hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_02201.1

Complex Portal: CPX-12682

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
SLC17A5	Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular excitatory amino acid transporter) (VEAT)	5	UniProt NCBI
SLC9A6	Sodium/hydrogen exchanger 6 (Na(+)/H(+) exchanger 6) (NHE-6) (Solute carrier family 9 member 6)	5	UniProt NCBI
SLC12A4	Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (hKCC1)	5	UniProt NCBI
LGALS9	Galectin-9 (Gal-9) (Ecalectin) (Tumor antigen HOM-HD-21)	5	UniProt NCBI
ATP2B4	Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4)	5	UniProt NCBI
CD58	Lymphocyte function-associated antigen 3 (Ag3) (Surface glycoprotein LFA-3) (CD antigen CD58)	5	UniProt NCBI
SLC4A7	Sodium bicarbonate cotransporter 3 (Electroneutral Na/HCO(3) cotransporter) (Sodium bicarbonate cotransporter 2) (Sodium bicarbonate cotransporter 2b) (Bicarbonate transporter) (Solute carrier family 4 member 7)	5	UniProt NCBI
LGALS9C	Galectin-9C (Gal-9C) (Galectin-9-like protein B)	5	UniProt NCBI
SLC44A2	Choline transporter-like protein 2 (Solute carrier family 44 member 2)	5	UniProt NCBI
SLC12A6	Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3)	5	UniProt NCBI
SLC30A1	Proton-coupled zinc antiporter SLC30A1 (Solute carrier family 30 member 1) (Zinc transporter 1)	5	UniProt NCBI
CD63	CD63 antigen (Granulophysin) (Lysosomal-associated membrane protein 3) (LAMP-3) (Lysosome integral membrane protein 1) (Limp1) (Melanoma-associated antigen ME491) (OMA81H) (Ocular melanoma-associated antigen) (Tetraspanin-30) (Tspan-30) (CD antigen CD63)	5	UniProt NCBI
LGALS9B	Galectin-9B (Gal-9B) (Galectin-9-like protein A)	4	UniProt NCBI
CLCN3	H(+)/Cl(-) exchange transporter 3 (Chloride channel protein 3) (ClC-3) (Chloride transporter ClC-3)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-425407	3.39603276053e-09	0.583333333333	SLC17A5 SLC9A6 SLC12A6 SLC4A7 SLC30A1 SLC44A2 SLC12A4	SLC-mediated transmembrane transport
GO:0015291	2.81549204512e-07	0.583333333333	SLC17A5 SLC12A6 SLC4A7 SLC12A4 SLC9A6 CLCN3 SLC30A1	secondary active transmembrane transporter activity
REAC:R-HSA-425393	2.88620400082e-07	0.416666666667	SLC4A7 SLC17A5 SLC12A4 SLC12A6 SLC9A6	Transport of inorganic cations/anions and amino acids/oligopeptides
REAC:R-HSA-382551	3.51333038855e-07	0.666666666667	SLC17A5 SLC9A6 SLC12A6 SLC4A7 SLC30A1 SLC44A2 CLCN3 SLC12A4	Transport of small molecules
GO:0016936	2.11464090368e-05	0.25	LGALS9 LGALS9B LGALS9C	galactoside binding
GO:0022804	2.75698780463e-05	0.583333333333	SLC17A5 SLC12A6 SLC4A7 SLC12A4 SLC9A6 CLCN3 SLC30A1	active transmembrane transporter activity
