hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02226.1
Complex Portal: CPX-13915
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DYNC1I2 | Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2) | 5 | UniProt NCBI |
| DYNC1I1 | Cytoplasmic dynein 1 intermediate chain 1 (Cytoplasmic dynein intermediate chain 1) (Dynein intermediate chain 1, cytosolic) (DH IC-1) | 5 | UniProt NCBI |
| PCBP4 | Poly(rC)-binding protein 4 (Alpha-CP4) | 4 | UniProt NCBI |
| DYNC1LI2 | Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic) (LIC-2) (LIC53/55) | 5 | UniProt NCBI |
| DYNC1H1 | Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) | 5 | UniProt NCBI |
| DYNC1LI1 | Cytoplasmic dynein 1 light intermediate chain 1 (LIC1) (Dynein light chain A) (DLC-A) (Dynein light intermediate chain 1, cytosolic) (DLIC-1) | 5 | UniProt NCBI |
| DYNLT3 | Dynein light chain Tctex-type 3 (Protein 91/23) (T-complex-associated testis-expressed 1-like) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4532 | 1.38638958491e-14 | 0.857142857143 | DYNC1LI1 DYNC1H1 DYNC1I2 DYNC1I1 DYNC1LI2 DYNLT3 | Intraflagellar transport proteins binding to dynein |
| GO:0005868 | 1.40340440006e-12 | 0.857142857143 | DYNC1LI1 DYNC1H1 DYNC1I2 DYNC1I1 DYNC1LI2 DYNLT3 | cytoplasmic dynein complex |
| GO:0030286 | 2.862432668e-11 | 0.857142857143 | DYNC1LI1 DYNC1H1 DYNC1I2 DYNC1I1 DYNC1LI2 DYNLT3 | dynein complex |
| KEGG:04962 | 1.29361057413e-10 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | Vasopressin-regulated water reabsorption |
| WP:WP5085 | 2.24507052539e-10 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | Vasopressin regulated water reabsorption |
| REAC:R-HSA-9646399 | 5.469921249e-10 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | Aggrephagy |
| KEGG:04814 | 6.12035763775e-10 | 0.857142857143 | DYNC1LI1 DYNC1H1 DYNC1I2 DYNC1I1 DYNC1LI2 DYNLT3 | Motor proteins |
| REAC:R-HSA-6811436 | 1.54491078832e-09 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | COPI-independent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-3371497 | 1.8946190242e-09 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand |
| KEGG:05132 | 4.37451225231e-09 | 0.857142857143 | DYNC1LI1 DYNC1H1 DYNC1I2 DYNC1I1 DYNC1LI2 DYNLT3 | Salmonella infection |
| REAC:R-HSA-9663891 | 1.25488668534e-08 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | Selective autophagy |
| CORUM:6038 | 2.80877722849e-08 | 0.428571428571 | DYNC1H1 DYNC1I1 DYNC1LI1 | Dynein complex |
| REAC:R-HSA-141444 | 3.5685870487e-08 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-141424 | 3.5685870487e-08 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | Amplification of signal from the kinetochores |
| REAC:R-HSA-6807878 | 4.43349471247e-08 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | COPI-mediated anterograde transport |
| KEGG:04145 | 6.0172872499e-08 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | Phagosome |
| REAC:R-HSA-69620 | 6.12646112987e-08 | 0.857142857143 | DYNC1LI1 DYNC1H1 PCBP4 DYNC1I2 DYNC1LI2 DYNC1I1 | Cell Cycle Checkpoints |
| CORUM:6039 | 7.02050133195e-08 | 0.428571428571 | DYNC1H1 DYNC1I1 DYNC1LI1 | Dynein-dynactin complex |
| REAC:R-HSA-69618 | 8.07404224533e-08 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | Mitotic Spindle Checkpoint |
| REAC:R-HSA-9648025 | 1.01611866673e-07 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | EML4 and NUDC in mitotic spindle formation |
| GO:0005875 | 1.09242060629e-07 | 0.857142857143 | DYNC1LI1 DYNC1H1 DYNC1I2 DYNC1I1 DYNC1LI2 DYNLT3 | microtubule associated complex |
| REAC:R-HSA-2132295 | 1.21235942946e-07 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | MHC class II antigen presentation |
| REAC:R-HSA-9609690 | 1.37851310836e-07 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | HCMV Early Events |
| REAC:R-HSA-2500257 | 1.43776669e-07 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-8856688 | 1.7653255087e-07 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | Golgi-to-ER retrograde transport |
| REAC:R-HSA-1632852 | 1.7653255087e-07 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | Macroautophagy |
| REAC:R-HSA-5663220 | 2.23432604085e-07 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | RHO GTPases Activate Formins |
| REAC:R-HSA-9612973 | 3.11939748367e-07 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | Autophagy |
| REAC:R-HSA-9609646 | 3.23287246817e-07 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | HCMV Infection |
| REAC:R-HSA-199977 | 3.34962044721e-07 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | ER to Golgi Anterograde Transport |
| GO:0045504 | 4.5526752727e-07 | 0.571428571429 | DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | dynein heavy chain binding |
