hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02229.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DCAF8L2 | DDB1- and CUL4-associated factor 8-like protein 2 (WD repeat-containing protein 42C) | 2 | UniProt NCBI |
| CRBN | Protein cereblon | 5 | UniProt NCBI |
| CUL4A | Cullin-4A (CUL-4A) | 5 | UniProt NCBI |
| CUL4B | Cullin-4B (CUL-4B) | 5 | UniProt NCBI |
| DDB1 | DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe) | 5 | UniProt NCBI |
| BRWD3 | Bromodomain and WD repeat-containing protein 3 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6875 | 1.87066161015e-08 | 0.5 | DDB1 CRBN CUL4A | CRBN-DDB1-CUL4A-RBX1 E3 ubiquitin ligase |
| GO:0080008 | 2.03314862263e-08 | 0.833333333333 | DCAF8L2 DDB1 CRBN CUL4B CUL4A | Cul4-RING E3 ubiquitin ligase complex |
| CORUM:1162 | 4.675933868e-08 | 0.5 | CUL4B CUL4A DDB1 | Ubiquitin E3 ligase (DDB1, DDB2, CUL4A, CUL4B, RBX1) |
| GO:0031464 | 3.94651622678e-07 | 0.666666666667 | CUL4B DDB1 CRBN CUL4A | Cul4A-RING E3 ubiquitin ligase complex |
| REAC:R-HSA-110314 | 2.85755298292e-05 | 0.5 | CUL4B CUL4A DDB1 | Recognition of DNA damage by PCNA-containing replication complex |
| WP:WP4753 | 3.3828600382e-05 | 0.5 | CUL4B CUL4A DDB1 | Nucleotide excision repair |
| CORUM:391 | 5.12534978153e-05 | 0.333333333333 | CUL4A DDB1 | Ubiquitin E3 ligase (DDB1, CUL4A, RBX1) |
| CORUM:6494 | 5.12534978153e-05 | 0.333333333333 | CUL4A DDB1 | CUL4A-DDB1-WDR61 complex |
| CORUM:6493 | 5.12534978153e-05 | 0.333333333333 | CUL4A DDB1 | CUL4A-DDB1-WDR57 complex |
| CORUM:6492 | 5.12534978153e-05 | 0.333333333333 | CUL4A DDB1 | CUL4A-DDB1-WDR5B complex |
| CORUM:6486 | 5.12534978153e-05 | 0.333333333333 | CUL4A DDB1 | CUL4A-DDB1-DTL complex |
| CORUM:6490 | 5.12534978153e-05 | 0.333333333333 | CUL4B DDB1 | CUL4B-DDB1-WDR26 complex |
| CORUM:6487 | 5.12534978153e-05 | 0.333333333333 | CUL4B DDB1 | CUL4B-DDB1-TLE2 complex |
| CORUM:6488 | 5.12534978153e-05 | 0.333333333333 | CUL4A DDB1 | CUL4A-DDB1-EED complex |
| CORUM:6489 | 5.12534978153e-05 | 0.333333333333 | CUL4A DDB1 | CUL4A-DDB1-WDR5 complex |
| CORUM:2722 | 5.12534978153e-05 | 0.333333333333 | CUL4A DDB1 | Ubiquitin E3 ligase (DDB1, CUL4A, RBX1) |
| CORUM:6495 | 5.12534978153e-05 | 0.333333333333 | CUL4B DDB1 | CUL4B-DDB1-GRWD1 complex |
| CORUM:6491 | 5.12534978153e-05 | 0.333333333333 | CUL4A DDB1 | CUL4A-DDB1-RBBP5 complex |
| CORUM:6550 | 5.12534978153e-05 | 0.333333333333 | CUL4A DDB1 | CUL4B-DDB1-TLE1 complex |
| CORUM:6553 | 5.12534978153e-05 | 0.333333333333 | CUL4B DDB1 | CUL4B-DDB1-TLE3 complex |
| GO:0031461 | 5.79224844498e-05 | 0.833333333333 | DCAF8L2 DDB1 CRBN CUL4B CUL4A | cullin-RING ubiquitin ligase complex |
| REAC:R-HSA-5696394 | 5.93019629716e-05 | 0.5 | CUL4B CUL4A DDB1 | DNA Damage Recognition in GG-NER |
| KEGG:03420 | 6.08868725508e-05 | 0.5 | CUL4B CUL4A DDB1 | Nucleotide excision repair |
| REAC:R-HSA-5696400 | 7.49011945156e-05 | 0.5 | CUL4B CUL4A DDB1 | Dual Incision in GG-NER |
| REAC:R-HSA-5696395 | 8.06503831344e-05 | 0.5 | CUL4B CUL4A DDB1 | Formation of Incision Complex in GG-NER |
| CORUM:2172 | 0.000102488289015 | 0.333333333333 | CUL4A DDB1 | Ubiquitin E3 ligase (CDT1, DDB1, CUL4A, RBX1) |