GO:0022853	4.83308648442e-05	0.5	SLC17A5 SLC12A6 SLC4A7 SLC12A4 SLC9A6 SLC30A1	active monoatomic ion transmembrane transporter activity
GO:0015318	0.000455855308592	0.583333333333	SLC17A5 SLC12A6 SLC4A7 SLC12A4 SLC9A6 CLCN3 SLC30A1	inorganic molecular entity transmembrane transporter activity
GO:0022857	0.000507490457028	0.666666666667	SLC17A5 SLC9A6 SLC12A6 SLC4A7 SLC30A1 SLC44A2 CLCN3 SLC12A4	transmembrane transporter activity
GO:2000562	0.000738757615619	0.25	LGALS9 LGALS9B LGALS9C	negative regulation of CD4-positive, alpha-beta T cell proliferation
GO:0015075	0.00075484990408	0.583333333333	SLC17A5 SLC12A6 SLC4A7 SLC12A4 SLC9A6 CLCN3 SLC30A1	monoatomic ion transmembrane transporter activity
GO:0055085	0.00117405115425	0.666666666667	SLC44A2 SLC12A6 SLC4A7 SLC12A4 SLC9A6 CLCN3 CD63 SLC30A1	transmembrane transport
GO:0005215	0.00123516236715	0.666666666667	SLC17A5 SLC9A6 SLC12A6 SLC4A7 SLC30A1 SLC44A2 CLCN3 SLC12A4	transporter activity
GO:0046642	0.00177138039123	0.25	LGALS9 LGALS9B LGALS9C	negative regulation of alpha-beta T cell proliferation
REAC:R-HSA-426117	0.00251452957861	0.166666666667	SLC12A6 SLC12A4	Cation-coupled Chloride cotransporters
GO:0035739	0.00252937426606	0.25	LGALS9 LGALS9B LGALS9C	CD4-positive, alpha-beta T cell proliferation
GO:2000561	0.00252937426606	0.25	LGALS9 LGALS9B LGALS9C	regulation of CD4-positive, alpha-beta T cell proliferation
REAC:R-HSA-5619102	0.00609913510372	0.25	SLC17A5 SLC12A6 SLC9A6	SLC transporter disorders
GO:0022890	0.00622844916467	0.5	SLC17A5 SLC12A6 SLC4A7 SLC12A4 SLC9A6 SLC30A1	inorganic cation transmembrane transporter activity
GO:0055080	0.00633773184659	0.5	CLCN3 SLC4A7 SLC12A4 SLC9A6 SLC12A6 SLC30A1	monoatomic cation homeostasis
GO:0050801	0.00702723268173	0.5	CLCN3 SLC4A7 SLC12A4 SLC9A6 SLC12A6 SLC30A1	monoatomic ion homeostasis
GO:0006811	0.0079497698747	0.583333333333	SLC17A5 CD63 SLC12A4 SLC9A6 CLCN3 SLC12A6 SLC30A1	monoatomic ion transport
GO:0008324	0.0102710267848	0.5	SLC17A5 SLC12A6 SLC4A7 SLC12A4 SLC9A6 SLC30A1	monoatomic cation transmembrane transporter activity
GO:0015294	0.010313517986	0.333333333333	SLC17A5 SLC12A4 SLC12A6 SLC4A7	solute:monoatomic cation symporter activity
GO:0015293	0.0116015273781	0.333333333333	SLC17A5 SLC12A4 SLC12A6 SLC4A7	symporter activity
GO:0006820	0.0145333810473	0.333333333333	SLC17A5 CLCN3 SLC12A4 SLC12A6	monoatomic anion transport
GO:0098659	0.0161908288804	0.333333333333	SLC9A6 SLC30A1 SLC12A4 SLC12A6	inorganic cation import across plasma membrane
GO:0099587	0.0161908288804	0.333333333333	SLC9A6 SLC30A1 SLC12A4 SLC12A6	inorganic ion import across plasma membrane
GO:2000515	0.0203399151593	0.25	LGALS9 LGALS9B LGALS9C	negative regulation of CD4-positive, alpha-beta T cell activation
