hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02236.1
Complex Portal: CPX-24838
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| APOA2 | Apolipoprotein A-II (Apo-AII) (ApoA-II) (Apolipoprotein A2) [Cleaved into: Proapolipoprotein A-II (ProapoA-II); Truncated apolipoprotein A-II (Apolipoprotein A-II(1-76))] | 5 | UniProt NCBI |
| ORM2 | Alpha-1-acid glycoprotein 2 (AGP 2) (Orosomucoid-2) (OMD 2) | 5 | UniProt NCBI |
| CP | Ceruloplasmin (Cuproxidase ceruloplasmin) (EC 1.16.3.4) (Ferroxidase ceruloplasmin) (EC 1.16.3.1) | 5 | UniProt NCBI |
| A1BG | Alpha-1B-glycoprotein (Alpha-1-B glycoprotein) | 5 | UniProt NCBI |
| HPX | Hemopexin (Beta-1B-glycoprotein) | 5 | UniProt NCBI |
| KNG1 | Kininogen-1 (Alpha-2-thiol proteinase inhibitor) (Fitzgerald factor) (High molecular weight kininogen) (HMWK) (Williams-Fitzgerald-Flaujeac factor) [Cleaved into: Kininogen-1 heavy chain; T-kinin (Ile-Ser-Bradykinin); Bradykinin (Kallidin I); Lysyl-bradykinin (Kallidin II); Kininogen-1 light chain; Low molecular weight growth-promoting factor] | 5 | UniProt NCBI |
| ITIH2 | Inter-alpha-trypsin inhibitor heavy chain H2 (ITI heavy chain H2) (ITI-HC2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0072562 | 4.40809271077e-09 | 1.0 | A1BG ITIH2 KNG1 CP APOA2 HPX | blood microparticle |
| REAC:R-HSA-8957275 | 3.20062837424e-06 | 0.666666666667 | KNG1 ITIH2 APOA2 CP | Post-translational protein phosphorylation |
| REAC:R-HSA-381426 | 5.63029500246e-06 | 0.666666666667 | KNG1 ITIH2 APOA2 CP | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CP | KNG1 | 0.985 | bioplex_WMM bioplex3_WMM WMM_only | ||
| APOA2 | CP | 0.985 | 0.554 | bioplex_WMM bioplex3_WMM WMM_only | |
| APOA2 | HPX | 0.985 | 0.468 | bioplex_WMM bioplex3_WMM WMM_only | |
| ORM2 | CP | 0.984 | 0.648 |
structurally_consistent (O15547)
|
bioplex_WMM bioplex3_WMM WMM_only |
| ORM2 | HPX | 0.983 | 0.531 | bioplex_WMM bioplex3_WMM WMM_only | |
| CP | HPX | 0.983 | 0.36 | bioplex_WMM bioplex3_WMM WMM_only | |
| HPX | KNG1 | 0.982 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CP | A1BG | 0.981 | 0.532 | bioplex_WMM bioplex3_WMM WMM_only | |
| A1BG | HPX | 0.978 | 0.606 | bioplex_WMM bioplex3_WMM WMM_only | |
| CP | ITIH2 | 0.975 | 0.13 | bioplex_WMM bioplex3_WMM WMM_only | |
| HPX | ITIH2 | 0.974 | 0.246 | bioplex_WMM bioplex3_WMM WMM_only | |
| ORM2 | ITIH2 | 0.973 | 0.308 |
structurally_consistent (O15547)
|
bioplex_WMM bioplex3_WMM WMM_only |
| ORM2 | KNG1 | 0.972 | bioplex_WMM bioplex3_WMM WMM_only | ||
| APOA2 | A1BG | 0.972 | 0.41 | bioplex_WMM bioplex3_WMM WMM_only | |
| APOA2 | ORM2 | 0.969 | 0.682 | bioplex_WMM bioplex3_WMM WMM_only | |
| ORM2 | A1BG | 0.969 | 0.674 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM WMM_only |
| APOA2 | KNG1 | 0.966 | bioplex_WMM bioplex3_WMM WMM_only | ||
| A1BG | KNG1 | 0.964 | bioplex_WMM bioplex3_WMM WMM_only | ||
| APOA2 | ITIH2 | 0.953 | 0.342 | bioplex_WMM bioplex3_WMM WMM_only | |
| KNG1 | ITIH2 | 0.951 | bioplex_WMM bioplex3_WMM WMM_only | ||
| A1BG | ITIH2 | 0.948 | 0.376 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes