hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02221.1
Complex Portal: CPX-18270
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ZNF536 | Zinc finger protein 536 | 4 | UniProt NCBI |
| CTBP2 | C-terminal-binding protein 2 (CtBP2) | 5 | UniProt NCBI |
| LCORL | Ligand-dependent nuclear receptor corepressor-like protein (LCoR-like protein) | 4 | UniProt NCBI |
| ZNF516 | Zinc finger protein 516 | 5 | UniProt NCBI |
| ZEB2 | Zinc finger E-box-binding homeobox 2 (Smad-interacting protein 1) (SMADIP1) (Zinc finger homeobox protein 1b) | 5 | UniProt NCBI |
| CTBP1 | C-terminal-binding protein 1 (CtBP1) (EC 1.1.1.-) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:642 | 2.2822971401e-09 | 0.666666666667 | ZNF516 CTBP1 CTBP2 ZEB2 | CtBP complex |
| CORUM:2921 | 5.12534978153e-05 | 0.333333333333 | CTBP1 CTBP2 | SHARP-CtBP complex |
| REAC:R-HSA-5339700 | 7.74455426548e-05 | 0.333333333333 | CTBP1 CTBP2 | Signaling by TCF7L2 mutants |
| CORUM:643 | 0.000614368794823 | 0.333333333333 | CTBP1 CTBP2 | CtBP core complex |
| REAC:R-HSA-4641265 | 0.0014177632075 | 0.333333333333 | CTBP1 CTBP2 | Repression of WNT target genes |
| WP:WP268 | 0.00630862924989 | 0.333333333333 | CTBP1 CTBP2 | Notch signaling |
| KEGG:04330 | 0.00813218066336 | 0.333333333333 | CTBP1 CTBP2 | Notch signaling pathway |
| REAC:R-HSA-4791275 | 0.0135559590666 | 0.333333333333 | CTBP1 CTBP2 | Signaling by WNT in cancer |
| KEGG:05220 | 0.0193802025824 | 0.333333333333 | CTBP1 CTBP2 | Chronic myeloid leukemia |
| HP:0009918 | 0.020461457105 | 0.333333333333 | ZEB2 CTBP1 | Ectopia pupillae |
| WP:WP4336 | 0.0268597929621 | 0.333333333333 | CTBP1 CTBP2 | ncRNAs involved in Wnt signaling in hepatocellular carcinoma |
| WP:WP4258 | 0.0337850948883 | 0.333333333333 | CTBP1 CTBP2 | lncRNA in canonical Wnt signaling and colorectal cancer |
| WP:WP399 | 0.0433081873621 | 0.333333333333 | CTBP1 CTBP2 | Wnt signaling pathway and pluripotency |
| WP:WP428 | 0.049971715525 | 0.333333333333 | CTBP1 CTBP2 | Wnt signaling |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CTBP1 | CTBP2 | 0.999 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () Malo fraction boldt_WMM | ||
| ZNF516 | CTBP1 | 0.998 | 0.188 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | |
| LCORL | CTBP1 | 0.984 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ZNF516 | CTBP2 | 0.977 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| ZNF536 | CTBP1 | 0.973 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | ||
| ZEB2 | CTBP1 | 0.956 | 0.108 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | |
| ZNF536 | LCORL | 0.612 | 0.03 | bioplex_WMM bioplex3_WMM WMM_only | |
| LCORL | ZNF516 | 0.594 | 0.134 | bioplex_WMM bioplex3_WMM WMM_only | |
| ZNF536 | ZEB2 | 0.587 | 0.116 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| LCORL | ZEB2 | 0.568 | 0.068 | bioplex_WMM bioplex3_WMM WMM_only | |
| ZNF516 | ZEB2 | 0.417 | 0.174 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| LCORL | CTBP2 | 0.386 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ZNF536 | ZNF516 | 0.303 | 0.048 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| ZEB2 | CTBP2 | 0.3 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| ZNF536 | CTBP2 | 0.263 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes