428571	ITPR3 ITPR2 ITPR1	GnRH signaling pathway
WP:WP5356	0.00017635857097	0.428571428571	ITPR3 ITPR2 ITPR1	Affected pathways in Duchenne muscular dystrophy
KEGG:04750	0.000181511715818	0.428571428571	ITPR3 ITPR2 ITPR1	Inflammatory mediator regulation of TRP channels
GO:0070679	0.0001882019462	0.428571428571	ITPR3 ITPR2 ITPR1	inositol 1,4,5 trisphosphate binding
KEGG:04540	0.000197924017979	0.428571428571	ITPR3 ITPR2 ITPR1	Gap junction
KEGG:04972	0.000206486888796	0.428571428571	ITPR3 ITPR2 ITPR1	Pancreatic secretion
REAC:R-HSA-112040	0.000209532838622	0.428571428571	ITPR3 ITPR2 ITPR1	G-protein mediated events
KEGG:04925	0.000224342633213	0.428571428571	ITPR3 ITPR2 ITPR1	Aldosterone synthesis and secretion
KEGG:04724	0.000294849715299	0.428571428571	ITPR3 ITPR2 ITPR1	Glutamatergic synapse
REAC:R-HSA-4086398	0.00030234111687	0.428571428571	ITPR3 ITPR2 ITPR1	Ca2+ pathway
KEGG:04928	0.00031739249581	0.428571428571	ITPR3 ITPR2 ITPR1	Parathyroid hormone synthesis, secretion and action
KEGG:04726	0.000329079973498	0.428571428571	ITPR3 ITPR2 ITPR1	Serotonergic synapse
KEGG:04625	0.000341049215895	0.428571428571	ITPR3 ITPR2 ITPR1	C-type lectin receptor signaling pathway
KEGG:04070	0.000341049215895	0.428571428571	ITPR3 ITPR2 ITPR1	Phosphatidylinositol signaling system
KEGG:04725	0.00039180931737	0.428571428571	ITPR3 ITPR2 ITPR1	Cholinergic synapse
KEGG:04922	0.00043299818525	0.428571428571	ITPR3 ITPR2 ITPR1	Glucagon signaling pathway
KEGG:04915	0.00043299818525	0.428571428571	ITPR3 ITPR2 ITPR1	Estrogen signaling pathway
REAC:R-HSA-9664433	0.000487210059522	0.428571428571	ITPR3 ITPR2 ITPR1	Leishmania parasite growth and survival
REAC:R-HSA-9662851	0.000487210059522	0.428571428571	ITPR3 ITPR2 ITPR1	Anti-inflammatory response favouring Leishmania parasite infection
KEGG:04611	0.00052377688541	0.428571428571	ITPR3 ITPR2 ITPR1	Platelet activation
KEGG:04935	0.00055662089629	0.428571428571	ITPR3 ITPR2 ITPR1	Growth hormone synthesis, secretion and action
REAC:R-HSA-422356	0.000562353197014	0.428571428571	ITPR3 ITPR2 ITPR1	Regulation of insulin secretion
KEGG:04114	0.000626340980717	0.428571428571	ITPR3 ITPR2 ITPR1	Oocyte meiosis
KEGG:04728	0.000721317320656	0.428571428571	ITPR3 ITPR2 ITPR1	Dopaminergic synapse
GO:0015278	0.000738757615619	0.428571428571	ITPR3 ITPR2 ITPR1	calcium-release channel activity
KEGG:04371	0.00076182524647	0.428571428571	ITPR3 ITPR2 ITPR1	Apelin signaling pathway
KEGG:04380	0.000847297701863	0.428571428571	ITPR3 ITPR2 ITPR1	Osteoclast differentiation
KEGG:04921	0.000915402267115	0.428571428571	ITPR3 ITPR2 ITPR1	Oxytocin signaling pathway
KEGG:04723	0.000938882748497	0.428571428571	ITPR3 ITPR2 ITPR1	Retrograde endocannabinoid signaling
KEGG:04210	0.000962758015712	0.428571428571	ITPR3 ITPR2 ITPR1	Apoptosis
REAC:R-HSA-2029480	0.000976813602208	0.428571428571	ITPR3 ITPR2 ITPR1	Fcgamma receptor (FCGR) dependent phagocytosis
