hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02239.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ATP6V0A2 | V-type proton ATPase 116 kDa subunit a 2 (V-ATPase 116 kDa subunit a 2) (Lysosomal H(+)-transporting ATPase V0 subunit a 2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2) | 5 | UniProt NCBI |
| ATP6V0D1 | V-type proton ATPase subunit d 1 (V-ATPase subunit d 1) (32 kDa accessory protein) (V-ATPase 40 kDa accessory protein) (V-ATPase AC39 subunit) (p39) (Vacuolar proton pump subunit d 1) | 5 | UniProt NCBI |
| TCIRG1 | V-type proton ATPase 116 kDa subunit a 3 (V-ATPase 116 kDa subunit a 3) (Osteoclastic proton pump 116 kDa subunit) (OC-116 kDa) (OC116) (T-cell immune regulator 1) (T-cell immune response cDNA7 protein) (TIRC7) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04966 | 9.25155395361e-08 | 1.0 | ATP6V0A2 ATP6V0D1 TCIRG1 | Collecting duct acid secretion |
| KEGG:05110 | 7.41273577649e-07 | 1.0 | ATP6V0A2 ATP6V0D1 TCIRG1 | Vibrio cholerae infection |
| REAC:R-HSA-917977 | 1.5285886144e-06 | 1.0 | ATP6V0A2 ATP6V0D1 TCIRG1 | Transferrin endocytosis and recycling |
| REAC:R-HSA-77387 | 1.5285886144e-06 | 1.0 | ATP6V0A2 ATP6V0D1 TCIRG1 | Insulin receptor recycling |
| KEGG:04721 | 1.78762380741e-06 | 1.0 | ATP6V0A2 ATP6V0D1 TCIRG1 | Synaptic vesicle cycle |
| KEGG:05120 | 2.07446899521e-06 | 1.0 | ATP6V0A2 ATP6V0D1 TCIRG1 | Epithelial cell signaling in Helicobacter pylori infection |
| REAC:R-HSA-1222556 | 2.09737662446e-06 | 1.0 | ATP6V0A2 ATP6V0D1 TCIRG1 | ROS and RNS production in phagocytes |
| KEGG:05323 | 2.61801737967e-06 | 1.0 | ATP6V0A2 ATP6V0D1 TCIRG1 | Rheumatoid arthritis |
| REAC:R-HSA-917937 | 1.03119073194e-05 | 1.0 | ATP6V0A2 ATP6V0D1 TCIRG1 | Iron uptake and transport |
| KEGG:00190 | 1.54230874605e-05 | 1.0 | ATP6V0A2 ATP6V0D1 TCIRG1 | Oxidative phosphorylation |
| KEGG:04142 | 1.58086646471e-05 | 1.0 | ATP6V0A2 ATP6V0D1 TCIRG1 | Lysosome |
| REAC:R-HSA-74752 | 1.76468929782e-05 | 1.0 | ATP6V0A2 ATP6V0D1 TCIRG1 | Signaling by Insulin receptor |
| KEGG:04145 | 1.95719209727e-05 | 1.0 | ATP6V0A2 ATP6V0D1 TCIRG1 | Phagosome |
| KEGG:05152 | 2.65416687338e-05 | 1.0 | ATP6V0A2 ATP6V0D1 TCIRG1 | Tuberculosis |
| REAC:R-HSA-983712 | 0.000144704522421 | 1.0 | ATP6V0A2 ATP6V0D1 TCIRG1 | Ion channel transport |
| GO:0016471 | 0.000148024863258 | 1.0 | ATP6V0A2 ATP6V0D1 TCIRG1 | vacuolar proton-transporting V-type ATPase complex |
| GO:0033176 | 0.000170228592746 | 1.0 | ATP6V0A2 ATP6V0D1 TCIRG1 | proton-transporting V-type ATPase complex |
| KEGG:05165 | 0.000218999274719 | 1.0 | ATP6V0A2 ATP6V0D1 TCIRG1 | Human papillomavirus infection |
| GO:0007035 | 0.000314889254566 | 1.0 | ATP6V0A2 ATP6V0D1 TCIRG1 | vacuolar acidification |
| GO:0051452 | 0.00102463963787 | 1.0 | ATP6V0A2 ATP6V0D1 TCIRG1 | intracellular pH reduction |
| GO:0030670 | 0.00110345807156 | 1.0 | ATP6V0A2 ATP6V0D1 TCIRG1 | phagocytic vesicle membrane |
| GO:0016469 | 0.00127301382402 | 1.0 | ATP6V0A2 ATP6V0D1 TCIRG1 | proton-transporting two-sector ATPase complex |
| GO:1902600 | 0.00252170927764 | 1.0 | ATP6V0A2 ATP6V0D1 TCIRG1 | proton transmembrane transport |
| GO:0051453 | 0.00328922780564 | 1.0 | ATP6V0A2 ATP6V0D1 TCIRG1 | regulation of intracellular pH |
| GO:0030641 | 0.00363525995351 | 1.0 | ATP6V0A2 ATP6V0D1 TCIRG1 | regulation of cellular pH |
| GO:0006885 | 0.00419852339422 | 1.0 | ATP6V0A2 ATP6V0D1 TCIRG1 | regulation of pH |
| REAC:R-HSA-9006934 | 0.00622622698696 | 1.0 | ATP6V0A2 ATP6V0D1 TCIRG1 | Signaling by Receptor Tyrosine Kinases |
| REAC:R-HSA-9639288 | 0.00937397262456 | 0.666666666667 | TCIRG1 ATP6V0D1 | Amino acids regulate mTORC1 |
| GO:0045335 | 0.00949377645712 | 1.0 | ATP6V0A2 ATP6V0D1 TCIRG1 | phagocytic vesicle |
| REAC:R-HSA-382551 | 0.0117092435511 | 1.0 | ATP6V0A2 ATP6V0D1 TCIRG1 | Transport of small molecules |
| HP:0005425 | 0.0142438401108 | 0.666666666667 | ATP6V0A2 TCIRG1 | Recurrent sinopulmonary infections |
| HP:0002812 | 0.0167410266547 | 0.666666666667 | ATP6V0A2 TCIRG1 | Coxa vara |
| KEGG:01100 | 0.0189521995452 | 1.0 | ATP6V0A2 ATP6V0D1 TCIRG1 | Metabolic pathways |
| GO:1904949 | 0.042099520671 | 1.0 | ATP6V0A2 ATP6V0D1 TCIRG1 | ATPase complex |
| GO:0030666 | 0.0488366704701 | 1.0 | ATP6V0A2 ATP6V0D1 TCIRG1 | endocytic vesicle membrane |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ATP6V0A2 | ATP6V0D1 | 0.999 | 0.138 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TCIRG1 | ATP6V0D1 | 0.999 | 0.254 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TCIRG1 | ATP6V0A2 | 0.992 | 0.062 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes