hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02200.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GFER | FAD-linked sulfhydryl oxidase ALR (EC 1.8.3.2) (Augmenter of liver regeneration) (hERV1) (Hepatopoietin) | 5 | UniProt NCBI |
| AIFM1 | Apoptosis-inducing factor 1, mitochondrial (EC 1.6.99.-) (Programmed cell death protein 8) | 5 | UniProt NCBI |
| AK2 | Adenylate kinase 2, mitochondrial (AK 2) (EC 2.7.4.3) (ATP-AMP transphosphorylase 2) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) [Cleaved into: Adenylate kinase 2, mitochondrial, N-terminally processed] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0003287 | 0.000760279216794 | 1.0 | AIFM1 GFER AK2 | Abnormality of mitochondrial metabolism |
| HP:0012103 | 0.00112027388307 | 1.0 | AIFM1 GFER AK2 | Abnormality of the mitochondrion |
| HP:0011017 | 0.0218534403487 | 1.0 | AIFM1 GFER AK2 | Abnormal cellular physiology |
| HP:0025354 | 0.0250749987795 | 1.0 | AIFM1 GFER AK2 | Abnormal cellular phenotype |
| CORUM:5843 | 0.0499402709677 | 0.333333333333 | AIFM1 | AIF-CYPA-DNA complex |
| CORUM:5856 | 0.0499402709677 | 0.333333333333 | AK2 | AK2-FADD-caspase-10 (AFAC10) complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| AIFM1 | AK2 | 0.999 | 0.47 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 fraction boldt_WMM |
| AIFM1 | GFER | 0.995 | 0.214 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GFER | AK2 | 0.24 | 0.174 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
Related Complexes