GO:0098660	0.029672383386	0.5	CLCN3 SLC12A6 SLC12A4 SLC9A6 CD63 SLC30A1	inorganic ion transmembrane transport
GO:0006884	0.0322807659825	0.25	SLC12A6 SLC12A4 CLCN3	cell volume homeostasis
GO:0046633	0.0371057242165	0.25	LGALS9 LGALS9B LGALS9C	alpha-beta T cell proliferation
GO:0046640	0.0371057242165	0.25	LGALS9 LGALS9B LGALS9C	regulation of alpha-beta T cell proliferation
GO:0032689	0.0423869429414	0.25	LGALS9 LGALS9B LGALS9C	negative regulation of type II interferon production
GO:0034220	0.0441280269557	0.5	CLCN3 SLC12A6 SLC12A4 SLC9A6 CD63 SLC30A1	monoatomic ion transmembrane transport
GO:0019725	0.0446764365865	0.5	CLCN3 SLC4A7 SLC12A4 SLC9A6 SLC12A6 SLC30A1	cellular homeostasis
GO:0046636	0.0481447187643	0.25	LGALS9 LGALS9B LGALS9C	negative regulation of alpha-beta T cell activation
REAC:R-HSA-5619115	0.0493051559831	0.25	SLC17A5 SLC12A6 SLC9A6	Disorders of transmembrane transporters

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
LGALS9	LGALS9B	1.0
LGALS9	LGALS9C	1.0		mutually_exclusive (Q7Z3C6)
SLC12A4	SLC12A6	0.999	0.306
LGALS9	SLC4A7	0.998	0.182
LGALS9	SLC12A6	0.997	0.096
LGALS9	CD63	0.996	0.294
SLC17A5	LGALS9	0.996	0.092
SLC30A1	LGALS9B	0.996
LGALS9	ATP2B4	0.996	0.29
LGALS9	CD58	0.994	0.104
SLC12A4	LGALS9	0.993	0.174
ATP2B4	LGALS9C	0.993
LGALS9	CLCN3	0.992	0.08
SLC44A2	LGALS9	0.99	0.18
SLC9A6	LGALS9	0.987
SLC30A1	LGALS9	0.985	0.246
ATP2B4	SLC12A6	0.985	0.076
LGALS9B	CLCN3	0.984
ATP2B4	CD63	0.984	0.072
SLC12A4	SLC4A7	0.983	0.074
ATP2B4	LGALS9B	0.983
SLC4A7	LGALS9B	0.978
CD58	SLC12A6	0.978	0.062
SLC30A1	SLC12A6	0.978	0.034
SLC12A6	LGALS9B	0.978
SLC12A4	CLCN3	0.977	0.128
CD58	CD63	0.976	0.064
SLC4A7	SLC12A6	0.972	0.028
SLC9A6	CD63	0.965
SLC12A6	CLCN3	0.959	0.104
CD58	SLC4A7	0.956	0.054
SLC12A4	CD58	0.955	0.05
SLC17A5	CD58	0.952	0.064
SLC12A6	CD63	0.95	0.042
SLC30A1	CLCN3	0.941	0.114
ATP2B4	CD58	0.938	0.138
SLC9A6	SLC12A4	0.938
SLC12A4	ATP2B4	0.928	0.124
ATP2B4	CLCN3	0.921	0.13
SLC12A4	CD63	0.918	0.066
SLC17A5	CD63	0.915	0.238
SLC17A5	SLC30A1	0.914	0.068
ATP2B4	SLC4A7	0.914	0.08
CD58	LGALS9C	0.91
SLC4A7	CD63	0.91	0.054
SLC4A7	LGALS9C	0.91
SLC12A4	LGALS9B	0.907
SLC9A6	SLC12A6	0.906
SLC30A1	SLC4A7	0.902	0.112
LGALS9C	CD63	0.901
SLC17A5	SLC12A6	0.897	0.078
SLC17A5	SLC12A4	0.896	0.116
SLC30A1	ATP2B4	0.889	0.06
CD63	LGALS9B	0.887
SLC17A5	SLC4A7	0.887	0.092
SLC4A7	CLCN3	0.879	0.048
SLC12A4	LGALS9C	0.878
SLC9A6	CD58	0.871
SLC17A5	CLCN3	0.859	0.134	mutually_exclusive (O00214)
SLC9A6	SLC4A7	0.857
SLC9A6	LGALS9B	0.847
CD58	LGALS9B	0.841
LGALS9C	SLC12A6	0.832
SLC17A5	ATP2B4	0.829	0.112
SLC30A1	CD58	0.829	0.072
SLC30A1	SLC12A4	0.807	0.046
SLC44A2	SLC12A6	0.806	0.078