| CORUM:6291 | 0.000102488289015 | 0.333333333333 | CUL4A DDB1 | Ubiquitin E3 ligase (DDIT4, DDB1, BTRC, CUL4A) |
| REAC:R-HSA-73893 | 0.000113827315454 | 0.5 | CUL4B CUL4A DDB1 | DNA Damage Bypass |
| REAC:R-HSA-6781823 | 0.000155019643237 | 0.5 | CUL4B CUL4A DDB1 | Formation of TC-NER Pre-Incision Complex |
| WP:WP5114 | 0.000169701188809 | 0.5 | CUL4B CUL4A DDB1 | Nucleotide excision repair in xeroderma pigmentosum |
| CORUM:6482 | 0.000170782642132 | 0.333333333333 | CUL4B DDB1 | CUL4B-DDB1-DTL-CSN complex |
| CORUM:1214 | 0.000170782642132 | 0.333333333333 | CUL4A DDB1 | Ubiquitin E3 ligase (DET1, DDB1, CUL4A, RBX1, COP1) |
| CORUM:1211 | 0.00025612721106 | 0.333333333333 | CUL4B DDB1 | Ubiquitin E3 ligase (AHR, ARNT, DDB1, TBL3, CUL4B, RBX1) |
| REAC:R-HSA-6782210 | 0.00027807877525 | 0.5 | CUL4B CUL4A DDB1 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| REAC:R-HSA-6782135 | 0.000291709735154 | 0.5 | CUL4B CUL4A DDB1 | Dual incision in TC-NER |
| REAC:R-HSA-6781827 | 0.000511131050826 | 0.5 | CUL4B CUL4A DDB1 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| WP:WP4946 | 0.000634899192361 | 0.5 | CUL4B CUL4A DDB1 | DNA repair pathways full network |
| REAC:R-HSA-5696399 | 0.000641417793729 | 0.5 | CUL4B CUL4A DDB1 | Global Genome Nucleotide Excision Repair (GG-NER) |
| GO:0000151 | 0.000709782706696 | 0.833333333333 | DCAF8L2 DDB1 CRBN CUL4B CUL4A | ubiquitin ligase complex |
| KEGG:04120 | 0.000781901287408 | 0.5 | CUL4B CUL4A DDB1 | Ubiquitin mediated proteolysis |
| CORUM:727 | 0.00112572613738 | 0.333333333333 | CUL4A DDB1 | CSA complex |
| CORUM:726 | 0.00112572613738 | 0.333333333333 | CUL4A DDB1 | DDB2 complex |
| CORUM:728 | 0.00112572613738 | 0.333333333333 | CUL4A DDB1 | CSA-POLIIa complex |
| REAC:R-HSA-5696398 | 0.00141970658079 | 0.5 | CUL4B CUL4A DDB1 | Nucleotide Excision Repair |
| KEGG:05170 | 0.00227953772694 | 0.5 | CUL4B CUL4A DDB1 | Human immunodeficiency virus 1 infection |
| CORUM:929 | 0.00953030807474 | 0.333333333333 | CUL4A DDB1 | CEN complex |
| REAC:R-HSA-8951664 | 0.012792006299 | 0.5 | CUL4B CUL4A DDB1 | Neddylation |
| REAC:R-HSA-73894 | 0.0318872588213 | 0.5 | CUL4B CUL4A DDB1 | DNA Repair |
| WP:WP4541 | 0.0451642815361 | 0.333333333333 | CUL4A DDB1 | Hippo Merlin signaling dysregulation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CUL4A | CUL4B | 0.999 | 0.374 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only |
| CUL4B | DDB1 | 0.998 | 0.272 | hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| CRBN | CUL4B | 0.997 | 0.136 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CUL4A | BRWD3 | 0.996 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| CUL4A | DDB1 | 0.995 | 0.628 | hein_WMM bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () gupta_WMM fraction boldt_WMM |
| DDB1 | BRWD3 | 0.991 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| CRBN | CUL4A | 0.985 | 0.228 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CRBN | DDB1 | 0.983 | 0.307 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CUL4B | BRWD3 | 0.955 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
Related Complexes