| REAC:R-HSA-948021 | 8.50608466645e-07 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | Transport to the Golgi and subsequent modification |
| REAC:R-HSA-2467813 | 1.19467927608e-06 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | Separation of Sister Chromatids |
| REAC:R-HSA-6811442 | 1.51920639537e-06 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| REAC:R-HSA-68877 | 1.60006482778e-06 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | Mitotic Prometaphase |
| REAC:R-HSA-68882 | 3.13995293302e-06 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 3.21127050354e-06 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | Mitotic Metaphase and Anaphase |
| REAC:R-HSA-1640170 | 9.61127904246e-06 | 0.857142857143 | DYNC1LI1 DYNC1H1 PCBP4 DYNC1I2 DYNC1LI2 DYNC1I1 | Cell Cycle |
| REAC:R-HSA-446203 | 1.03632566951e-05 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | Asparagine N-linked glycosylation |
| REAC:R-HSA-195258 | 1.29732652309e-05 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | RHO GTPase Effectors |
| GO:0007018 | 1.32595390184e-05 | 0.857142857143 | DYNC1LI1 DYNC1H1 DYNC1I2 DYNC1I1 DYNC1LI2 DYNLT3 | microtubule-based movement |
| REAC:R-HSA-68886 | 4.94347788106e-05 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | M Phase |
| WP:WP4352 | 0.000124574325421 | 0.571428571429 | DYNC1H1 DYNLT3 DYNC1I2 DYNC1LI1 | Ciliary landscape |
| REAC:R-HSA-69278 | 0.000227158418852 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | Cell Cycle, Mitotic |
| REAC:R-HSA-199991 | 0.000347098893962 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.000454173249089 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | Vesicle-mediated transport |
| REAC:R-HSA-194315 | 0.000554819347598 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | Signaling by Rho GTPases |
| REAC:R-HSA-9716542 | 0.000618457686161 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
| REAC:R-HSA-1280218 | 0.000719278871417 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | Adaptive Immune System |
| REAC:R-HSA-9824446 | 0.000953213883488 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | Viral Infection Pathways |
| REAC:R-HSA-2262752 | 0.00109457503326 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | Cellular responses to stress |
| REAC:R-HSA-8953897 | 0.0011477966594 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | Cellular responses to stimuli |
| REAC:R-HSA-5663205 | 0.00262907091591 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | Infectious disease |
| GO:0007017 | 0.00377199817885 | 0.857142857143 | DYNC1LI1 DYNC1H1 DYNC1I2 DYNC1I1 DYNC1LI2 DYNLT3 | microtubule-based process |
| REAC:R-HSA-597592 | 0.0148745508598 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | Post-translational protein modification |
| GO:0015630 | 0.0362273678325 | 0.857142857143 | DYNC1LI1 DYNC1H1 DYNC1I2 DYNC1I1 DYNC1LI2 DYNLT3 | microtubule cytoskeleton |
| REAC:R-HSA-1643685 | 0.0367346572641 | 0.714285714286 | DYNC1H1 DYNC1LI1 DYNC1I2 DYNC1LI2 DYNC1I1 | Disease |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DYNC1I2 | DYNC1LI2 | 1.0 | 0.586 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| DYNC1I2 | DYNC1LI1 | 1.0 | 0.63 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| DYNC1I2 | DYNC1I1 | 0.999 | 0.214 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| DYNC1LI2 | DYNC1LI1 | 0.999 | 0.296 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM | |
| DYNC1LI2 | DYNC1H1 | 0.999 | 0.488 | hein_WMM bioplex_WMM bioplex3_WMM boldt hein () Malo gupta_WMM fraction boldt_WMM | |
| DYNC1H1 | DYNC1LI1 | 0.999 | 0.618 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| DYNC1I1 | DYNC1LI2 | 0.999 | 0.18 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| DYNC1I1 | DYNC1LI1 | 0.999 | 0.198 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| DYNC1I2 | DYNC1H1 | 0.999 | 0.922 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM | |
| DYNC1I1 | DYNLT3 | 0.999 | 0.144 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DYNC1LI1 | DYNLT3 | 0.998 | 0.084 | hein_WMM bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only | |
| DYNC1I1 | DYNC1H1 | 0.998 | 0.22 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| DYNC1I2 | DYNLT3 | 0.997 | 0.434 | hein_WMM bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only | |
| DYNC1LI2 | DYNLT3 | 0.983 | 0.032 | hein_WMM bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| PCBP4 | DYNC1LI1 | 0.978 | 0.172 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DYNC1H1 | DYNLT3 | 0.972 | 0.336 | hein_WMM bioplex_WMM bioplex3_WMM boldt hein () boldt_WMM | |
| PCBP4 | DYNC1I2 | 0.969 | 0.05 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PCBP4 | DYNC1H1 | 0.918 | 0.19 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PCBP4 | DYNC1LI2 | 0.876 | 0.09 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
Related Complexes