SLC44A2	SLC12A4	0.752	0.082
SLC17A5	LGALS9B	0.73
SLC9A6	CLCN3	0.693
SLC44A2	SLC17A5	0.656	0.068
SLC44A2	CD58	0.633	0.058
SLC44A2	SLC4A7	0.587	0.068
SLC44A2	ATP2B4	0.587	0.106
SLC44A2	CD63	0.586	0.154
SLC17A5	SLC9A6	0.569
SLC9A6	ATP2B4	0.487
SLC30A1	SLC9A6	0.45
SLC44A2	LGALS9B	0.418
SLC44A2	SLC9A6	0.345
CD58	CLCN3	0.331	0.058
SLC30A1	CD63	0.313	0.026
CD63	CLCN3	0.307	0.186
SLC44A2	SLC30A1	0.249	0.026
SLC44A2	CLCN3	0.159	0.086

Related Complexes

Genename	Complexes
SLC17A5	huMAP3_00269.1 huMAP3_02201.1 huMAP3_04870.1 huMAP3_05584.1 huMAP3_08689.1 huMAP3_09336.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11349.1
SLC9A6	huMAP3_02201.1 huMAP3_03858.1 huMAP3_10848.1 huMAP3_11004.1 huMAP3_11349.1
SLC12A4	huMAP3_02201.1 huMAP3_02898.1 huMAP3_04870.1 huMAP3_05584.1 huMAP3_08689.1 huMAP3_09336.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11349.1
LGALS9	huMAP3_02201.1 huMAP3_04649.1 huMAP3_04870.1 huMAP3_06126.1 huMAP3_06308.1 huMAP3_06959.1 huMAP3_07990.1 huMAP3_08376.1 huMAP3_09336.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11349.1
ATP2B4	huMAP3_02201.1 huMAP3_04870.1 huMAP3_06126.1 huMAP3_08376.1 huMAP3_09336.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11349.1
CD58	huMAP3_02201.1 huMAP3_03234.1 huMAP3_04870.1 huMAP3_05584.1 huMAP3_06308.1 huMAP3_08689.1 huMAP3_09336.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11349.1 huMAP3_14961.1
SLC4A7	huMAP3_02201.1 huMAP3_06126.1 huMAP3_06308.1 huMAP3_08689.1 huMAP3_09336.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11349.1 huMAP3_12418.1
LGALS9C	huMAP3_02201.1 huMAP3_06126.1 huMAP3_07990.1 huMAP3_08376.1 huMAP3_09336.1 huMAP3_10848.1 huMAP3_11349.1
SLC44A2	huMAP3_00057.1 huMAP3_02201.1 huMAP3_08376.1 huMAP3_09336.1 huMAP3_10848.1 huMAP3_11349.1 huMAP3_12151.1
SLC12A6	huMAP3_02201.1 huMAP3_04870.1 huMAP3_05584.1 huMAP3_06308.1 huMAP3_08689.1 huMAP3_09336.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11349.1
SLC30A1	huMAP3_00638.1 huMAP3_02201.1 huMAP3_06126.1 huMAP3_08376.1 huMAP3_09336.1 huMAP3_09429.1 huMAP3_10848.1 huMAP3_11349.1
CD63	huMAP3_02201.1 huMAP3_04870.1 huMAP3_05584.1 huMAP3_08689.1 huMAP3_09336.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11349.1 huMAP3_13021.1
LGALS9B	huMAP3_02201.1 huMAP3_04609.1 huMAP3_04870.1 huMAP3_06126.1 huMAP3_09336.1 huMAP3_09405.1 huMAP3_10848.1 huMAP3_10980.1 huMAP3_11349.1
CLCN3	huMAP3_02201.1 huMAP3_02342.1 huMAP3_02700.1 huMAP3_06126.1 huMAP3_07074.1 huMAP3_08376.1 huMAP3_08506.1 huMAP3_09336.1 huMAP3_09950.1 huMAP3_10456.1 huMAP3_10638.1 huMAP3_10848.1 huMAP3_11349.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_02201.1

Complex Portal: CPX-12682