REAC:R-HSA-111885	0.000976813602208	0.428571428571	ITPR3 ITPR2 ITPR1	Opioid Signalling
KEGG:05017	0.00108816732534	0.428571428571	ITPR3 ITPR2 ITPR1	Spinocerebellar ataxia
KEGG:04934	0.00108816732534	0.428571428571	ITPR3 ITPR2 ITPR1	Cushing syndrome
REAC:R-HSA-5576891	0.00126637654584	0.428571428571	ITPR3 ITPR2 ITPR1	Cardiac conduction
WP:WP536	0.00135826261108	0.428571428571	ITPR3 ITPR2 ITPR1	Calcium regulation in cardiac cells
REAC:R-HSA-4420097	0.00135845178782	0.428571428571	ITPR3 ITPR2 ITPR1	VEGFA-VEGFR2 Pathway
REAC:R-HSA-5607764	0.00150471527401	0.428571428571	ITPR3 ITPR2 ITPR1	CLEC7A (Dectin-1) signaling
KEGG:04218	0.00152804474169	0.428571428571	ITPR3 ITPR2 ITPR1	Cellular senescence
REAC:R-HSA-163685	0.00155569177621	0.428571428571	ITPR3 ITPR2 ITPR1	Integration of energy metabolism
KEGG:04621	0.00173244468583	0.428571428571	ITPR3 ITPR2 ITPR1	NOD-like receptor signaling pathway
REAC:R-HSA-194138	0.00177103051244	0.428571428571	ITPR3 ITPR2 ITPR1	Signaling by VEGF
REAC:R-HSA-983705	0.00182778376728	0.428571428571	ITPR3 ITPR2 ITPR1	Signaling by the B Cell Receptor (BCR)
WP:WP289	0.00217346109793	0.428571428571	ITPR3 ITPR2 ITPR1	Myometrial relaxation and contraction pathways
REAC:R-HSA-418457	0.00250948572249	0.285714285714	ITPR1 IRAG1	cGMP effects
KEGG:05167	0.0026347269947	0.428571428571	ITPR3 ITPR2 ITPR1	Kaposi sarcoma-associated herpesvirus infection
GO:0099604	0.00273674384085	0.428571428571	ITPR3 ITPR2 ITPR1	ligand-gated calcium channel activity
KEGG:04020	0.00282628603843	0.428571428571	ITPR3 ITPR2 ITPR1	Calcium signaling pathway
REAC:R-HSA-2454202	0.00282879296945	0.428571428571	ITPR3 ITPR2 ITPR1	Fc epsilon receptor (FCERI) signaling
KEGG:05205	0.00334477554904	0.428571428571	ITPR3 ITPR2 ITPR1	Proteoglycans in cancer
REAC:R-HSA-5621481	0.00357489216687	0.428571428571	ITPR3 ITPR2 ITPR1	C-type lectin receptors (CLRs)
KEGG:05163	0.00392224047448	0.428571428571	ITPR3 ITPR2 ITPR1	Human cytomegalovirus infection
KEGG:05170	0.0039833462196	0.428571428571	ITPR3 ITPR2 ITPR1	Human immunodeficiency virus 1 infection
GO:0005217	0.00445787546995	0.428571428571	ITPR3 ITPR2 ITPR1	intracellular ligand-gated monoatomic ion channel activity
REAC:R-HSA-416476	0.00465019583743	0.428571428571	ITPR3 ITPR2 ITPR1	G alpha (q) signalling events
REAC:R-HSA-392154	0.00516516478082	0.285714285714	ITPR1 IRAG1	Nitric oxide stimulates guanylate cyclase
REAC:R-HSA-9658195	0.00520230847661	0.428571428571	ITPR3 ITPR2 ITPR1	Leishmania infection
REAC:R-HSA-9824443	0.00520230847661	0.428571428571	ITPR3 ITPR2 ITPR1	Parasitic Infection Pathways
REAC:R-HSA-3858494	0.00520230847661	0.428571428571	ITPR3 ITPR2 ITPR1	Beta-catenin independent WNT signaling
KEGG:05131	0.00645082416518	0.428571428571	ITPR3 ITPR2 ITPR1	Shigellosis
REAC:R-HSA-397014	0.00697432613022	0.428571428571	ITPR3 ITPR2 ITPR1	Muscle contraction
KEGG:05012	0.00742241965355	0.428571428571	ITPR3 ITPR2 ITPR1	Parkinson disease
KEGG:05020	0.00808797926109	0.428571428571	ITPR3 ITPR2 ITPR1	Prion disease
REAC:R-HSA-109582	0.0102424024409	0.571428571429	IRAG1 ITPR3 ITPR2 ITPR1	Hemostasis
WP:WP2059	0.0117907139106	0.428571428571	ITPR3 ITPR2 ITPR1	Alzheimer 39 s disease and miRNA effects
WP:WP5124	0.0117907139106	0.428571428571	ITPR3 ITPR2 ITPR1	Alzheimer 39 s disease
REAC:R-HSA-418594	0.0132505363601	0.428571428571	ITPR3 ITPR2 ITPR1	G alpha (i) signalling events
REAC:R-HSA-76002	0.0209553984355	0.428571428571	ITPR3 ITPR2 ITPR1	Platelet activation, signaling and aggregation
KEGG:05010	0.0212667141862	0.428571428571	ITPR3 ITPR2 ITPR1	Alzheimer disease
GO:0016529	0.0218744047191	0.428571428571	ITPR3 ITPR2 ITPR1	sarcoplasmic reticulum
KEGG:04713	0.0265381810008	0.285714285714	ITPR1 ITPR3	Circadian entrainment
GO:0016528	0.0305188440994	0.428571428571	ITPR3 ITPR2 ITPR1	sarcoplasm
KEGG:05022	0.0378661997772	0.428571428571	ITPR3 ITPR2 ITPR1	Pathways of neurodegeneration - multiple diseases
REAC:R-HSA-9006925	0.0378815015202	0.428571428571	ITPR3 ITPR2 ITPR1	Intracellular signaling by second messengers

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
IRAG1	BOK	1.0		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
ITPR2	ITPR3	0.999	0.174	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
ITPR1	TESPA1	0.999		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TESPA1	BOK	0.999		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
ITPR2	TESPA1	0.998		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
ITPR1	ITPR3	0.998	0.486	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
ITPR1	IRAG1	0.998		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
TESPA1	ITPR3	0.997		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
ITPR2	ITPR1	0.996	0.206	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
BBOX1	BOK	0.996		bioplex3_WMM bioplex3_HCT116 WMM_only
ITPR1	BBOX1	0.996		bioplex3_WMM bioplex3_HCT116 WMM_only
ITPR2	IRAG1	0.996		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
IRAG1	ITPR3	0.993		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
ITPR2	BBOX1	0.992		bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 bioplex_WMM
ITPR3	BBOX1	0.962		bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 bioplex_WMM
ITPR1	BOK	0.961		bioplex_WMM bioplex3_WMM WMM_only
ITPR2	BOK	0.95		bioplex_WMM bioplex3_WMM WMM_only
ITPR3	BOK	0.95		bioplex_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
ITPR2	huMAP3_02194.1 huMAP3_07657.1 huMAP3_07956.1
ITPR1	huMAP3_02194.1 huMAP3_07657.1 huMAP3_07956.1
IRAG1	huMAP3_02194.1 huMAP3_07657.1 huMAP3_07956.1 huMAP3_11808.1
TESPA1	huMAP3_02194.1 huMAP3_07657.1 huMAP3_08965.1 huMAP3_09231.1 huMAP3_09523.1 huMAP3_14070.1
ITPR3	huMAP3_02194.1 huMAP3_07657.1 huMAP3_07689.1 huMAP3_07956.1
BBOX1	huMAP3_02194.1 huMAP3_07956.1 huMAP3_08217.1 huMAP3_12986.1 huMAP3_13879.1 huMAP3_15146.1
BOK	huMAP3_02194.1 huMAP3_07657.1 huMAP3_07956.1 huMAP3_11808.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_02194.1